Search results for "topsentin"
showing 10 items of 41 documents
Antitumor activity of 2,5-bis-(3’-indolyl)-pyrroles, deaza-analogues of Nortopsentins
2012
A computational study to explore the molecular mechanisms behind the antiproliferative activity of Nortopsentin derivatives
2018
Nortopsentin analogues with potent activity against diffuse malignant peritoneal mesothelioma (DMPM)
2015
Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to targe…
2022
The enzyme glutaminase-1 (GLS-1) has shown a clear and coherent implication in the progression and exacerbation of different aggressive tumors such as glioblastoma, hepatocarcinoma, pancreas, bone, and triple-negative breast cancer. Few chemotypes are currently available as selective GLS-1 inhibitors, and still, fewer of them are at the clinical stage. In the present paper, starting from a naturally-inspired antitumor compound library, metabolomics has been used to putatively identify the molecular mechanism underlying biological activity. GLS-1 was identified as a potential target. Biochemical analysis confirmed the hypothesis leading to the identification of a new hit compound acting as a…
Synthesis and biological evaluation of new 1,2,4-oxadiazole derivatives of Topsentin
ANALOGHI DELL'ALCALOIDE MARINO NORTOPSENTINA: SINTESI ED ATTIVITA' ANTITUMORALE
2009
Synthesis of new derivatives of Nortopsentin with potential inhibitory activity against GSK-3b
New 1,2,4-oxadiazole nortopsentin derivatives with cytotoxic activity
2019
New analogs of nortopsentin, a natural 2,4-bis(3&prime
Biological evaluation of new 1,2,4-oxadiazole topsentin analogs as anticancer agents
2019
Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor activity
2019
Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor activity