Search results for "uci"
showing 10 items of 5317 documents
Responsabilidad penal de la empresa adquirente: análisis del artículo 130.2 del Código Penal
2022
El legislador español introdujo en 2010 la responsabilidad penal de las personas jurídicas (art. 31 bis del Código Penal), disponiendo que su responsabilidad no se extinguirá en caso de transformación, fusión o escisión, sino que se trasladará a la entidad o entidades en que se transforme, quede fusionada o absorbida, y se extenderá a la entidad o entidades que resulten de la escisión; dispone, asimismo, que tampoco extingue la responsabilidad penal la “disolución encubierta o meramente aparente” (art. 130.2 CP). En consecuencia, bajo el actual régimen de RPPJ, la empresa adquirente puede resultar responsable, cuando concurren ciertos presupuestos y requisitos, de los delitos de los que era…
Poczucie samotności u kobiet i mężczyzn singli z perspektywy spotkania
2020
Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma.
2006
It is well established that cancer arises in chronically inflamed tissue, and this is particularly notable in the gastrointestinal tract. Classic examples include Helicobacter pylori-associated gastric cancer, hepatocellular carcinoma, and inflammatory bowel disease-associated colorectal cancer. Growing evidence suggests that these associations might be not casual findings. Focusing on individual cytokines has generated evidence that anti-inflammatory cytokine interleukin (IL)-10 and transforming growth factor-beta1 (TGF-beta1) may have a complex role in gastrointestinal carcinogenesis. As an example, IL-10-deficient mice develop severe atrophic gastritis and a chronic enterocolitis, develo…
Video display terminal use and dry eye: preventive measures and future perspectives
2022
Background: Dry eye disease (DED) is a common cause of ocular pain and discomfort. Dry eye disease (DED) stems from a loss-of-tear film homeostasis and is frequently seen in video display terminal (VDT) users. Video display terminal (VDT) use reduces blink rates and increases incomplete blinks, leading to tear film instability and ocular inflammation, promoting DED. Purpose: To assess and evaluate the methods for preventing VDT-associated DED and ocular discomfort. Methods: Studies were found using PubMed and Embase with the search terms: (digital visual terminal* OR computer use OR screen use OR smartphone OR display OR visual display terminal* OR computer vision syndrome OR tablet OR phon…
Light-dependent CK2-mediated phosphorylation of centrins regulates complex formation with visual G-protein.
2008
AbstractCentrins are Ca2+-binding EF-hand proteins. All four known centrin isoforms are expressed in the ciliary apparatus of photoreceptor cells. Cen1p and Cen2p bind to the visual G-protein transducin in a strictly Ca2+-dependent way, which is thought to regulate light driven movements of transducin between photoreceptor cell compartments. These relatively slow motile processes represent a novel paradigm in light adaptation of photoreceptor cells.Here we validated specific phosphorylation as a novel regulator of centrins in photoreceptors. Centrins were differentially phosphorylated during photoreceptor dark adaptation. Inhibitor treatments revealed protein kinase CK2 as the major protein…
Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors.
1999
The assembly of signalling molecules into macromolecular complexes (transducisomes) provides specificity, sensitivity and speed in intracellular signalling pathways. Rod photoreceptors in the eye contain an unusual set of glutamic-acid-rich proteins (GARPs) of unknown function. GARPs exist as two soluble forms, GARP1 and GARP2, and as a large cytoplasmic domain (GARP' part) of the beta-subunit of the cyclic GMP-gated channel. Here we identify GARPs as multivalent proteins that interact with the key players of cGMP signalling, phosphodiesterase and guanylate cyclase, and with a retina-specific ATP-binding cassette transporter (ABCR), through four, short, repetitive sequences. In electron mic…
Mesoporous silica microparticles gated with a bulky azo derivative for the controlled release of dyes/drugs in colon.
2018
[EN] Mesoporous silica microparticles were prepared, loaded with the dye safranin O (M-Saf) or with the drug budesonide (M-Bud) and capped by the grafting of a bulky azo derivative. Cargo release from M-Saf at different pH values (mimicking those found in the gastrointestinal tract) in the absence or presence of sodium dithionite (a reducing agent mimicking azoreductase enzyme present in the colon) was tested. Negligible safranin O release was observed at pH 6.8 and 4.5, whereas a moderate delivery at pH 1.2 was noted and attributed to the hydrolysis of the urea bond that linked the azo derivative onto the external surface of the inorganic scaffold. Moreover, a marked release was observed w…
The functional significance of colour polymorphism in the European common wall lizard (Podarcis muralis)
2021
Colour polymorphisms, the coexistence of two or more colour morphs of a species within a population, have long fascinated evolutionary biologists interested in the mechanisms generating and maintaining phenotypic variation in nature. The functional significance of colour polymorphisms (i.e. their adaptive value) is often linked to the selective mechanisms responsible for their maintenance over time. In lizards, the hypothesis that colour morphs may reflect alternative reproductive strategies involving differential sociosexual behaviour and/or alternative reproductive strategies has come to dominate the field. Wall lizards (family Lacertidae, genus Podarcis), with several geographically dist…
Genome diversity in Torulaspora microellipsoides and its contributions to the evolution os the Saccharomyces genus
2018
En esta tesis presentamos la diversidad genómica y la implicación en diferentes transferencias horizontales de genes de la especie T. microellipsoides. Hipotetizamos que esta especie es la responsable de la transferencia tanto de amplias regiones subtelomericas (hasta 65kb) como de genes individuales a las especies del género Saccharomyces. Hemos descubierto que dos genes que codifican para dos transportadores, uno de fructosa de alta afinidad, FSY1 y otro de transporte al exterior celular de amonio, ATO3, han sido transferidos desde esta especie a algunas Saccharomyces. Por otro lado, la secuenciación del genoma de las cepas disponibles de T. microellipsoides ha revelado la existencia de d…
Evolutionary systems biology of the Mycobacterium tuberculosis complex
2019
Tesis doctoral, 214 páginas