Search results for "traite"
showing 10 items of 147 documents
Functional characterisation of the first HSP110 inhibitors.
2023
Heat shock proteins are molecular chaperones highly expressed in haematological malignancies. My laboratory has shown that the heat shock protein HSP110 is a new and important therapeutic target In colorectal cancer and in non-Hodgkin's lymphoma. As there were no existing inhibitors of HSP110, a screening strategy of a chemical library was carried out and allowed the identification of two molecules capable of specifically inhibiting the chaperone activity of HSP110. My thesis objective was to characterise and functionally validate these newly identified molecules in diffuse large cell B lymphomas. I have shown that one of these molecules limits the interaction of HSP110 with the SYK signall…
Travailler plus longtemps ? Enjeux professionnels et non-professionnels des départs à la retraite dans l'enseignement
2016
Au Québec, en raison du vieillissement de la population et de l’introduction, par le gouvernement, de politiques de maintien en emploi, les enseignants sont incités à travailler plus longtemps. Dans cet article, nous nous demandons si les enseignants peuvent être sensibles à ces incitations, et cherchons à en comprendre les raisons en analysant les conditions d’enseignement et les trajectoires de vie. La recherche s’appuie sur 24 entretiens semi-dirigés auprès d’enseignants âgés de 50 ans et plus, exerçant à différents niveaux dans les commissions scolaires francophones. Nous montrons que les enseignants rencontrés n’envisagent pas, pour la plupart, de prolonger leur service dans l’enseigne…
A measurement-based channel model for vehicular communications in tunnels
2014
Wireless Communications and Networking Conference (WCNC), 2014 IEEE, Istanbul, TURQUIE, 06-/04/2014 - 09/04/2014; In this paper, we present a new version of the iterative nonlinear least square approximation (INLSA) algorithm for the design of measurement-based channel simulators. The proposed method aims to match the time-variant impulse response (TVIR) of the simulation model to that of the measured channel. The propagation delays are discerned directly from the measurements, whereas the gains, the Doppler frequencies, and the phases are computed iteratively by minimizing a matching error norm. We evaluate the performance of the proposed method in terms of the approximation of the transfe…
Water and temperature contribution to the structuration of starch matrices in the presence of flavour
2015
The effect of hydrothermal treatments and flavours addition on starch structure and its physical properties were studied. Native wheat starch was treated at 2 different hydrations (water-starch ratios: 50/50 and 80/20 g w/w) and temperatures (65 and 85 °C) in the presence of flavours (ethyl hexanoate and 2-hexanone). The freshly prepared samples were subjected to DSC and flavour analysis. Flavour inclusion complex could not be detected by DSC, however the result of flavour analysis proved that there were flavours interactions with starch. Both ethyl hexanoate and 2-hexanone interacted with starch at similar rates. The highest flavour loss was found in the samples at high hydration and heate…
New solutions of preparation and activation of surfaces
2017
Organic coatings applied on the surface of cast iron pipes ensure very good chemical and anti-corrosion protection against aggressive effluents. To improve adherence between coating (epoxy) and substrate, a surface preparation is required. Among conventional processes shot blasting has emerged as the most efficient and cheapest solution for ensuring stripping while generating adapted roughness. However, as it may enhance both mechanical anchorage and chemical bonding a better understanding of these phenomena should be developed. Besides new eco-friendly alternatives were investigated.Indeed, new techniques were evaluated, i.e. laser structuring and an ultra-high pressure water jet whose maj…
Du comptage ponctuel à l'affectation par simulation multi-agents : application à la circulation routière de la ville de Dijon
2014
A travers une démarche expérimentale de simulation de la circulation routière pour estimer les pollutions atmosphériques en milieu urbain, cette proposition questionne les opportunités qu'offre la simulation multi-agents pour intégrer des données d'observations du trafic routier au sein d'un système d'information géographique. Pour cela, la construction du modèle d'affectation s'est faite en deux étapes : une première, d'acquisition et de structuration des données de comptages et une seconde visant à interfacer ces données au sein d'une plateforme de simulation multi-agents pour en reproduire la variabilité intra journalière et la fréquentation routière.
L'étranger prostitué en droit français : une protection en demi-teinte
2019
International audience
Tomographic image processing for the morphological and metrological study of Valsalva sinuses
2012
This Phd thesis deals with the design and the use of image processing tools in order to allow a reliable and objective study of the sinuses of Valsalva which are important cavities of the aortic root. The proposed methods can be applied on cine-MR sequences and CT examinations without any change in the settings between two examinations.Firstly, we studied the morphology of this anatomical area and its constant properties in all images of the dataset. Sinuses are one of the main bright organs with limited movements. Hence a new algorithm has been designed. It detects and characterizes each bright organ by a single trajectory. Various tools of mathematical morphology are used for this step, a…
Utilisation of natural carotenoids from Momordica cochinchinensis (gac) as health compounds : extraction and bioactvity depending on the origin and o…
2014
The aril of Momordica cochinchinensis (gac), plant from the Cucurbitaceae family, is the richest source of lycopene and β-carotene, which are a strong antioxidant and a pro-vitamin A, respectively, interesting for health-complements. First, a process of soft extraction-fractionation was developed for extracting effectively the natural carotenoids from gac without loss of their original quality. Then, the lycopene and β-carotene extracted from gac were analyzed and characterized. At least 95% of the extracts were composed of the all-trans isomer. They were not degraded during the heat-treatment mimicking formulation processing. Their thermal stereo-mutation was evaluated. Lycopene is more an…
Foodborne pathogens inactivation in low-water activity foods
2016
Dried food products are common in food industry. Nevertheless, their safety is not well insured, involving numerous outbreaks every years around the world. Particularly, two pathogenic bacteria are of interest, one of them due to its number of cases, Salmonella enterica, and the other one due to its ability to survive environmental perturbations, Cronobacter spp.. A deeper comprehension of drying and heat treatment in dried state impact could lead to an optimization of drying and heating processes, insuring food safety. In the first instance, drying was considered as a supplementary decontamination step by optimizing its conditions of use. In a second phase, the rehydration impact was studi…