Search results for "uci"

The 3'-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing …

2003

The expression of the major protein kinase C substrate MARCKS (myristoylated alanine-rich C kinase substrate) is controlled by the stability of its mRNA. While the MARCKS mRNA is long living in quiescent fibroblasts (t1/2 = 14 h), its half-life time is drastically reduced (t1/2 = 2 h) in cells treated with phorbol esters to activate protein kinase C (PKC) or treated with growth factors. In a first step to study the underlying mechanism we identified both a cis-element on the MARCKS mRNA and the corresponding trans-acting factors. Fusing the complete 3'-UTR or specific regions of the 3'-UTR of the MARCKS gene to a luciferase reporter gene caused a drastic decrease in luciferase expression to…

La distribución espacial de hogares perceptores de prestaciones económicas individualizadas: una comparación de casos

2021

El análisis de las desigualdades socioespaciales ha constituido una línea de investigación destacada en el ámbito de las ciencias sociales. No obstante, la cuestión de la desigual proyección territorial de las políticas sociales en el interior de las ciudades ha recibido una menor atención académica. En este artículo se analizan, desde una perspectiva comparada, los patrones de distribución espacial de los hogares perceptores de Prestaciones Económicas Individualizadas (PEI) en dos municipios de la Comunidad Valenciana (España): Bétera y Torrent. Para ello, se implementan distintas técnicas de análisis de puntos espaciales y de Análisis Exploratorio de Datos Espaciales (AEDE). Los resultado…

Cultural experiences in the framework of 'cultural cities': measuring the socioeconomic impact of culture in urban performance

2022

AbstractThis article defines "cultural experience" and places it in a holistic conceptual model; “the cultural city” where it plays a relevant role in improving the performing of cities. The conceptual model combines the basic elements of the heritage city, the smart city and the creative city. The city is interpreted from a threefold perspective; as a repository of resources, as a connective interface, and as the setting for citizens' life and social and professional experiences. In this context, each of these perspectives incorporates culture in a different way, enabling different models of value creation and different processes of production and reproduction of this value. In each of the…

Consistency of Probability Decision Rules and Its Inference in Probability Decision Table

2012

In most synthesis evaluation systems and decision-making systems, data are represented by objects and attributes of objects with a degree of belief. Formally, these data can be abstracted by the form (objects; attributes; P), wherePrepresents a kind degree of belief between objects and attributes, such that,Pis a basic probability assignment. In the paper, we provide a kind of probability information system to describe these data and then employ rough sets theory to extract probability decision rules. By extension of Dempster-Shafer evidence theory, we can get probabilities of antecedents and conclusion of probability decision rules. Furthermore, we analyze the consistency of probability de…

Riesgo, precaución y Constitución

2005

El trabajo analiza los retos que para el Derecho Administrativo plantea la sociedad del riesgo en la que vivimos y cómo las estructuras clásicas de nuestro Estado de Derecho deben adaptarse para hacer frente a los mismos. La revisión de los instrumentos normativos, del papel garante del Estado, la introducción de nuevos instrumentos ambientales de gestión del riesgo como el principio de precaución y toda su proyección son algunas de las soluciones propuestas. The paper analyzes the challenges to Administrative Law posed by the risk society in which we live and how the classic structures of our State of Law must adapt to deal with them. The revision of the normative instruments, the guaranto…

Synthetic vaccines consisting of tumor-associated MUC1 glycopeptide antigens and a T-cell epitope for the induction of a highly specific humoral immu…

2008

Synthetic vaccines consisting of tumor-associated MUC1 glycopeptide antigens and bovine serum albumin.

2005

Revolucionāras mārketinga stratēģijas realizācijas iespēju analīze Latvijas tirgū zīmola pozicionēšanas kontekstā.

2020

Maģistra darba “Revolucionāras mārketinga stratēģijas realizācijas iespēju analīze Latvijas tirgū zīmola pozicionēšanas kontekstā” aktualitāte izriet no problēmas, ka Latvijā ir nepieciešams paaugstināt produktivitāti, ko ir iespējams veikt attīstot inovācijas caur uzņēmējdarbību. Darba mērķis ir, pamatojoties uz teorētisko aspektu analīzi, uzņēmumu pārstāvju un patērētāju aptaujas rezultātiem, izpētīt un izanalizēt Latvijas uzņēmumu revolucionāro mārketinga stratēģiju realizācijas iespējas, kā arī izvirzīt priekšlikumus to īstenošanai Latvijas tirgū zīmolu pozicionēšanas pilnveidošanai. Darba rezultātos tiek noskaidrots, ka Latvi…

A symmetry adapted approach to the dynamic Jahn-Teller problem: Application to mixed-valence polyoxometalate clusters with keggin structure

2012

In this article, we present a symmetry-adapted approach aimed to the accurate solution of the dynamic vibronic problem in large scale Jahn-Teller (JT) systems. The algorithm for the solution of the eigen-problem takes full advantage of the point symmetry arguments. The system under consideration is supposed to consist of a set of electronic levels mixed by the active JT and pseudo JT vibrational modes. Applying the successive coupling of the bosonic creation operators, we introduce the irreducible tensors that are called multivibronic operators. Action of the irreducible multivibronic operators on the vacuum state creates the vibrational symmetry adapted basis that is subjected to the Gram-…

Single-Ion Magnetic Behavior in CoII-CoIII Mixed-Valence Dinuclear and Pseudodinuclear Complexes

2017

Two CoII–CoIII mixed-valence complexes of molecularformulas [Co2(H2L)2(H2O)2][Co2(H2L)2(H2O)(m-phth)]·8(H2O) {1;H2L2–= 2-[(2-hydroxy-3-methoxybenzylidene)amino]-2-(hydroxymethyl)propane-1,3-diolato, m-phth = 1,3-benzene-dicarboxylate} and [Co4(H2L)4(H2O)2(ppda)]·2(dmf)·3.2(H2O) {2;ppda = 1,4-phenylenediacrylate; dmf = N,N-dimethyl-formamide} were synthesized and characterized by single-crys-tal X-ray diffraction and magnetic studies at low temperature.The structural determination reveals that 1 is composed of di-nuclear ion pairs, namely, a cationic [Co2(H2L)2(H2O)2]+(1+) andan anionic [Co2(H2L)2(H2O)(m-phth)]–(1–) unit. In each of these ions, the CoIIand CoIIIcenters present distorted octa…