Search results for "tyyli"

showing 10 items of 168 documents

Negatively Charged Gangliosides Promote Membrane Association of Amphipathic Neurotransmitters

2018

Lipophilic neurotransmitters (NTs) such as dopamine are chemical messengers enabling neurotransmission by adhering onto the extracellular surface of the post-synaptic membrane in a synapse, followed by binding to their receptors. Previous studies have shown that the strength of the NT-membrane association is dependent on the lipid composition of the membrane. Negatively charged lipids such as phosphatidylserine, phosphatidylglycerol, and phosphatidic acid have been indicated to promote NT-membrane binding, however these anionic lipids reside almost exclusively in the intracellular leaflet of the post-synaptic membrane instead of the extracellular leaflet facing the synaptic cleft. Meanwhile…

0301 basic medicineMOLECULAR-DYNAMICS SIMULATIONSBIOMOLECULAR SYSTEMSkolesteroliasetyylikoliiniSynaptic TransmissionsolukalvotCell membranechemistry.chemical_compoundSCHIZOPHRENIAmolekyylidynamiikkamolecular dynamics (MD)neurotransmissionvälittäjäaineetChemistryLIPID-MEMBRANESGeneral NeurosciencePhosphatidylserineALZHEIMERS-DISEASEMembranemedicine.anatomical_structureHAMILTONIAN REPLICA EXCHANGElipids (amino acids peptides and proteins)dopamineIntracellularneurotransmittermonosialotetrahexosylganglioside (GM1)Synaptic cleftG(M1) GangliosideMolecular Dynamics SimulationNeurotransmission03 medical and health sciencesExtracellularmedicineAnimalsmonosialotetrahexosylgangliosidebinding free energyPhosphatidylglyceroldopamiiniBinding SitesCell Membranehistamiini3112 Neurosciencesta1182cholesterolBILAYERhistamineacetylcholinehermosolut030104 developmental biologyFORCE-FIELDBiophysicssynapsit
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Sourcing on the internet: Examining the relations among different phases of online inquiry

2021

This study examined students’ engagement in sourcing throughout online inquiry, that is, when they specified the information need, formulated search queries, evaluated online texts, and composed a written product. Participants were 167 upper secondary school students. Students completed an online inquiry task in a restricted online environment that utilized authentic online texts. Students’ prior topic knowledge and reading fluency was measured and controlled for in the analysis. The results showed that students engaged in sourcing even in the earliest phases of online inquiry. A sequential regression analysis indicated that the more frequently students engaged in sourcing in specifying the…

21st century abilitiesihmisen ja tietokoneen vuorovaikutusmedia_common.quotation_subjectHuman-computer interfacelähdekritiikkiInformation needsSecondary educationTheory and practice of educationTask (project management)FluencylukiolaisetinformaatiolukutaitoReading (process)secondary educationCredibilityComputingMilieux_COMPUTERSANDEDUCATIONMathematics educationLearning0501 psychology and cognitive sciencesinformation literacyProduct (category theory)verkkoaineistoLB5-3640media_commonDigital literacyoppimistyylitbusiness.industry4. Education05 social sciences050301 educationQA75.5-76.95General MedicineLärandehuman-computer interfaceteaching/learning strategiesElectronic computers. Computer science516 Educational sciencesThe InternetbusinessPsychology0503 educationInformation literacyTeaching/learning strategies 21st century abilities050104 developmental & child psychologyComputers and Education Open
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Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial : Planned 10-Year Follow-up

2022

Abstract The CAPP2 trial investigated the long-term effects of aspirin and resistant starch on cancer incidence in patients with Lynch syndrome (LS). Participants with LS were randomized double-blind to 30 g resistant starch (RS) daily or placebo for up to 4 years. We present long-term cancer outcomes based on the planned 10-year follow-up from recruitment, supplemented by National Cancer Registry data to 20 years in England, Wales, and Finland. Overall, 463 participants received RS and 455 participants received placebo. After up to 20 years follow-up, there was no difference in colorectal cancer incidence (n = 52 diagnosed with colorectal cancer among those randomized to RS against n = 53…

Cancer ResearchLIVER3122 CancerstärkkelysCOLORECTAL-CANCERBUTYRATESDG 3 - Good Health and Well-beingasetyylisalisyylihappoHumansLynchin oireyhtymäpaksusuolisyöpäRISKIncidenceCOLON-CANCERResistant StarchColorectal Neoplasms/drug therapyCONSUMPTIONColorectal Neoplasms Hereditary NonpolyposisASPIRINMICROBIOMEOncologyAspirin/therapeutic useCELLSDIETARY FIBER INTAKE/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingsyöpätauditennaltaehkäisyseurantatutkimusColorectal Neoplasms Hereditary Nonpolyposis/complicationsColorectal NeoplasmsilmaantuvuusFollow-Up Studies
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"Meidän vanhojen vanhuus on tämän ajan rikkautta" : vastarintaiset vanhuuskuvat ja myöhäinen tyyli Eeva Kilven teoksen Kuolinsiivous sisäisessä ja ul…

