Search results for "type"

Effect of the IL28B Rs12979860 C/T polymorphism on the incidence and features of active cytomegalovirus infection in allogeneic stem cell transplant …

2013

The current study was aimed at investigating whether the single nucleotide polymorphism (SNP) (rs12979860), upstream of the IL28B gene, had any effect on the incidence rate and the features of active CMV infection in the Allogeneic stem cell transplantation setting. This was a retrospective observational study including 151 patients undergoing T cell-replete Allo-SCT. Donor and recipient IL28 SNP genotype was determined by allele-specific real-time PCR. The incidence rate of active CMV infection was not significantly associated with either the donor or the recipient IL28B SNP genotype. Nevertheless, a trend towards a lower incidence of active CMV infection was noted in the donor T/T populat…

An adaption mechanism for the error threshold of XCSF

2020

Learning Classifier System (LCS) is a class of rule-based learning algorithms, which combine reinforcement learning (RL) and genetic algorithm (GA) techniques to evolve a population of classifiers. The most prominent example is XCS, for which many variants have been proposed in the past, including XCSF for function approximation. Although XCSF is a promising candidate for supporting autonomy in computing systems, it still must undergo parameter optimization prior to deployment. However, in case the later deployment environment is unknown, a-priori parameter optimization is not possible, raising the need for XCSF to automatically determine suitable parameter values at run-time. One of the mo…

Ancient mitochondrial DNA analyses of Iberian sturgeons

2009

Summary Today’s European sturgeons are relics of erstwhile widely distributed populations, diminished mainly by overfishing and habitat changes over the centuries. While extinct European populations in the Baltic and North seas have been identified as Acipenser oxyrhinchus or A. sturio, a clear species determination on the Iberian Peninsula is still lacking. Plans to conserve existing populations and to re-introduce extinct wild populations in European rivers will benefit from information of historic population/genotype composition. In this study, we used techniques involving ancient DNA as well as morphological comparisons based on bony scutes to identify twelve samples from five archaeolo…

Population and Query Interface for a Content-Based Video Database

2002

In this paper we describe the first full implementation of a content-based indexing and retrieval system for MPEG-2 and MPEG-4 videos. We consider a video as a collection of spatiotemporal segments called video objects; each video object is a sequence of video object planes. A set of representative video object planes is used to index each video object. During the database population, the operator, using a semi-automatic outlining tool we developed, manually selects video objects and insert some semantical information. Low-level visual features like color, texture, motion and geometry are automatically computed. The system has been implemented on a commercial relational DBMS and is based on…

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

2013

At mucosal surfaces, the immune system should not initiate inflammatory immune responses to the plethora of antigens constantly present in the environment, but should remain poised to unleash a potent assault on intestinal pathogens. The transcriptional programs and regulatory factors required for immune cells to switch from homeostatic (often tissue-protective) function to potent antimicrobial immunity are poorly defined. Mucosal retinoic-acid-receptor-related orphan receptor-γt-positive (RORγt(+)) innate lymphoid cells (ILCs) are emerging as an important innate lymphocyte population required for immunity to intestinal infections. Various subsets of RORγt(+) ILCs have been described but th…

2014

Pandemic and seasonal influenza viruses cause considerable morbidity and mortality in the general human population. Protection from severe disease may result from vaccines that activate antigen-presenting DC for effective stimulation of influenza-specific memory T cells. Special attention is paid to vaccine-induced CD8+ T-cell responses, because they are mainly directed against conserved internal influenza proteins thereby presumably mediating cross-protection against circulating seasonal as well as emerging pandemic virus strains. Our study showed that influenza whole virus vaccines of major seasonal A and B strains activated DC more efficiently than those of pandemic swine-origin H1N1 and…

La inteligencia de los niños

2005

Partial results of an investigation are presented whose primary objective is to adapt and to standardize the neurocognitive assessment battery C.A.S. of Das and Naglieri (1997) in a child sample. The test is an operationalization of a non traditional intelligence model (PASS) that considers the intelligent behaviors as a group of four cognitive basic processes (planning, attention, simultaneous and successive processing). The objectives of this work are to obtain the psychometric properties of the instrument and also, to analyze if differences exist according to sex and age. The study type is crosswise - transactional. It was administered the CAS to 150 children residents in Buenos Aires am…

219 Incidence Testing of Hunter Syndrome in A Population at Risk - First Results of A Binational Screening Programme

2012

Background Hunter syndrome (Mucopolysaccharidosis type II; X-linked inheritance; prevalence rate in Europe approximately 1:77000 male newborns) is a rare, progressive, multisystemic disease, caused by deficiency of the lysosomal enzyme Iduronate-2-sulfatase. Due to the very heterogeneous phenotype Hunter syndrome is often not diagnosed before pre-school age. This is unfortunate, because patients would significantly benefit from the earliest possible start of treatment containing enzyme replacement therapy. Early screening methods are possible, but due to the rarity of this disease they are too expensive to be performed in all newborns. An at-risk patient population screening provides opport…

Analysis of radionuclide concentration in air released through the stack of a radiopharmaceutical production facility based on a medical cyclotron

2015

Abstract Positron emitting radionuclides are increasingly used in medical diagnostics and the number of radiopharmaceutical production facilities have been estimated to be growing worldwide. During the process of production and/or patient administration of radiopharmaceuticals, an amount of these radionuclides might become airborne and escape into the environment. Therefore, the analysis of radionuclide concentration in the air released to the stack is a very important issue to evaluate the dose to the population living around the plant. To this end, sampling and measurement of radionuclide concentration in air released through the stack of a Nuclear Medicine Center (NMC), provided with a c…

A Population-Based Approach to the Resource-Constrained Project Scheduling Problem

2004

We present a population-based approach to the RCPSP. The procedure has two phases. The first phase handles the initial construction of a population of schedules and these are then evolved until high quality solutions are obtained. The evolution of the population is driven by the alternative application of an efficient improving procedure for locally improving the use of resources, and a mechanism for combining schedules that blends scatter search and path relinking characteristics. The objective of the second phase is to explore in depth those vicinities near the high quality schedules. Computational experiments on the standard j120 set, generated using ProGen, show that our algorithm produ…