Search results for "transkriptio"
showing 10 items of 10 documents
Sovittaminen teoksen rekontekstualisaationa : Ferruccio Busonin esteettis-filosofisten näkemysten heijastuminen Bach-Busonin Chaconnessa
2006
Longevity-related molecular pathways are subject to midlife “switch” in humans
2019
Emerging evidence indicates that molecular aging may follow nonlinear or discontinuous trajectories. Whether this occurs in human neuromuscular tissue, particularly for the noncoding transcriptome, and independent of metabolic and aerobic capacities, is unknown. Applying our novel RNA method to quantify tissue coding and long noncoding RNA (lncRNA), we identified ~800 transcripts tracking with age up to ~60 years in human muscle and brain. In silico analysis demonstrated that this temporary linear “signature” was regulated by drugs, which reduce mortality or extend life span in model organisms, including 24 inhibitors of the IGF‐1/PI3K/mTOR pathway that mimicked, and 5 activators that oppos…
Happiness is... a good transcription : reconsidering the Beatles sheet music publications
2006
Hankkiessaan Beatles-nuotinnoksen käsiinsä ei kuluttajalla välttämättä ole ollenkaan käsitystä siitä, minkä tasoinen kulloinenkin nuotinnos on, eli kuinka luotettava se on verrattuna alkuperäiseen lähteeseen eli levyyn. Musiikin käyttäjälle olisi varmasti paljon hyötyä ja iloa siitä, jos nuotit vastaisivat paremmin levyjä – valitettavasti vain julkaistut nuotinnokset ovat suurelta osin puutteellisia ja jättäneet paljon toivomisen varaa. Myös maailmalla erittäin paljon myydyn ja tunnetun ”The Beatles Complete Scoresin” transkriptiot ovat monelta osin kaukana siitä mitä levyillä todellisuudessa on. Nuottien kustantaminen on yhä edelleenkin suurta bisnestä, mutta sitä ei ole kuitenkaan jostain…
SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.
2006
Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A corepressor complex recruits histone deacetylases and in many cases represses transcription. Here, we report that SAP30L, a close homolog of Sin3-associated protein 30 (SAP30), interacts with several components of the Sin3A corepressor complex. We show that it binds to the PAH3/HID (Paired Amphipathic Helix 3/Histone deacetylase Interacting Domain) region of mouse Sin3A with residues 120–140 in the C-terminal part of the protein. We provide evidence that SAP30L induces…
Distribution and dynamics of transcription-associated proteins during parvovirus infection.
2012
Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins. peerReviewed
TCF7-transkriptiotekijän merkitys T-auttajasolujen erilaistumisessa
2009
Kaikki verisolut kehittyvät luuytimen hematopoieettisista kantasoluista. Kypsyessään solut ohjelmoituvat tiettyyn kehityslinjaan ympäristöstään saamiensa signaalien ohjaamana. T-lymfosyytit kypsyvät kateenkorvassa saaden signaaleja kateenkorvan epiteelin soluilta. Usean kehitysvaiheen aikana soluista valitaan ne, jotka tunnistavat vieraat antigeenit, eivätkä sitoudu liian voimakkaasti omien solujen rakenteisiin. Kypsyttyään naiivit T-auttajasolut (Th) vapautetaan elimistöön, jossa ne antigeeninsä kohdattuaan aktivoituvat ja erilaistuvat Th1- tai Th2-soluiksi ympäristöstään saamiensa sytokiinisignaalien ohjaamaana. T-auttajasolujen tuottamat sytokiinit ohjaavat muita immuunipuolustuksen solu…
De novo transcriptome assembly of a facultative parasitic nematode Pelodera (syn. Rhabditis) strongyloides
2018
Pelodera strongyloides is a generally free-living gonochoristic facultative nematode. The whole genomic sequence of P. strongyloides remains unknown but 4 small subunit ribosomal RNA (ssrRNA) gene sequences are available. This project launched a de novo transcriptome assembly with 100 bp paired-end RNA-seq reads from normal, starved and wet-plate cultured animals. Trinity assembly tool generated 104,634 transcript contigs with N50 contig being 2195 bp and average contig length at 1103 bp. Transcriptome BLASTX matching results of five nematodes (C. elegans, Strongyloides stercoralis, Necator americanus, Trichuris trichiura, and Pristionchus pacificus) were consistent with their evolutionary …
Toxicity of biomining effluents to Daphnia magna: Acute toxicity and transcriptomic biomarkers
2018
Increasing metal consumption is driving the introduction of new techniques such as biomining to exploit low grade ores. The biomining impacts notably aquatic ecosystems, yet, the applicability of ecotoxicological tests to study the complex mixture effects of mining waters is insufficiently understood. The aim of the present work was to test if transcriptomic biomarkers are suitable and sensitive for the ecotoxicity assessment of biomining affected waters. The study site had been affected by a multimetal biomine, and the studied water samples formed a concentration gradient of contamination downstream from the biomining site. Cadmium and nickel were used as positive controls in the toxicity …
Toxicity of biomining effluents to Daphnia magna : Acute toxicity and transcriptomic biomarkers
2018
Increasing metal consumption is driving the introduction of new techniques such as biomining to exploit low grade ores. The biomining impacts notably aquatic ecosystems, yet, the applicability of ecotoxicological tests to study the complex mixture effects of mining waters is insufficiently understood. The aim of the present work was to test if transcriptomic biomarkers are suitable and sensitive for the ecotoxicity assessment of biomining affected waters. The study site had been affected by a multimetal biomine, and the studied water samples formed a concentration gradient of contamination downstream from the biomining site. Cadmium and nickel were used as positive controls in the toxicity …
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies
2023
The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of oncogenic NRF2 signaling. We identified an immunoevasive phenotype where high NRF2 activity is associated with low interferon-gamma (IFNγ), HLA-I expression and T cell and macrophage infiltration in squamous malignancies of the lung, head and neck area, cervix and esophagus. Squamous NRF2 overactive tumors comprise a molecular phenotype with SOX2/TP63 amplification, TP53 mutation and CDKN2A loss. These immune cold NRF2 hyperactive diseases are a…