Search results for "trp"

showing 2 items of 102 documents

A new actor involved in hypothalamic glucose detection : the Transient Receptor Potential Canonical (TRPC) channels

2015

Hyperglycemia is detected and integrated by the mediobasal hypothalamus (MBH) which, in turn, inhibits food intake and triggers insulin secretion. The MBH houses specialized glucose-sensitive (GS) neurons, which directly or indirectly modulate their electrical activity in response to changes in glucose level. In a first study, we hypothesized that indirect detection of glucose by MBH GS neurons involves the secretion of endozepine by astrocytes, a gliotransmitter known to inhibit food intake in response to hyperglycemia. The present work shows that endozepines selectively activate anorexigenic MBH pro-opiomelanotortine (POMC) neurons. In the second study, we show that the direct detection o…

Glucose-sensing neuronsEspèces actives de l’oxygèneEndozépines[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]Glucose detectionHypothalamusHoméostasie énergétiqueTRPC channelsCanaux TRPCAstrocytesEnergy homeostasisNeurones gluco-sensibles[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Détection du glucoseReactive oxygen species
researchProduct

Identification of two new mutations in TRPS 1 gene leading to the tricho-rhino-phalangeal syndrome type I and III.

2009

GeneticsAdolescentBase SequenceLanger-Giedion SyndromeDNA Mutational AnalysisMolecular Sequence DataInfantBiologymedicine.diseaseDNA-Binding ProteinsRepressor ProteinsSettore MED/38 - Pediatria Generale E SpecialisticaSettore MED/03 - Genetica MedicaMutationGeneticsmedicineTricho–rhino–phalangeal syndromeHumansIdentification (biology)FemaleTRICHO-RHINO-PHALNAGEAL SYNDORME TRPS GENEChildGeneGenetics (clinical)Transcription FactorsAmerican journal of medical genetics. Part A
researchProduct