Search results for "uno"

Kone ja automaatti: kirjallisia (takaisin)kytkentöjä.

2011

MILKER’S NODULE. A PERPLEXING FARMYARD INFECTION AND THREAT TO THE IMMUNOCOMPROMISED

2017

Milker’s nodules, also called paravaccinia, is a DNA virus transmitted from infected cows to humans. It results from contact with cattle, cattle byproducts, or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers, and agricultural tourists. The viral infection begins 5—15 days after inoculation as an erythematous-purple, round nodule with a clear depressed center, and a surrounding erythematous ring. While familiar to those in farming communities, the presence of the nodule may be concerning to others, particularly the immunosuppressed. Milker’s nodules are selflimited in immunocompetent individuals and heal without scarring within 8 weeks. An…

Modeling the probability distribution of peak discharge for infiltrating hillslopes

2017

Hillslope response plays a fundamental role in the prediction of peak discharge at the basin outlet. The peak discharge for the critical duration of rainfall and its probability distribution are needed for designing urban infrastructure facilities. This study derives the probability distribution, denoted as GABS model, by coupling three models: (1) the Green-Ampt model for computing infiltration, (2) the kinematic wave model for computing discharge hydrograph from the hillslope, and (3) the intensity-duration-frequency (IDF) model for computing design rainfall intensity. The Hortonian mechanism for runoff generation is employed for computing the surface runoff hydrograph. Since the antecede…

Runoff coefficients to predict peak discharge at hillslope scale: A small contribution to theoretical hydrology

2018

The science of hydrology holds a central role in the field of environmental Earth science, being intimately connected to meteorology, climatology, hydrogeology and ecology. In particular, the knowledge of hillslope hydrology is fundamental for understanding the flood phenomenon, for predicting the peak discharge and its probability distribution, which is necessary in many practical applications (design of hydraulic structures, urban, extra-urban planning, etc.). Using different approaches, there have been a multitude of studies on the hydrologic response at hillslope scale. One approach for deriving the hillslope response utilizes, in a distributed form, the differential equations of unstea…

Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective MLH1 Methylation Analysis

2022

Simple Summary International guidelines recommend universal screening of endometrial carcinoma patients for Lynch syndrome, a hereditary cancer predisposition syndrome. Screening is based on mismatch repair protein immunohistochemistry and reflex MLH1 methylation analysis to exclude the likely sporadic cases of MMR deficiency. As sporadic MLH1 protein loss is common in endometrial carcinoma, the ability to target methylation testing would save efforts and costs. We discovered that limiting methylation testing to patients under 65 years would have significantly reduced the testing effort while maintaining a low false negative rate for MLH1-LS detection (0% and 3% in our clinic and registry-b…

Is HLA type a possible cancer risk modifier in Lynch syndrome?

2022

Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have a broad 30-80% risk of developing various malignancies, and more precise, individual risk estimations would be of high clinical value, allowing tailored cancer prevention and surveillance. Due to MMR deficiency, LS cancers are characterized by the accumulation of frameshift mutations leading to highly immunogenic frameshift peptides (FSPs). Thus, immune surveillance is proposed to inhibit the outgrowth of MMR-deficient cell clones. Recent studies have shown that immunoediting during the evolution of MMR-deficient…

In Vitro Cytotoxic Effect of Aqueous Extracts from Leaves and Rhizomes of the Seagrass Posidonia oceanica (L.) Delile on HepG2 Liver Cancer Cells: Fo…

2023

Aqueous extracts from Posidonia oceanica’s green and brown (beached) leaves and rhizomes were prepared, submitted to phenolic compound and proteomic analysis, and examined for their potential cytotoxic effect on HepG2 liver cancer cells in culture. The chosen endpoints related to survival and death were cell viability and locomotory behavior, cell-cycle analysis, apoptosis and autophagy, mitochondrial membrane polarization, and cell redox state. Here, we show that 24 h exposure to both green-leaf- and rhizome-derived extracts decreased tumor cell number in a dose–response manner, with a mean half maximal inhibitory concentration (IC50) estimated at 83 and 11.5 μg of dry extract/mL, respecti…

Latvijas Brīvības cīņu pieminekļu atjaunošana (1987-1998)

2016

Maģistra darbā “Latvijas Brīvības cīņu pieminekļu atjaunošana (1987–1998)” tiek pētīta no 1920. līdz 1940. gadam celto Latvijas Brīvības cīņām veltīto pieminekļu atjaunošana no 1987. līdz 1998. gadam. Šie monumenti pēc Latvijas okupācijas 1940. gadā tika iznīcināti, postīti un bija neapkopti, taču līdz ar trešo Atmodu aizsākās to atkārtotā izveide, remonts, restaurācija un sakopšana. Pētījumā skaidrota šo pieminekļu funkcija, celtniecības mērķis un nozīme sabiedrības vēsturiskās atmiņas veidošanā. Plaši raksturota monumentu atjaunošanas darbu praktiskā norise, īpašu uzmanību veltot aplūkotajā periodā atkārtoti uzstādītajiem 23 padomju režīma gados iznīcinātajiem pieminekļiem. Darba gaitā pa…

Perception of pathogenic or beneficial bacteria and their evasion of host immunity: pattern recognition receptors in the frontline

2015

International audience; Plants are continuously monitoring the presence of microorganisms to establish an adapted response. Plants commonly use pattern recognition receptors (PRRs) to perceive microbe- or pathogen-associated molecular patterns (MAMPs/PAMPs) which are microorganism molecular signatures. Located at the plant plasma membrane, the PRRs are generally receptor-like kinases (RLKs) or receptor-like proteins (RLPs). MAMP detection will lead to the establishment of a plant defense program called MAMP-triggered immunity (MTI). In this review, we overview the RLKs and RLPs that assure early recognition and control of pathogenic or beneficial bacteria. We also highlight the crucial func…

Poesie di Chen Jingrong - Un piccolo omaggio

2010

Chen Jingrong is a woman poet who has strongly influenced the poetry of the contemporary poet Duo Duo. Having lived from 1917 until 1989, her work spans through the whole XX century. The paper presents her work with a special attention on translation problems. It focuses on an analysis of her poetry on the basis of the “translation shift” described by Cosima Bruno. Differently from Bruno, the analysis is made not on two texts, A language and B language texts, but rather on three texts. In this case, the one in Chinese of the original version, the one in English, the language of the first translation, and the one in Italian, the language of the second translation by G. Tamburello.