Search results for "unity"
showing 10 items of 3852 documents
Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production
2010
International audience; BACKGROUND & AIMS: Helicobacter pylori-induced immune responses fail to eradicate the bacterium. Nitric oxide (NO) can kill H pylori. However, translation of inducible NO synthase (iNOS) and NO generation by H pylori-stimulated macrophages is inhibited by the polyamine spermine derived from ornithine decarboxylase (ODC), and is dependent on availability of the iNOS substrate L-arginine (L-Arg). We determined if spermine inhibits iNOS-mediated immunity by reducing L-Arg uptake into macrophages. METHODS: Levels of the inducible cationic amino acid transporter (CAT) 2, ODC, and iNOS were measured in macrophages and H pylori gastritis tissues. L-Arg uptake, iNOS expressi…
Human Sociability in Antonio Montecatini's (1537–99) Commentary on Aristotle's Politics
2021
The present article delves into the history of political philosophy by discussing human sociability in Antonio Montecatini's (1537–99) commentary on Aristotle's Politics. The focus is on a philosophical analysis of three interrelated ideas that Montecatini discusses: (1) Aristotle's dictum that human beings are political animals by nature; (2) naturalness of the household; and (3) the nature and origin of political communities. Montecatini's views are briefly related to those of John Case (ca. 1546–1600), and they are also contextualized within the late medieval commentary tradition on the Politics, but the main aim is to clarify Montecatini's philosophical position and examine the ways in …
Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet.
2001
Background—On the basis of our concept that atherosclerosis has an immunopathological background, we tested whether activation of the innate immune system influences its progression.Methods and Results—Hypercholesterolemic (0.5% wt/wt diet) rabbits received either repeated intravenous injections of endotoxin (Escherichia colilipopolysaccharide 1.25 to 2.5 μg, once per week) or a self-limiting cutaneousStaphylococcus aureusinfection with or without a quinolone antibiotic. Measured laboratory parameters, including LDL and HDL cholesterols, were similar in the different groups of hypercholesterolemic animals. All endotoxin-treated animals developed transient episodes of fever after endotoxin a…
Histopathology of the gut in rheumatic diseases
2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity to non-self-antigens. Various evidence indicates that intestinal inflammation occurs in patients with rheumatic diseases. In many rheumatic diseases intestinal inflammation appears to be linked to dysbiosis and possibly represents the common denominator in the pathogenesis of different rheumatic diseases. The continuative interaction between dysbiosis and the intestinal immune system may lead to the aberrant activation of immune cells that ca…
A methodological protocol for Annex I Habitats monitoring: the contribution of Vegetation science.
2016
The methodological foundations of the recently published Manual for Annex I Habitats monitoring in Italy, edited by the Italian Institute for Environmental Protection and Research (ISPRA) with the scientific support of the Italian Society for Vegetation Science (SISV), are here presented, discussed and related to the most consolidated and acknowledged scientific advances in the field of Vegetation science. The proposed methodologies aim at offering simple, yet effective, protocols and procedures towards a harmonized data collection, by way of standardized and shared technical tools, resulting in comparable evaluations of the conservation status of Annex I Habitats. The methodological framew…
Towards more relevance-oriented data mining research
2008
Data mining (DM) research has successfully developed advanced DM techniques and algorithms over the last few decades, and many organisations have great expectations to take more benefit of their data warehouses in decision making. Currently, the strong focus of most DM-researchers is still only on technology-oriented topics. Commonly the DM research has several stakeholders, the major of which can be divided into internal and external ones each having their own point of view, and which are at least partly conflicting. The most important internal groups of stakeholders are the DM research community and academics in other disciplines. The most important external stakeholder groups are manager…
The Expression of an Immune-Related Phenoloxidase Gene is Modulated in Ciona Intestinalis Ovary, Test Cells, Embryos and Larva
2015
Two distinct Ciona intestinalis phenoloxidases (CinPO1, 2) had previously been cloned and sequenced. The CinPO2 is involved in innate immunity and is expressed by inflammatory hemocytes that populate the tunic and pharynx vessels as a response to LPS inoculation. In situ hybridization and immunohistochemistry assays on histological section, showed that the expression of this gene and the produced protein are shared with oogenesis, embryogenesis and larval morphogenesis. Intriguingly, upregulation of gene transcription was found in the test cell layer that envelopes the ovary follicle, ovulated egg, and gastrula, as well as it was modulated in the zygotic nucleus of outer balstomers of 32-ce…
Analyzing the Correlation of Classical and Community-aware Centrality Measures in Complex Networks
2021
International audience; Identifying influential nodes in social networks is a fundamental issue. Indeed, it has many applications, such as inhibiting epidemic spreading, accelerating information diffusion, preventing terrorist attacks, and much more. Classically, centrality measures quantify the node's importance based on various topological properties of the network, such as Degree and Betweenness. Nonetheless, these measures are agnostic of the community structure, although it is a ubiquitous characteristic encountered in many real-world networks. To overcome this drawback, there is a growing trend to design so-called community-aware centrality measures. Although several works investigate…
Implementation of the chemistry module MECCA (v2.5) in the modal aerosol version of the Community Atmosphere Model component (v3.6.33) of the Communi…
2013
Abstract. A coupled atmospheric chemistry and climate system model was developed using the modal aerosol version of the National Center for Atmospheric Research Community Atmosphere Model (modal-CAM; v3.6.33) and the Max Planck Institute for Chemistry's Module Efficiently Calculating the Chemistry of the Atmosphere (MECCA; v2.5) to provide enhanced resolution of multiphase processes, particularly those involving inorganic halogens, and associated impacts on atmospheric composition and climate. Three Rosenbrock solvers (Ros-2, Ros-3, RODAS-3) were tested in conjunction with the basic load-balancing options available to modal-CAM (1) to establish an optimal configuration of the implicitly-sol…
Temporal variability of airborne bacterial community structure in an urban area
2006
International audience; Temporal airborne bacterial genetic community structure and meteorological factors were analysed above an urban area in the northwest of France from December 2003 to April 2004 with a sampling strategy considering different time intervals (from an hour to a month). Principal component analysis (PCA) of B-ARISA (Bacterial-Automated Ribosomal Intergenic Spacer Analysis) profiles revealed a hierarchy in the temporal variability of bacterial community: daily<weekly<seasonal. Co-inertia analysis between B-ARISA data and meteorological factors demonstrated the correlation between the seasonal variability in the bacterial community and climatic conditions such as temperatur…