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showing 10 items of 10618 documents
Transcriptional Upregulation of Genes Related to Virulence Activation in Entamoeba histolytica
2007
Background To understand the molecular basis of virulence variability in Entamoeba histolytica , this study presents results about differential gene expression induced by E. histolytica trophozoites in liver of hamsters in order to produce experimental amebic liver abscess (ALA) and consequently reactivate its virulence. Methods Amebic cultures were studied before (BALA) and after (AALA) inoculation in hamster peritoneal cavity. Markers of pathogenicity such as the rate of erythrophagocytosis, hemolytic activity, and cytotoxic effects on MDCK cell monolayers were evaluated in order to correlate these phenotypic characteristics to differential gene expression between virulent and non-virulen…
Vibrio vulnificus biotype 2, pathogenic for eels, is also an opportunistic pathogen for humans
1996
We report that the eel pathogen Vibrio vulnificus biotype 2 is also an opportunistic pathogen for humans. Results from a detailed comparative study using reference strains of both biotypes revealed that the clinical strain ATCC 33817, originally isolated from a human leg wound and classified as V. vulnificus (no reference on its biotype is noted), belongs to biotype 2 of the species. As a biotype 2 strain, it is negative for indole and pathogenic for eels and mice, harbors two plasmids of high MrS, and belongs to serogroup E, recently proposed as characteristic of biotype 2 strains. In consequence, appropriate measures must be taken by consumers, particularly by those running a health risk,…
Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction
2013
The Visceral Adiposity Index (VAI) has recently proven to be an indicator of adipose distribution and function that indirectly expresses cardiometabolic risk. In addition, VAI has been proposed as a useful tool for early detection of a condition of cardiometabolic risk before it develops into an overt metabolic syndrome. The application of the VAI in particular populations of patients (women with polycystic ovary syndrome, patients with acromegaly, patients with NAFLD/NASH, patients with HCV hepatitis, patients with type 2 diabetes, and general population) has produced interesting results, which have led to the hypothesis that the VAI could be considered a marker of adipose tissue dysfuncti…
Hyaluronic acid treatment outcome on the post-extraction wound healing in patients with poorly controlled type 2 diabetes: A randomized controlled sp…
2020
Background Hyaluronic acid is widely used in the medical field. However, there is a lack of research about its effect on patients with certain risks, such as compromised wound healing commonly found in patients with poorly controlled type 2 diabetes. The aim of this study is to investigate the efficacy of hyaluronic acid on the post-extraction wound healing and pain in patients with poorly controlled type 2 diabetes. Material and Methods The randomized controlled split-mouth study was designed, which included 30 patients with poorly controlled type 2 diabetes with a bilaterally same teeth in the lower jaw for extraction. The sockets treated with 0.8% hyaluronic acid represented the study gr…
Involvement of the visual evoked potentials in type 2 diabetes
2013
Objective :To assess the function of the optic pathway in type 2 diabetics without retinopathy (40 subjects) or with mild Non Proliferative Diabetic Retinopathy (40 subjects). Methods: VEPs , elicited by means of pattern-reversal stimulation, were studied in a group of 80 non-insulin-dependent diabetics . Results: In subjects suffering from diabetes for less than 10 years, with mild retinopathy or without retinopathy, the amplitude N75-P100 decreased, and this is statistically significant with stimulation at 15’. As the time from disease onset increases, VEP latency (P100) shows a greater increase with the use of small checks (15’), than with large checks (30’) and this becomes statisticall…
Visual Field defects, type A personality,anxiety and coping style in patients with primary open angle glaucoma.
2012
Classification of glaucomatous visual field defects for different severity levels is important. The reasons for this are numerous, and include: to distinguish between healthy and diseased individuals, to have homogeneous grouping criteria when perimetry is used to define the severity of glaucoma, to adjust therapy on the basis of disease severity, to describe visual field conditions in a short and simple format, to monitor the progression of the disease, and to provide a common language for both clinical and research purposes. Many severity classification methods have been proposed, although none have had widespread use in clinical practice. Other methods, like the cumulative defect curve (…
Visual dynamic environment for distributed systems
2002
Algorithms, based on information fusion, are often embodied in visual perception systems. Distributed architectures have been recently proposed to perform integrated computation. The complexity of distributed systems regards both their design, and the software environment to develop applications. Visual and iconic programming style intends to provide expressive tools to implement, to debug, and to execute programs in distributed environment. Multi-layers graphs languages seem suitable to handle such complexity. This paper describes the design of a visual dynamic environment (VDE), which is based on a graph-grammar. A new class of dynamic visual interfaces is also introduced, and its propert…
Fillets:Cues for connections in Focus+Context views of graph-like diagrams
2003
We apply fillets-smoothing of sharp angles at the joints-between the connections and nodes of graph-like diagrams. In situations where the graph layout is constrained, e.g. Focus+Context views or views where the coordinates of the nodes are informative, fillets can clarify the relationships considerably without altering the layout. A visual search experiment supports our hypothesis that with fillets it is considerably easier to perceive node-connection structures. We discuss algorithms with different tradeoffs for flexibility and performance for rendering these connections in a single pass using OpenGL.
Evaluation of the long-term treatment effects of idursulfase using statistical modelling: Data from the Hunter Outcome Survey (HOS)
2019
Treatment for mucopolysaccharidosis type II (MPS II Hunter syndrome) is available in the form of intravenous enzyme replacement therapy (ERT) with idursulfase (Shire, Lexington, MA, USA). This analysis used statistical modelling to evaluate the long-term treatment effects of idursulfase on selected clinical parameters based on data from HOS, a global, observational registry (Shire, Lexington, MA, USA). Mixed modelling was used to analyse data from male patients followed prospectively in HOS who had received idursulfase for 5-8 years and information available for two or more timepoints, of which one was pre-ERT. Data were excluded from patients with only pre-ERT information available, who ha…
Investigation on a MMACHC mutant from cblC disease: The c.394C>T variant
2022
The cblC disease is an inborn disorder of the vitamin B12 (cobalamin, Cbl) metabolism characterized by methylmalonic aciduria and homocystinuria. The clinical consequences of this disease are devastating and, even when early treated with current therapies, the affected children manifest symptoms involving vision, growth, and learning. The illness is caused by mutations in the gene codifying for MMACHC, a 282aa protein that transports and transforms the different Cbl forms. Here we present data on the structural properties of the truncated protein p.R132X resulting from the c.394C > T mutation that, along with c.271dupA and c.331C > T, is among the most common mutations in cblC. Althou…