Search results for "transformation"

Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor.

2001

Abstract Background/Aims : Cultured human hepatocytes are considered a close model to human liver. However, the fact that hepatocytes are placed in a microenvironment that differs from that of the cell in the liver raises the question: to what extent does drug metabolism in vitro reflect that of the liver in vivo? This issue was examined by investigating the in vitro and in vivo metabolism of aceclofenac, an analgesic/anti-inflammatory drug. Methods : Hepatocytes isolated from programmed liver biopsies were incubated with aceclofenac, and the metabolites formed were investigated by HPLC. During the course of clinical recovery, patients were given the drug, and the metabolites, largely prese…

Natural polyphenols in cancer therapy.

2011

Natural polyphenols are secondary metabolites of plants involved in defense against different types of stress. Extracts containing these compounds have been used for thousands of years in traditional eastern medicine. Polyphenols act on multiple targets in pathways and mechanisms related to carcinogenesis, tumor cell proliferation and death, inflammation, metastatic spread, angiogenesis, or drug and radiation resistance. Nevertheless, reported effects claimed for polyphenols are controversial, since correlations between in vitro effects and in vivo evidence are poorly established. The main discrepancy between health claims versus clinical observations is the frequent use of nonphysiological…

Distribution of clozapine and desmethylclozapine between blood and brain in rats.

1999

Desmethylclozapine is the major metabolite of clozapine in serum. Although the metabolite is pharmacologically active in vitro, the occurrence of desmethylclozapine in brain under steady-state conditions and its role for clinical actions of clozapine are unclear. In this study 20 male Sprague-Dawley rats received five oral doses of clozapine 20 mg/kg at 1.5-h intervals. At 0.5, 1, 2 and 5 h after the last administration, at a time four animals were killed for analysis of clozapine and desmethylclozapine concentrations in serum and brain. The treatment yielded steady-state serum concentrations of clozapine that are considered as therapeutically effective in man. Desmethylclozapine concentrat…

The on-line coupled atmospheric chemistry model system MECO(n) – Part 5: Expanding the Multi-Model-Driver (MMD v2.0) for 2-way data exchange includin…

2018

Abstract. As part of the Modular Earth Submodel System (MESSy), the Multi-Model-Driver (MMD v1.0) was developed to couple online the regional Consortium for Small-scale Modeling (COSMO) model into a driving model, which can be either the regional COSMO model or the global European Centre Hamburg general circulation model (ECHAM) (see Part 2 of the model documentation). The coupled system is called MECO(n), i.e., MESSy-fied ECHAM and COSMO models nested n times. In this article, which is part of the model documentation of the MECO(n) system, the second generation of MMD is introduced. MMD comprises the message-passing infrastructure required for the parallel execution (multiple programme mul…

Key advantages of the leverage points perspective to shape human-nature relations

2021

This perspective paper synthesises the special issue 'Human-nature connectedness as a leverage point for sustainability transformation'. Based on the articles in this special issue, we aim to foster the operationalisation of the leverage points perspective to shape human-nature relations to enable sustainability transformations. Specifically, we draw on four key advantages of the leverage points perspective: (i) the explicit recognition of deep leverage points; (ii) the ability to examine the interactions between shallow and deep system changes; (iii) the combination of causal and teleological modes of research; and (iv) the ability to function as a methodological boundary object. The contr…

Transformations organisationnelles au coeur des ESN performantes : une étude exploratoire

2022

Possibilities and challenges in sustained capacity-building in early childhood education and care (ECEC) institutions: ECEC leaders’ perspectives

2020

This paper investigates early childhood education and care (ECEC) institutions’ opportunities to build a learning organization and master future innovations by focusing on core components, implementation drivers, leadership, and collective collaborative systems. The paper is based on results from semi-structured interviews with ten ECEC leaders from three different municipalities in Norway that had taken part in the Being Together (BT) innovation five years earlier. Three areas were identified as crucial for the continuation of ECEC teachers’ capacity building: (1) a strong focus on implementation processes and sustainability; (2) transformational leadership; and (3) developing professional…

Innovation: transforming hierarchies in South Asia

2014

This special issue examines innovation as social change in South Asia. From an anthropological micro perspective, innovation is moulded by social systems of value and hierarchy and simultaneously potentially transforms them. The articles in this special issue examine a number of innovations in South Asian contexts: the printing press's changing technology and its intersections with communal and language ideologies in India (Peterson); mobile telephony, gender, and kinship in West Bengal (Tenhunen); microcredit and its relationship with social capital in Bangladesh (Uddin); imbalanced sex ratios and the future of marriage payments in north-western India (Jeffery); and how alternative dispute…

Effective leadership in teams: a simple model

2013

This article explores the determinants of effective leadership in a team of production. We obtain that for leadership to be effective, the leader must be at least as productive as the follower. In the case of a charismatic leader, we obtain that efficiency can be restored with a homogeneous team.

Civil society organizations and social innovation. How and to what extent are they influencing social and political change?

2017

This study aims to understand how civil society organizations (CSOs) perform and influence public arenas. The focus of this paper is the transformative scope of social innovation initiatives promoted by CSOsin two public arenas in Brazil: the fight against electoral corruption and the protection of children and adolescents’ rights. The research consisted of three stages: 1) controversy mapping to understand the configuration ofthese public arenas and compare the trajectories of the public problems studied; 2) observation of the “field of experience” of some CSOs that perform in these arenas; and 3) analysis of “political grammars” produced in public arenas, connecting them to the performanc…