2015

Tutkielman tavoitteena on tutkia, kuinka Eeva Kilven teos Kuolinsiivous osallistuu julkiseen keskusteluun vanhuudesta ja millaista vanhuuskuvaa se rakentaa, sekä Eeva Kilven myöhäistä tyyliä eli hänen ikänsä ja lähestyvän kuolemansa vaikutusta teokseen. Kysymykseen Kuolinsiivouksen vanhuuskuvasta liittyy oletus teoksen asettumisesta vastarintaan medialle tyypillisiä vanhuuden kurjuutta ja koomisuutta korostavia puhe- ja kuvaamistapoja vastaan. Sekä vastarintaisuuden oletus, että kuoleman voimakas läsnäolo teoksessa ja teoksen sirpaleinen rakenne synnyttävät oletuksen myös teoksesta myöhäisen tyylin (late style) edustajana. Keskeisiksi teorioiksi valikoituvat kulttuuriteoria (Fornäs 1998) ja…

Eeva KilpipäiväkirjavanhuusvastarintaKuolinsiivousvanhuuskuvamyöhäinen tyylilate stylerunous
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Die Erzeugung von Expressivität mithilfe lexikalischer Stilmittel in der Erzählung "Unkenrufe" von G. Grass

1997

Grass Günterkonnotaatiotyyliekspressiivisyyssanastonormi
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Vanhemmuustyylien, vanhemmuuden stressin ja lasten ongelmakäyttäytymisen väliset yhteydet

2010

Lapsuusulospäin suuntautuva ongelmakäyttäytyminenvanhemmuusvanhemmuustyylitvanhemmuuden stressistressisisäänpäin suuntautuva ongelmakäyttäytyminenlapsetkäyttäytymishäiriöt
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Huomioita Juice Leskisen laulujen sanastosta

1998

Leskinen JuicetyylintutkimusiskelmätekstittyyliTiihonen Ilpokielentutkimuksen alueetkielimuodottekstilajitrunotsanaston rikkaus
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Denkstil und Sprache/n in den Wissenschaften. Mit Beispielen aus der Medizin

2011

Scientific research is often understood as an activity or process simultaneously focused on seeking and explaining universal laws of nature. This is especially true in the STEM fields of Science, Technology, Engineering and Math. These universal laws of nature are widely understood as independent from human beings and individual languages. Because of this, the use of English as a lingua franca is often assumed as beneficial for the internationalisation and globalisation of academic life. The use of different languages is more widely accepted in social sciences, humanities and arts because their interest does not focus on universal laws of nature but on societal phenomena. In these disciplin…

Linguistics and Languageajatustyylithought collectivelanguage(s)Political scienceta6121ajatuskollektiivitiedeLanguage and Linguisticskieli/kieletthought styleZeitschrift für angewandte Linguistik
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Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

2020

Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism. The factors that induce these changes remain unknown. Conversely, functional recovery following denervation depends on successful reinnervation. Here, we show that activation of nicotinic acetylcholine receptors (nAChRs) by quantal release of acetylcholine (ACh) from motoneurons is sufficient to prevent changes induced by denervation. Using in vitro assays, ACh and non-hydrolysable ACh analogs repressed the expression of connexin43 and connexin45 hemichannels, which prom…

Male0301 basic medicineCell Membrane PermeabilityNeuromuscular transmissionSkeletal muscleGeneral Physics and AstronomylihaksetasetyylikoliiniReceptors NicotinicConnexinsMembrane PotentialsMice0302 clinical medicineGanglia SpinalMyocytevälittäjäaineetlcsh:ScienceCells CulturedDenervationMultidisciplinaryChemistryQMuscle atrophy3. Good healthCell biologyMuscular AtrophyNicotinic agonistmedicine.anatomical_structuremedicine.symptomAcetylcholinemedicine.drugReinnervationScienceMice TransgenicArticleGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesmedicineAnimalsskeletal muscleMuscle SkeletalAcetylcholine receptorsoluviestintäsomatic systemGeneral ChemistryAcetylcholineMice Inbred C57BLhermosolut030104 developmental biologynervous systemConnexin 43lcsh:Qsense organsSomatic systemlihassurkastumasairaudet030217 neurology & neurosurgeryNature Communications
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Toward a Model of Workforce Training and Development

2019

In the modern, ever-changing world, both employers and employees are struggling in keeping their competitive advantage. Previous studies have recognised that both formal instruction and informal learning are needed to gain and maintain competence. The famous 70-20-10 model states that only 10 per cent of learning occurs during the formal instruction. The challenge for the organisations is how the formal instruction can and should be provided to employees. In this paper, we constructed a model of Workforce Training and Development (WOTRA), based on the current learning theories, modes, methods, and models. WOTRA can be used by both employers and employees to choose an adequate mix of learnin…

Medical educationworkforceoppimistyylittyövoimakoulutustraining and developmentTraining and developmentformal learningkoulutusammatillinen kehitysWorkforceopetusmenetelmättyövoimaBusinesslearning methodsProceedings of the 11th International Conference on Computer Supported Education
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