Search results for "undetermined"
showing 10 items of 32 documents
Optimum Solution for Sliding Formwork Equipment
2015
In the present context of the construction domain where everything needs to respond to the market requirements and time efficiency is an ongoing issue, the paper analyses the optimum solution for a sliding formwork. By using all the previous data obtained through PLM (Product Lifecycle Management) approach, we determined the particular solution. For this creative methods were used.As a future step, by having such solution we can design an intelligent equipment and make a step ahead in the formwork industry.
Mode superposition methods in dynamic analysis of classically and non-classically damped linear systems
1986
Mode-superposition analysis is an efficient tool for the evaluation of the response of linear systems subjected to dynamic agencies. Two well-known mode-superposition methods are available in the literature, the mode-displacement method and the mode-acceleration method. Within this frame a method is proposed called a dynamic correction method which evaluates the structural response as the sum of a pseudostatic response, which is the particular solution of the differential equations, and a dynamic correction evaluated using a reduced number of natural modes. The greater accuracy of the proposed method with respect to the other methods is evidenced through extensive numerical tests, for class…
A correction method for the analysis of continuous linear one-dimensional systems under moving loads
2008
A new correction procedure for dynamic analysis of linear, proportionally damped, continuous systems under traveling concentrated loads is proposed; both cases of non-parametric (moving forces) and parametric (moving mass) loads are considered. Improvement in the evaluation of the dynamic response is obtained by separating the contribution of the low-frequency (LF) modes from that of the high-frequency (HF) modes. The former is calculated, as usual, by classical modal analysis, while the latter is taken into account using a new series expansion of the corresponding particular solution. The advantage of the suggested method is immediately shown in the calculation of the stress distribution s…
On universality of critical behavior in the focusing nonlinear Schrödinger equation, elliptic umbilic catastrophe and the Tritronquée solution to the…
2008
We argue that the critical behavior near the point of “gradient catastrophe” of the solution to the Cauchy problem for the focusing nonlinear Schrodinger equation \(i\epsilon \varPsi _{t}+\frac{\epsilon^{2}}{2}\varPsi _{xx}+|\varPsi |^{2}\varPsi =0\) , e ≪1, with analytic initial data of the form \(\varPsi (x,0;\epsilon)=A(x)e^{\frac{i}{\epsilon}S(x)}\) is approximately described by a particular solution to the Painleve-I equation.
Correlation between CD117+ myeloma plasma cells and hematopoietic progenitor cells in different categories of patients
2015
Background Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bone marrow (BM) microenvironment. Multiparameter flow cytometry (MFC) allows the simultaneous study of the cPC immunophenotype and alterations involving other cells in BM, but rarely these data are interpreted as connected. One exception to this habit are previous studies about relationship between CD117 cPC positivity and hematopoietic progenitor cell (HPC) distribution in newly diagnosed patients. Thus we were interested in verifying the distribution of BM CD34+ HPCs in heal…
Relationship between Bone Marrow PD-1 and PD-L1 Expression and the Presence of Osteolytic Bone Disease in Multiple Myeloma Patients
2018
Abstract Alterations of the bone marrow (BM) immune-microenvironment characterize the progression of monoclonal gammopathies and the development of osteolytic bone disease in multiple myeloma (MM). MM patients exhibit immune dysfunctions as impaired dendritic, NK and T cells, whereas the onset of MM osteolytic lesions is associated to an increased prevalence of Th17 cells. Recently, the pathophysiological role of the programmed cell death protein 1 (PD-1)/PD-1 ligand (PD-L1) pathway together with an increase of myeloid derived suppressor cells (MDSCs) in the induction of tumor tolerance and immune evasion has been underlined with a therapeutic relevance. However, unclear data on the express…
Discriminating Neutrino See-Saw Models
2001
We consider how well current theories can predict neutrino mass and mixing parameters, and construct a statistical discriminator which allows us to compare different models to each other. As an example we consider see-saw models based on family symmetry, and single right-handed neutrino dominance, and compare them to each other and to the case of neutrino anarchy with random entries in the neutrino Yukawa and Majorana mass matrices. The predictions depend crucially on the range of the undetermined coefficients over which we scan, and we speculate on how future theories might lead to more precise predictions for the coefficients and hence for neutrino observables. Our results indicate how ac…
A correction method for dynamic analysis of linear continuous systems
2005
A method to improve the dynamic response analysis of continuous classically damped linear system is proposed. As in fact usually, following a classical approach, a reduced number of eigenfunctions are accounted for and the response is evaluated by integrating the uncoupled differential equations of motion in modal space, neglecting the contribution of high frequency modes (truncation procedure). Here, starting from the given system, it is proposed to set up two differential equations governing the motion of two new continuous systems: the first one contains only the first m non-zero eigenvalues of the given system and the second one contains the remainder non-zero infinity - m eigenvalues. …
Monoclonal gammopathy of ocular significance (MGOS) – a short survey of corneal manifestations and treatment outcomes
2021
Monoclonal gammopathy of ocular significance (MGOS) is a rare subset of monoclonal gammopathy of clinical significance occurring secondary to plasma cell disorders and causing ocular manifestations. We identified 23 patients with paraproteinemic keratopathy (PPK) in the setting of monoclonal gammopathy of unknown significance (MGUS, 10), smoldering multiple myeloma (SMM, 3) or multiple myeloma (MM, 10). Many of these patients with PPK (11/23) presented decreased vision. All patients with MM and 40% of those with other diagnoses such as SMM and MGUS received systemic therapy with or without autologous stem cell transplantation. Four eyes of four patients were treated by penetrating keratopla…
Monoclonal Gammopathies and the Bone Marrow Microenvironment: From Bench to Bedside and Then Back Again
2023
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by a multistep evolutionary pathway, with an initial phase called monoclonal gammopathy of undetermined significance (MGUS), potentially evolving into the symptomatic disease, often preceded by an intermediate phase called “smoldering” MM (sMM). From a biological point of view, genomic alterations (translocations/deletions/mutations) are already present at the MGUS phase, thus rendering their role in disease evolution questionable. On the other hand, we currently know that changes in the bone marrow microenvironment (TME) could play a key role in MM evolution through a progressive shift towards a pro-inflammatory and…