Search results for "tumorspheres"

showing 2 items of 2 documents

Lung tumorspheres as a drug screening platform against cancer stem cells.

2019

Treatment resistance and metastasis are linked to cancer stem cells (CSCs). This population represents a promising target, but remains unexplored in lung cancer. The main objective of this study was to characterize lung CSCs and discover new therapeutic strategies.

Drugcancer stem cellsLungbusiness.industrymedia_common.quotation_subjectHematologyrespiratory systemrespiratory tract diseasesmedicine.anatomical_structureOncologyCancer stem celllung tumorspheresCancer researchmedicinebusinessdrug screening platformmedia_common
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Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Cancer

2022

Simple Summary Non-small cell lung cancer (NSCLC) is the second most commonly diagnosed cancer and the leading cause of cancer-related death worldwide. Clinical decision-making depends on the histological classification; however, tissue biopsy is frequently not technically feasible due to tumor location or limited tissue samples. Therefore, we propose to find clinical, molecular and histological biomarkers using a minimally invasive approach based on the analysis of the cargo of the blood extracellular vesicles. Exosomes are membranous vesicles present in several biological fluids, which carry biological information to distant tissues, regulating several tumor processes. This study aims to …

squamous cell carcinomaCancer ResearchtumorspheresMICRORNASBIOMARKERSCANCER/TESTIS ANTIGENexosomesNSCLCnon-small cell lung cancer; liquid biopsy; exosomes; extracellular vesicles; cell cultures; adenocarcinoma; squamous cell carcinoma; biomarker; tumorspheresMECHANISMSRNASMICROARRAYIMMUNOTHERAPYCàncernon-small cell lung cancerScience & Technologyadenocarcinomaliquid biopsycell culturesSTATISTICSOncologyPulmonsbiomarkerextracellular vesiclesLife Sciences & Biomedicine
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