Search results for "transformation"
showing 10 items of 1634 documents
Zusammenfassung der Diskussion zum Thema: „Fortschritte auf dem Gebiet der parenteralen Ernährung“ und „Parenterale Ernährung unter speziellen klinis…
1977
LACKNER: DUDRICK emphasized the attempts to improve the immune competence It has been shown by Dr. CARPENTIER et al. from Belgium—(2)—that in improving the nitrogen balance he could directly increase the lymphocyte function which was measured in vitro by means of the lymphocyte transformation test.
Abstract 2903: IMAB362, a novel first-in-class monoclonal antibody for treatment of pancreatic cancer
2014
Abstract Pancreatic ductal adenocarcinoma (PDAC), the most frequent subtype (>80%) of pancreatic cancer (PC) is characterized by a generally lethal progress within a short period of time after primary diagnosis. Despite high efforts, the treatment options are very limited and mainly of palliative nature. Therefore, we investigated whether IMAB362 might represent a potential treatment option in this patient population. IMAB362 is a highly potent and tumor-cell selective therapeutic antibody which is currently in clinical development in gastro-esophageal cancer (in phase II and IIb trials). IMAB362 is directed against the tight junction molecule CLDN18.2, a proliferation-promoting tran…
Proteasome-inhibited dendritic cells demonstrate improved presentation of exogenous synthetic and natural HLA-class I peptide epitopes.
2004
The design and successful clinical implementation of cancer vaccines targeting the induction of T-cell mediated immunity is a rapidly evolving field that is hampered by an empirical selection of antigen and adjuvant. In particular, vaccines using defined tumor-associated peptide epitopes elicit only a restricted T-cell repertoire in a minority of patients. In this regard, vaccines comprising the whole spectrum of antigens presented by individual autologous tumors would be advantageous. In an in vitro model, we evaluated the capacity of naturally processed Epstein-Barr virus-transformed B-lymphoblastoid-cell line (LCL)-derived peptides to activate virus-specific CD8+ T cells of seropositive …
CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes.
1992
Herpes virus saimiri (HVS) immortalizes T lymphocytes from a variety of primates and causes acute T cell lymphomas and leukemias in nonnatural primate hosts. Here we have analyzed the requirements for growth of three HVS-transformed human T cell lines. The cells expressed the phenotype of activated T cells: two were CD4+, and one was CD8+. All three cells responded to all allogeneic human cell lines tested with enhanced proliferation, production of interleukin 2 (IL-2), and increased expression of the IL-2 receptor. Binding of CD2 to its ligand CD58 was the critical event mediating stimulation because: (a) monoclonal antibodies (mAbs) to CD2 and to CD58, but not to a variety of other surfac…
Herpes virus saimiri-transformed human T lymphocytes: normal functional phenotype and preserved T cell receptor signalling
1993
Herpes virus saimiri (HVS), a primate herpes virus, transforms human CD4+ and CD8+ T lymphocytes to continuous growth in vitro. We have previously shown that HVS-transformed human T cells (HVS-T cells) respond to stimulation via CD2 with autocrine growth. In the present study we have investigated the functional characteristics of HVS-T cells. We describe that these cells can perform all the functions of normal T cells, i.e. cytokine secretion, cytotoxicity, and exocytosis of granule esterases. All these activities can be triggered via CD2 by binding to its natural ligand or via the TCR, e.g. by anti-TCR antibodies, by recognition of a bacterial superantigen and by MHC-restricted recognition…
Sixfold improved single particle measurement of the magnetic moment of the antiproton
2017
Our current understanding of the Universe comes, among others, from particle physics and cosmology. In particle physics an almost perfect symmetry between matter and antimatter exists. On cosmological scales, however, a striking matter/antimatter imbalance is observed. This contradiction inspires comparisons of the fundamental properties of particles and antiparticles with high precision. Here we report on a measurement of the g-factor of the antiproton with a fractional precision of 0.8 parts per million at 95% confidence level. Our value /2=2.7928465(23) outperforms the previous best measurement by a factor of 6. The result is consistent with our proton g-factor measurement gp/2=2.7928473…
On the Computational Aspects of a Symmetric Multidomain Boundary Element Method Approach for Elastoplastic Analysis
2011
The symmetric boundary element method (SBEM) is applied to the elasto-plastic analysis of bodies subdivided into substructures. This methodology is based on the use of: a multidomain SBEM approach, for the evaluation of the elastic predictor; a return mapping algorithm based on the extremal paths theory, for the evaluation of inelastic quantities characterizing the plastic behaviour of each substructure; and a transformation of the domain inelastic integrals of each substructure into corresponding boundary integrals. The elastic analysis is performed by using the SBEM displacement approach, which has the advantage of creating system equations that only consist of nodal kinematical unknowns…
Involvement of acyl coenzyme A oxidase isozymes in biotransformation of methyl ricinoleate into gamma-decalactone by Yarrowia lipolytica.
2000
ABSTRACT We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes ( POX1 through POX5 ) (H. Wang et al., J. Bacteriol. 181:5140–5148, 1999). Here, these mutants were studied for lactone production. Monodisrupted strains produced similar levels of lactone as the wild-type strain (50 mg/liter) except for Δ pox3 , which produced 220 mg of γ-decalactone per liter after 24 h. The Δ pox2 Δpox3 double-disrupted strain, although slightly affected in growth, produced about 150 mg of lactone per liter, indicating that Aox2p was not essential for the biotra…
La medición de la felicidad en el trabajo y sus antecedentes : un estudio empírico en el area de alergología de los hospitales públicos españoles
2014
La búsqueda de la felicidad en el trabajo es un objetivo de enorme importancia para muchas personas y organizaciones. Sin embargo, existe una carencia importante la investigación acerca de cómo aumentarla (Chivato Pérez et al., 2011), así como una amplia dispersión de medidas relacionadas (Hackman, 2009). No se conoce ninguna medida que recoja con la suficiente amplitud la medición de la felicidad en el trabajo (Fisher, 2010), por lo que en este estudio proponemos un modelo integrativo que nos aporte la medida de este nuevo constructo. Proponemos que la felicidad en el trabajo se compone de tres constructos ya consolidados en la literatura. La primera hipótesis de esta investigación es que …
A Framework for a Smart City Design : Digital Transformation in the Helsinki Smart City
2019
Recently, there has been substantial interest in the concept of a smart city, as it has been a viable solution to the dilemmas created by the urbanization of cities. Digital technologies—such as Internet-of-Things, artificial intelligence, big data, and geospatial technologies—are closely associated with the concept of a smart city. By means of modern digital technologies, cities aim to optimize their performance and services. Further, cities actively endorse modern digital technologies to foster digitalization and the emergence of data-based innovations and a knowledge economy. In this paper, a framework for a smart city design is presented. The framework considers a smart city from the pe…