Search results for "tuli"
showing 10 items of 223 documents
Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells
2010
A novel approach to circumvent multidrug resistance is hybridization of natural products in dimers. We analyzed homodimers of two artesunic acid molecules and heterohybrids of artesunic acid and betulin in human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR5000 leukemia cells. Multidrug-resistant cells were not cross-resistant to the novel compounds. Collateral sensitivity was observed for artesunic acid homodimer. Artesunic acid and artesunic acid homodimer induced G0/G1 cell cycle arrest, apoptosis, and formation of reactive oxygen species.
INTRA- AND INTERSPECIFIC VARIATION IN INTERNAL STRUCTURES OF THE GENUSSTENOSARINA(BRACHIOPODA, TEREBRATULIDA) USING LANDMARKS
2001
Abstract Although a number of brachiopod genera have been defined mainly from their internal structures, the fixity of those structures has rarely been investigated. Variability of the rather simple loops of two New Caledonian species of the Recent genus Stenosarina (Terebratulida), one species having a variant with endemic morphology, provides insight into the relationship between the two species. Procrustes methods based on landmarks are used. Intra-population variability is found to be of the same order of magnitude as inter-population variability. Moreover, the morphological distance between the endemic variant and the other specimens is greater than the distance between the two species…
Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2
2005
In the present study, we report that three new lupane triterpenes (1-3), in addition to 16 known ones (4-19), were isolated from the root bark of Maytenus cuzcoina and the leaves of Maytenus chiapensis. Their structures were elucidated by spectral analysis, including homonuclear and heteronuclear correlation NMR experiments (COSY, ROESY, HSQC, and HMBC). The natural compounds and derivatives 6a, 6b, 9a, and 9b have been tested for potential anti-inflammatory activity, and several compounds including 3-epicalenduladiol (2), 11alpha-hydroxy-glochidone (3), rigidenol (6), acetoxy-rigidenol (6a), 11alpha-acetoxy-30-chloro-3-oxo-lup-20(29)-ene (6b), betulin (9), 28-acetoxy-betulin (9a), epibetul…
Jekaterinai Ripai veltīto apsveikumu kolekcija
2018
Raksts par vēsturnieci, bijušo Latvijas Valsts Universitātes Vēstures un filoloģijas fakultātes dekāni (1961-1963) un Studentu zinātniskās biedrības sekcijas zinātnisko vadītāju docenti Jekaterinu Ripu (1902-1993) un viņai veltīto vēstuļu un apsveikumu kolekciju, kas glabājas Latvijas Universitātes Muzeja Vēstures kolekcijā.
Pluralismo político y rol del moderador en tertulias televisivas: Al Rojo Vivo y Las Mañanas de Cuatro
2019
Las tertulias televisivas poseen gran relevancia en el nuevo ciclo político abierto en España en 2014. Con vistas a analizar el grado de pluralismo político y el rol del moderador que se despliega en ellas, se ha tomado una muestra de 50 programas (25 de “Al Rojo Vivo” y 25 de “Las Mañanas de Cuatro”). La perspectiva es cualitativa respecto al alcance del marco permitido y cuantitativa en cuanto al tratamiento que reciben los partidos políticos. Las variables registradas están relacionadas con quién, cuánto y cómo interviene en el programa. Se ha obtenido el número de intervenciones que realiza un partido por cada contraargumento que recibe de los periodistas. Del análisis se extraen conclu…
La mascota del magistrado
2010
Es bien conocida la importancia de las tertulias en el siglo XVIII. Sin llegar a la trascendencia de las francesas, también las hubo en España, especialmente en el reinado de Carlos III. Pero en el caso analizado, la tertulia semanal en casa del abogado José Bermúdez tiene un carácter político (presencia de embajadores), cultural (origen de la primera biografía de Cervantes) y de entretenimiento. El presente artículo centra su atención en este último aspecto. (A)
Cytotoxic phytochemicals from the crude extract of Tetrapleura tetraptera fruits towards multi-factorial drug resistant cancer cells.
2020
Abstract Ethnopharmacological relevance Tetrapleura tetraptera is an African medicinal spice used in traditional medicine to treat several ailments including cancer. Aim of the study The present study was designed to evaluate the cytotoxicity of the dichloromethane-methanol (1:1) extract of the fruits of Tetrapleura tetraptera (TTF) and its constituents: (3R, 4S)-3,4-dimethyloxetan-2-one (1), luteolin (2), stigmasterol (4), 3-O-[6′-O-undecanoyl-β-D-glucopyranosyl]stigmasterol (6), olean-12-en-3-β-O-D-glucopyranoside (7), 3-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosylurs-12-en-28-oic acid (8), 3-O-β-D-glucopyranosyl-(1 → 3)-β-D-glucopyranosyl-27-hydroxyolean-12-ene-28-oic acid (9), methyl…
Botulinum toxin injections into the detrusor
2011
Does low concentration mycotoxin exposure induce toxicity in HepG2 cells through oxidative stress?
2020
The purpose of this study was to determine whether exposure to low concentrations of deoxynivalenol (DON), T-2 toxin (T-2) and patulin (PAT) in a human hepatocellular carcinoma cell line (HepG2) exerts toxic effects through mechanisms related to oxidative stress, and how cells deal with such exposure. Cell viability was determined by the MTT and protein content (PC) assays over 24, 48 and 72 h. The IC
Modeling the effect of ethanol vapor on the germination time of Penicillium chrysogenum.
2005
The influence of ethanol vapor on germination of Penicillium chrysogenum was determined on yeast nitrogen base plus glucose agar medium at 25 degrees C. Ethanol vapors were generated by 0 to 6% (wt/wt) ethanol solutions at the bottom of hermetically closed petri dishes. The logistic equation was used to describe the data as the percentage of germination versus time and to estimate the germination time. The effect of ethanol concentration on germination time was described by a new reparameterized equation, resulting in an estimated limiting ethanol concentration of 4.3%. Up to 3% ethanol, all spores germinated, and the germination time increased with increasing ethanol concentration. At 3.5 …