Search results for "uci"

Recurrence quantification analysis as a tool for complex fractionated atrial electrogram discrimination

2012

International audience; Atrial fibrillation is the most encountered pathology of the heart rate. The reasons of its occurrence and its particular characteristics remain unknown, resulting from complex phenomena interaction. From these interactions emerges Complex Fractionated Atrial Electrograms (CFAE) which are useful for the ablation procedure. This study presents a method based on nonlinear data analysis, the Recurrence Quantification Analysis (RQA) applied on intracardiac atrial electrograms to detect CFAE particularities. The results obtained on areas previously tagged by a cardilogist show a good sensitivity to CFAE. Combination of RQA features offers a larger discrimination potential…

MUCI, glycans and the cell-surface barrier to embryo implantation

2001

As it approaches the maternal surface, the attaching embryo encounters the epithelial glycocalyx, which contains the mucin, MUC1. A high density of MUC1 at the cell surface can inhibit cell adhesion. This raises the possibility of the existence of a uterine barrier to implantation that might allow maternal rejection of poorer quality embryos. To investigate the mechanism of implantation, human embryos were incubated with endometrial epithelial monolayers. Hatched blastocysts were found to attach readily to the epithelial surface. MUC1 was lost from epithelial cells beneath and near to the attached embryo, while normal expression persisted in neighbouring cells.

Activation and torque deficits in ACL-reconstructed patients 4 months post-operative

2001

This study compares knee extension and flexion torques and electromyographic (EMG) activity of normal and anterior cruciate ligament (ACL)-reconstructed knees during maximal unilateral isometric and isokinetic tests performed 4–5 months after ACL reconstruction. The subjects consisted of 3 age- and activity-matched groups of 6 subjects: a healthy control group (Ctrl) and 2 groups of patients, with Kenneth-Jones technique using autologous patellar-ligament graft (KJ group) and autologous graft from the semitendinosus tendon (ST group). When compared to the Ctrl group values, each patient group had significant bilateral extension torque deficits in isometric and at slow velocity concentric co…

Posterior Approach to Axis Instability

2016

Many pathologies can cause instability of the cranio-vertebral junction (CVJ). Among the most common diseases must be considered thraumatisms, neoplasms, inflammation, but also congenital malformations. Instability of the CVJ is a potentially life-threatening condition and improper treatment can lead to severe neurological deficits as well as continuous, excruciating pain in the neck. Conservative treatments are often disappointing and surgery must always be taken in consideration when approaching instability of the CVJ, being in many cases the only therapy that can provide satisfactory results.

French version of the Stroke Riskometer™ App: A new tool to reduce the burden of stroke.

2017

G.P.5.10 Novel FHL1 mutation in familial mixed reducing body myopathy with rigid spine

2009

Self‐management of immunomodulatory drug treatment in multiple myeloma patients

2019

Objective Immunomodulatory drugs (IMIDs: thalidomide, lenalidomide and pomalidomide) are widely used in patients with multiple myeloma (MM). The aim of our study was to validate a questionnaire to evaluate the self-capacity of MM patients to manage IMID treatment including side effects. Methods We used a method adapted from the recommendations of the European Organisation for Research and Treatment of Cancer (EORTC) to validate a French questionnaire for patients with MM treated with IMIDs. Results The face validity was evaluated in 15 patients and the construct validity in 56 patients. For discriminant validity, two groups were constituted by gender and depending on whether they had a prev…

Indications and limitations of perineal ultrasound examination.

2010

To The Editor: Perineal or perianal ultrasound (PNUS) is an effective, inexpensive, easily available and not painful but as of now rarely applied diagnostic tool important in the hands of gastroent...

Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-labe…

2013

Summary Background Patients with advanced gastric cancer have a poor prognosis and few efficacious treatment options. We aimed to assess the addition of cetuximab to capecitabine-cisplatin chemotherapy in patients with advanced gastric or gastro-oesophageal junction cancer. Methods In our open-label, randomised phase 3 trial (EXPAND), we enrolled adults aged 18 years or older with histologically confirmed locally advanced unresectable (M0) or metastatic (M1) adenocarcinoma of the stomach or gastro-oesophageal junction. We enrolled patients at 164 sites (teaching hospitals and clinics) in 25 countries, and randomly assigned eligible participants (1:1) to receive first-line chemotherapy with …

Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies

2022

Globally, 2.2 billion people live with some form of vision impairment and/or eye disease. To date, most systematic reviews examining associations have focused on a single eye disease and there is no systematic evaluation of the relationships between eye diseases and diverse physical and mental health outcomes. Moreover, the strength and reliability of the literature is unclear. We performed an umbrella review of observational studies with meta analyses for any physical and/or mental comorbidities associated with eye disease. For each association, random-effects summary effect size, heterogeneity, small-study effect, excess significance bias and 95% prediction intervals were calculated, and …