Search results for "twin"
showing 10 items of 435 documents
Genetic and Environmental Influence on Structural Strength of Weight-Bearing and Non-Weight-Bearing Bone: A Twin Study
2007
A bivariate genetic analysis among 217 older female twin pairs showed that, although the structural strength of tibia and radius are mainly regulated by same genetic and environmental factors, the tibia is more affected by environment. Introduction: The habitual loading environment of the bone may modulate the relative contribution of genetic and environmental factors to bone structure. The purpose of this study was to estimate the contribution of the common and site-specific genetic and environmental factors to interindividual variation in compressive structural strength of the weight-bearing tibia and non–weight-bearing radius. Materials and Methods: pQCT scans were obtained from both mem…
Intramuscular sex steroid hormones are associated with skeletal muscle strength and power in women with different hormonal status
2015
International audience; Estrogen (E2)-responsive peripheral tissues, such as skeletal muscle, may suffer from hormone deficiency after menopause potentially contributing to the aging of muscle. However, recently E2 was shown to be synthesized by muscle and its systemic and intramuscular hormone levels are unequal. The objective of the study was to examine the association between intramuscular steroid hormones and muscle characteristics in premenopausal women (n = 8) and in postmenopausal monozygotic twin sister pairs (n = 16 co-twins from eight pairs) discordant for the use of E2-based hormone replacement. Isometric skeletal muscle strength was assessed by measuring knee extension strength.…
Kultūrapmaiņas iespaids un “citādība” Vācijas pilsētu pirmajā koplīgumā starp Eizenhūtenštati un Zārluī no 1986 līdz šodienai
2018
Abstrakts: Šajā darbā izmantotā kvalitatīvā analīze apskata Vācijas pirmo veiksmīgi noslēgto starppilsētu sadraudzības līgumu starp Eisenhüttenstadt un Saarlouis pilsētām laika posmā no 1986. gada līdz šodienai. Esošie stereotipi un aizspriedumi, kas vēl joprojām eksistē starp bijušās Rietumvācijas un Austrumvācijas pilsētu iedzīvotājiem, pierāda, ka iepriekš valdošo režīmu atstātās sekas nav zudušas, kas apliecina šī vēsturiski nozīmīgā notikuma analīzes nepieciešamību un aktualitāti. Tēmas aktualitāti pierāda ne tikai esošie aizspriedumi, bet arī neatrisinātie konflikti divu valstu starpā, piemēram Ķīnā un Taivānā vai Indijā un Pakistānā. Darbā apskatītā tēma ilustrē kā valsts apvienošana…
Heritability of refractive astigmatism: a population-based twin study among 63- to 75-year-old female twins.
2013
PURPOSE: To examine the heritability of refractive astigmatism in older women. METHODS: Astigmatism was measured with an autorefractor in 88 monozygotic and 82 dizygotic female twin pairs aged 63 to 75 years. The prevalence and distribution of astigmatism and polar values J0 and J45 were estimated by standard statistical methods. Bivariate maximum likelihood model fitting was used to estimate genetic and environmental variance components using information from both eyes. RESULTS: Mean astigmatism of the more astigmatic eye was 0.93 diopters (D; SD ±0.58). Astigmatism of at least 0.25 D, 0.5 D, 0.75 D, or 1.0 D in either eye was present in 99.7%, 88.5%, 66.5%, and 46.2% of cases, respectivel…
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.
2006
Contains fulltext : 35205.pdf (Publisher’s version ) (Closed access) Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, nor…
Effectiveness of progestogens to improve perinatal outcome in twin pregnancies : an individual participant data meta-analysis
2015
Background In twin pregnancies, the rates of adverse perinatal outcome and subsequent long-term morbidity are substantial, and mainly result from preterm birth (PTB). Objectives To assess the effectiveness of progestogen treatment in the prevention of neonatal morbidity or PTB in twin pregnancies using individual participant data meta-analysis (IPDMA). Search strategy We searched international scientific databases, trial registration websites, and references of identified articles. Selection criteria Randomised clinical trials (RCTs) of 17–hydroxyprogesterone caproate (17Pc) or vaginally administered natural progesterone, compared with placebo or no treatment. Data collection and analysis I…
Longitudinal changes in genetic and environmental influences on older women's walking ability
2009
This study examined the stability and change over time in genetic and environmental influences on walking ability among older women. Maximal walking speed over 10 m and 6-min walking endurance test were measured under standard conditions at baseline and 3 years later. At both times, 63 monozygotic (MZ) and 67 dizygotic (DZ) twin pairs were measured for walking speed and 58 MZ and 56 DZ pairs for walking endurance. Participants were twin sisters reared together and aged 63-75 years at baseline. Genetic and environmental influences were examined using longitudinal genetic modelling. The results showed that walking speed was preserved from baseline to follow-up. Genetic influences on walking s…
Intertwining operators between different Hilbert spaces: connection with frames
2009
In this paper we generalize a strategy recently proposed by the author concerning intertwining operators. In particular we discuss the possibility of extending our previous results in such a way to construct (almost) isospectral self-adjoint operators living in different Hilbert spaces. Many examples are discussed in details. Many of them arise from the theory of frames in Hilbert spaces, others from the so-called g-frames.
Clinically-Driven Virtual Patient Cohorts Generation: An Application to Aorta
2021
The combination of machine learning methods together with computational modeling and simulation of the cardiovascular system brings the possibility of obtaining very valuable information about new therapies or clinical devices through in-silico experiments. However, the application of machine learning methods demands access to large cohorts of patients. As an alternative to medical data acquisition and processing, which often requires some degree of manual intervention, the generation of virtual cohorts made of synthetic patients can be automated. However, the generation of a synthetic sample can still be computationally demanding to guarantee that it is clinically meaningful and that it re…
Security Challenges of IoT-Based Smart Home Appliances
2018
The Internet of Things, IoT, and the related security challenges are reaching homes in the form of smart appliances. If the appliances are compromised, they can be used in botnet attacks against Internet services and potentially cause harm to people and property through the local network, for example, by heating up too much or allowing unauthorized access. The aim of this study was to see how secure these devices are against remote and network attacks. Several devices were tested with attacks coming from the same Wi-Fi network to gain various levels of control of the devices. Their security against a Man-in-the-Middle attack was also studied to see differences in the susceptibility to conne…