Search results for "uno"
showing 10 items of 14944 documents
In vivoanalysis of the lumenal binding protein (BiP) reveals multiple functions of its ATPase domain
2007
International audience; The endoplasmic reticulum (ER) chaperone binding protein (BiP) binds exposed hydrophobic regions of misfolded proteins. Cycles of ATP hydrolysis and nucleotide exchange on the ATPase domain were shown to regulate the function of the ligand-binding domain in vitro. Here we show that ATPase mutants of BiP with defective ATP-hydrolysis (T46G) or ATP-binding (G235D) caused permanent association with a model ligand, but also interfered with the production of secretory, but not cytosolic, proteins in vivo. Furthermore, the negative effect of BiP(T46G) on secretory protein synthesis was rescued by increased levels of wild-type BiP, whereas the G235D mutation was dominant. U…
Variation in parasite resistance of Arctic charr, Salvelinus alpinus, between and within sympatric morphs
2021
Abstract Genetic variation in resistance against parasite infections is a predominant feature in host–parasite systems. However, mechanisms maintaining genetic polymorphism in resistance in natural host populations are generally poorly known. We explored whether differences in natural infection pressure between resource‐based morphs of Arctic charr (Salvelinus alpinus) have resulted in differentiation in resistance profiles. We experimentally exposed offspring of two morphs from Lake Þingvallavatn (Iceland), the pelagic planktivorous charr (“murta”) and the large benthivorous charr (“kuðungableikja”), to their common parasite, eye fluke Diplostomum baeri, infecting the eye humor. We found t…
Costs and Benefits of Experimentally Induced Changes in the Allocation of Growth versus Immune Function under Differential Exposure to Ectoparasites
2010
Background Ecological immunology has focused on the costs of investment in immunocompetence. However, understanding optimal resource allocation to immune defence requires also identification of its benefits, which are likely to occur only when parasites are abundant. Methodology We manipulated the abundance of parasitic hen fleas in blue tit (Cyanistes caeruleus) nests, and supplemented their hosts, the nestlings, with methionine (a sulphur amino acid enhancing cell-mediated immunity) during day 3–6. We found a significant interaction between these two experimental factors on the development of immune defences and growth rates. Only in parasitized nests did methionine supplementation boost …
How to escape from insect egg parasitoids : a review of potential factors explaining parasitoid absence across the Insecta
2020
The egg is the first life stage directly exposed to the environment in oviparous animals, including many vertebrates and most arthropods. Eggs are vulnerable and prone to mortality risks. In arthropods, one of the most common egg mortality factors is attack from parasitoids. Yet, parasitoids that attack the egg stage are absent in more than half of all insect (sub)orders. In this review, we explore possible causes explaining why eggs of some insect taxa are not parasitized. Many insect (sub)orders that are not attacked by egg parasitoids lack herbivorous species, with some notable exceptions. Factors we consider to have led to escape from egg parasitism are parental egg care, rapid egg deve…
The Strategic Reference Gene: an organismal theory of inclusive fitness
2019
How to define and use the concept of inclusive fitness is a contentious topic in evolutionary theory. Inclusive fitness can be used to calculate selection on a focal gene, but it is also applied to whole organisms. Individuals are then predicted to appear designed as if to maximise their inclusive fitness, provided that certain conditions are met (formally when interactions between individuals are 'additive'). Here we argue that applying the concept of inclusive fitness to organisms is justified under far broader conditions than previously shown, but only if it is appropriately defined. Specifically, we propose that organisms should maximise the sum of their offspring (including any accrued…
A Systematic Review of the Hydrological, Environmental and Durability Performance of Permeable Pavement Systems
2021
Due to urbanization, large portions of vegetated territory have been replaced by waterproof surfaces. The consequences are greater outflows, lower infiltration, and lower evapotranspiration. Pavement systems made with permeable surfaces allow the infiltration of water, ensuring reduction of runoff volume. In this paper, the methods of analysis of the hydrological and environmental performance of the pavement systems are reviewed in the context of urban drainage and regarding their durability. The purpose is to present an overview of the studies published during the last decade in the field. The Pubmed and Web Science Core Collection electronic databases were used to conduct the scientific l…
The role of urban growth, climate change, and their interplay in altering runoff extremes
2018
Changes in climate and urban growth are the most influential factors affecting hydrological characteristics in urban and extra-urban contexts. The assessment of the impacts of these changes on the extreme rainfall–runoff events may have important implications on urban and extra-urban management policies against severe events, such as floods, and on the design of hydraulic infrastructures. Understanding the effects of the interaction between climate change and urban growth on the generation of runoff extremes is the main aim of this paper. We carried out a synthetic experiment on a river catchment of 64 km2to generate hourly runoff time series under different hypothetical scenarios. We impos…
Flow Control of Fluid in Pipelines Using PID Controller
2019
In this paper, a PID controller is utilized in order to control the flow rate of the heavy oil in pipelines by controlling the vibration in a motor pump. A torsional actuator is placed on the motor pump in order to control the vibration on a motor and consequently controlling the flow rates in pipelines. The necessary conditions for the asymptotic stability of the proposed controller are validated by implementing the Lyapunov stability theorem. The theoretical concepts are validated utilizing numerical simulations and analysis, which proves the effectiveness of the PID controller in the control of flow rates in pipelines.
Construcción de puentes y avenidas fluviales: algunos debates técnicos en el academicismo ilustrado del Reino de Valencia
2020
Con el afianzamiento de las políticas reformistas y la consolidación de las academias de bellas artes, durante el último tercio del siglo XVIII se desarrolló una creciente polémica entre los arquitectos y los maestros de obra en torno a la proyección y diseño de obra civil, particularmente la relacionada con ambientes fluviales. En este artículo se valora, con diferentes ejemplos, la incidencia de este debate en la proyección de puentes y su capacidad de resistencia a las avenidas fluviales. During the last third of the 18th century, reformist policies and the consolidation of the fine arts academies were consolidated. This fact affected the architects and the master builders with a policy …