Search results for "transplantation"
showing 9 items of 2019 documents
How important is the role of iterative liver direct surgery in patients with hepatocellular carcinoma for a transplant center located in an area with…
2022
IntroductionHepatocellular carcinoma (HCC) accounts for nearly 90% of primary liver cancers, with estimates of over 1 million people affected by 2025. We aimed to explore the impacting role of an iterative surgical treatment approach in a cohort of HCC patients within the Milan criteria, associated with clinical risk factors for tumor recurrence (RHCC) after liver transplant (LT) and loco-regional therapies (LRT), as well as liver resection (LR) and/or microwave thermal ablation (MWTA).MethodsWe retrospectively analyzed our experience performed during an 8-year period between January 2013 and December 2021 in patients treated for HCC, focusing on describing the impact on preoperative end-st…
Relationship of transforming growth factor-beta1 with tumor necrosis factor-alpha and endothelial activation in patients with stable renal transplant…
2008
Impacto del quimerismo hematopoyético precoz en el injerto tras trasplante alogénico de progenitores de sangre de cordón umbilical de donante no empa…
2013
El trasplante de sangre de cordón umbilical (TSCU) ha experimentado un auge muy importante en los últimos años como alternativa a la médula ósea y sangre periférica, debido a la dificultad de encontrar donantes altruistas de estas fuentes de progenitores hematopoyéticos. Los datos clínicos disponibles hasta la fecha muestran una supervivencia libre de enfermedad similar a la observada con el trasplante de médula ósea (TMO) o sangre periférica (TSP). Sin embargo, como consecuencia de la baja dosis celular contenida en la SCU, la tasa de fallo de injertos es más elevada y el tiempo hasta la recuperación de la neutropenia más prolongado. Gran parte de la investigación en el terreno del TSCU se…
Fertility and immunosuppression in allogeneic uterus transplantation
2015
A pesar de los avances en medicina reproductiva alcanzados durante las últimas tres décadas, la esterilidad absoluta de origen uterino (AUFI, por sus siglas en inglés), a día de hoy, carece de tratamiento. Ésta, puede ser causada tanto por la ausencia del útero (congénita o adquirida) o la no funcionalidad del mismo [1, 2]. Cálculos en el Reino Unido han demostrado que hay alrededor de 12000 a 15000 mujeres en edad reproductiva con infertilidad uterina en dicho país [3]. No hay cálculos correspondientes a España, pero extrapolando datos sobre prevalencia de causas de AUFI, se estima que puede haber alrededor de 2000-3000 mujeres en edad fértil que no tienen ninguna oportunidad de ser biológ…
Non-HLA Antibodies in Hand Transplant Recipients Are Connected to Multiple Acute Rejection Episodes and Endothelial Activation
2022
The role of anti-HLA antibodies in transplant rejection is well-known but the injury associated with non-HLA antibodies is now widely discussed. The aim of our study was to investigate a role of non-HLA antibodies in hand allografts rejection. The study was performed on six patients after hand transplantation. The control group consisted of: 12 kidney transplant recipients and 12 healthy volunteers. The following non-HLA antibodies were tested: antibody against angiotensin II type 1 receptor (AT1R-Ab), antibody against endothelin-1 type-A-receptor (ETAR-Ab), antibody against protease-activated receptor 1 (PAR-1-Ab) and anti-VEGF-A antibody (VEGF-A-Ab). Chosen proinflammatory cytokines (Il-1…
Incidence and dynamics of active cytomegalovirus infection in allogeneic stem cell transplant patients according to single nucleotide polymorphisms i…
2014
Single nucleotide polymorphisms (SNPs) in genes involved in the activation or regulation of innate and adaptive immune responses may modulate the susceptibility to and the natural history of certain chronic viral infections. The current study aimed to investigate whether donor and recipient SNPs in the chemokine receptor 5 (rs1800023), monocyte chemoattractant protein 1 (rs13900), interleukin-10 (rs1878672), and Toll-like receptor 9 (rs352140) genes would exert any influence on the rate of incidence and features of CMV DNAemia in the allogeneic stem cell transplantation setting. This was a retrospective observational multicenter study. The cohort consisted of 102 non-consecutive allogeneic …
Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus
2010
Apoptosis is a fundamental host defence mechanism against invading microbes. Inactivation of NF-kappaB attenuates encephalomyocarditis virus (EMCV) virulence by triggering rapid apoptosis of infected cells, thereby pre-emptively limiting viral replication. Recent evidence has shown that hypoxia-inducible factor (HIF) increases NF-kappaB-mediated anti-apoptotic response in clear-cell renal cell carcinoma (CCRCC) that commonly exhibit hyperactivation of HIF due to the loss of its principal negative regulator, von Hippel-Lindau (VHL) tumour suppressor protein. Here, we show that EMCV challenge induces a strong NF-kappaB-dependent gene expression profile concomitant with a lack of interferon-me…
Antiviral prophylaxis in patients with haematological malignancies and solid tumours: Guidelines of the Infectious Diseases Working Party (AGIHO) of …
2006
Morbidity and mortality in patients with malignancies are increased by viral infections. These mostly are reactivations of asymptomatic latent infections. They primarily concern clinical entities associated with the reactivation of herpes viruses, such as varicella zoster virus (VZV) and cytomegalovirus (CMV). Respiratory tract infections caused by influenza, parainfluenza or respiratory syncytial virus (RSV) are less common. Since reactivation of latent infections has major clinical impact, antiviral prophylaxis is an attractive approach for patients expecting immunosuppression. The main risk factor for clinically relevant reactivation is profound disruption of cellular immune response. Du…
Pēcoperācijas perioda izvērtējums pēc radzenes transplantācijas vispārējā anestēzijā
2020
Bakalaura darba tēma ir “Pēcoperācijas perioda izvērtējums pēc radzenes transplantācijas vispārējā anestēzijā”. Darba tēmas aktualitāte ir tajā, ka radzenes transplantācijas operācijas visā pasaulē un Latvijā tiek veiktas arvien vairāk, tāpēc ir būtiski novērtēt pēcoperācijas periodu pēc šīm operācijām, lai izvērtēt aprūpes procesu, pacientu sūdzības un dokumentācijas kvalitāti un nepieciešamības gadījumā veikt uzlabojums. Darba mērķis ir izvērtēt pēcoperācijas periodu pacientam pēc radzenes transplantācijas operācijas vispārējā anestēzijā. Bakalaura darba mērķa saniegšanai autore izvirzija sekojošus darba uzdevumus - apkopot un analizēt zinātnisko literatūru par radzenes transplantāciju un…