Search results for "transformation"
showing 10 items of 1634 documents
Metabolism of chlorobenzene and hexachlorobenzene by the zebra fish, Brachydanio rerio.
1989
It is now becoming evident that in many cases metabolites have a greater toxic potential than the parent xenobiotic exposed. For this reason, the knowledge of biotransformation pathways of xenobiotics plays a substantial role in environmental monitoring programs. The zebra fish (Brachydanio rerio, Hamilton-Buchanan) has received increased attention as a model species for freshwater fish in environmental surveillance programs to evaluate potential health and impacts of anthropogenic chemicals. The metabolism of phenol and various substituted phenols in zebra fish has recently been studied. The purpose of the present study was to examine the metabolism of chlorobenzene and hexachlorobenzene (…
LATE MORTALITY OF HEMORRHAGIC TRANSFORMATION OF ISCHEMIC STROKE
2012
Introduction. Hemorrhagic transformation (HT), a complication of ischemic stroke (IS) is supposed to influence patient’s prognosis. Aim of our study was to evaluate, in a hospital-based series of patients not treated with thrombolysis, the relationship between HT and late mortality. Methods. Mortality of individuals with spontaneous HT was compared to that of individuals without. Medical records of patients diagnosed with anterior IS during the period 2004-2006 were reviewed. Living status was obtained from the public record office of the municipality of Palermo or indirectly by telephone interview. Outcome measure was 90 days survival after IS onset. Kaplan-Meier estimates were used to con…
Molecular hybridization techniques in current diagnosis of chronic hepatitis B in childhood.
1992
Following the cloning and sequencing of the hepatitis B virus genome, molecular hybridization techniques have been established to detect hepatitis B virus (HBV) DNA in serum and liver tissue. Analyses can be performed by dot blot, Southern blot and in situ hybridization. HBV DNA is regarded to be the most sensitive marker of viral replication and infectivity which was previously related to the presence of hepatitis B e antigen in serum and hepatitis B core antigen in liver cells. In liver tissue different molecular patterns can be recognized as free viral DNA and integrated sequences. Furthermore, introduction of the polymerase chain reaction allows the detection of very small amounts of vi…
In vitro production of anti-neutrophilocyte-cytoplasm-antibodies (ANCA) by Epstein-Barr virus-transformed B-cell lines in Wegener's granulomatosis.
1991
The frequent detection of anti-neutrophilocyte-cytoplasm-antibodies (ANCA) in patients with Wegener's granulomatosis (WG) led to the supposition that this disease might be of autoimmune nature. For some authors assume that Epstein-Barr virus (EBV) infection of human B-lymphocytes besides polyclonal activation could reveal the cryptic immune status against different autoantigens in patients with autoimmune diseases we investigated EBV-transformed B-lymphocytes from patients with Sjögren's syndrome, mixed connective tissue disease, WG and healthy blood donors. Two stable B-cell lines (Ho3, We1) could be established. Inhibition experiments showed that antibodies produced by transformed B-lymph…
Biophysical parameter retrieval with warped Gaussian processes
2015
This paper focuses on biophysical parameter retrieval based on Gaussian Processes (GPs). Very often an arbitrary transformation is applied to the observed variable (e.g. chlorophyll content) to better pose the problem. This standard practice essentially tries to linearize/uniformize the distribution by applying non-linear link functions like the logarithmic, the exponential or the logistic functions. In this paper, we propose to use a GP model that automatically learns the optimal transformation directly from the data. The so-called warped GP regression (WGPR) presented in [1] models output observations as a parametric nonlinear transformation of a GP. The parameters of such prior model are…
Genetic Determined Downregulation of Both Type 1 and Type 2 Cytokine Pathways Might Be Protective against Pancreatic Cancer
2009
Many cytokine polymorphisms have been studied for associations with susceptibility to breast, gastric, liver, lung, prostate, and ovarian cancer without conclusive results. The cytokine network, indeed, is characterized by complex interactions, and the final biological effect of a single genetic variation depends on the balance among different molecular signals. As is well known, Th1/Th2 cytokine unbalanced production might predispose to different pathologies, cancer included. In general, a prolonged type 1 inflammatory response might allow that cells accumulating enough "genetic hits" are promoted to neoplastic transformation. On the other hand, IL-13-producing cells through the IL-13/IL-4…
Simulations of an inhomogeneous stellar wind interacting with a pulsar wind in a binary system
2014
Binary systems containing a massive star and a non-accreting pulsar present strong interaction between the stellar and the pulsar winds. The properties of this interaction, which largely determine the non-thermal radiation in these systems, strongly depend on the structure of the stellar wind, which can be clumpy or strongly anisotropic, as in Be stars. We study numerically the influence of inhomogeneities in the stellar wind on the structure of the two-wind interaction region. We carried out for the first time axisymmetric, relativistic hydrodynamical simulations, with Lorentz factors of ~6 and accounting for the impact of instabilities, to study the impact in the two-wind interaction stru…
Absorption by black hole remnants in metric-affine gravity
2019
Using numerical methods, we investigate the absorption properties of a family of nonsingular solutions {which arise in different metric-affine theories, such as quadratic and Born-Infeld gravity.} These solutions continuously interpolate between Schwarzschild black holes and naked solitons with wormhole topology. The resulting spectrum is characterized by a series of quasibound states excitations, associated with the existence of a stable photonsphere.
Differential equations for Feynman integrals beyond multiple polylogarithms
2017
Differential equations are a powerful tool to tackle Feynman integrals. In this talk we discuss recent progress, where the method of differential equations has been applied to Feynman integrals which are not expressible in terms of multiple polylogarithms.
ON THE DEFORMATION QUANTIZATION OF AFFINE ALGEBRAIC VARIETIES
2004
We compute an explicit algebraic deformation quantization for an affine Poisson variety described by an ideal in a polynomial ring, and inheriting its Poisson structure from the ambient space.