Search results for "upe"
showing 10 items of 7447 documents
Nitic oxide promotes strong cytotoxicity of phenolic compounds against escherichia coli. The influence of antioxidant defenses
2003
[EN] The induction of mutagenic and cytotoxic effects by simple phenolics, including catechol (CAT), 3,4dihydroxyphenylacetic acid (DOPAC), hydroquinone (HQ), and 2,5-dihydroxyphenylacetic (homogentisic) acid (HGA), appears to occur through an oxidative mechanism based on the ability of these compounds to undergo autoxidation, leading to quinone formation with the production of reactive oxygen species. This is supported by the detection of such adverse effects in plate assays using Escherichia coli tester strains deficient in the OxyR function, but not in OxyR(+) strains. The OxyR protein is a redox-sensitive regulator of genes encoding antioxidant enzymes including catalase and alkyl hydro…
Antioxidant Properties of a Supercritical Fluid Extract of the Halophyte Mesembryanthemum nodiflorum L. from Sicilian Coasts: Nutraceutical and Cosme…
2020
The aim of this paper was to obtain different extracts from the aerial parts of Mesembryanthemum nodiflorum, comparing traditional extraction (using solvents with increasing polarity such as hexane, ethanol 80%, acetone 70% and water) with an eco-friendly technique (supercritical fluid extraction (SFE))
PTEN Mediates the Antioxidant Effect of Resveratrol at Nutritionally Relevant Concentrations
2014
Introduction.Antioxidant properties of resveratrol have been intensively studied for the last years, bothin vivoandin vitro. Its bioavailability after an oral dose is very low and therefore it is very important to make sure that plasma concentrations of free resveratrol are sufficient enough to be active as antioxidant.Aims.In the present study, using nutritionally relevant concentrations of resveratrol, we aim to confirm its antioxidant capacity on reducing peroxide levels and look for the molecular pathway involved in this antioxidant effect.Methods.We used mammary gland tumor cells (MCF-7), which were pretreated with different concentrations of resveratrol for 48 h, and/or a PTEN inhibit…
In vitro bioaccessibility, transepithelial transport and antioxidant activity of Urtica dioica L. phenolic compounds in nettle based food products
2016
Nettle (Urtica dioica L.) is a well-known plant with a wide historical background use of stems, roots and leaves. Nettle leaves are an excellent source of phenolic compounds, principally 3-caffeoylquinic acid (3-CQA), caffeoylmalic acid (CMA) and rutin. The aim of this work was to evaluate the bioaccessibility (BAC), the bioavailability (BAV) and the antioxidant activity of nettle phenolic compounds present in foods and supplements. The BAC of nettle phenolics was evaluated with an in vitro dynamic digestion of real food matrices: the type of food matrix and chemical characteristic affected the kinetics of release and solubilization, with the highest BAC after duodenal digestion. A study of…
Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside
2003
Three flavonoids, gnaphaliin, pinocembrin and tiliroside, isolated from Helichrysum italicum, were studied in vitro for their antioxidant and/or scavenger properties and in vivo in different models of inflammation. In vitro tests included lipid peroxidation in rat liver microsomes, superoxide radical generation in the xanthine/xanthine oxidase system and the reduction of the stable radical 1,1-diphenyl-2-pycryl-hydrazyl (DPPH). Acute inflammation was induced by application of 12-O-tetradecanoylphorbol 13-acetate (TPA) to the mouse ear or by subcutaneous injection of phospholipase A(2) or serotonin in the mouse paw. Eczema provoked on the mouse ear by repeated administration of TPA was selec…
The Inclusion of a Supercritical Fluid Extract, Obtained From Honey Bee Pollen, in the Diet of Gilthead Sea Bream (Sparus aurata), Improves Fish Immu…
2020
In the present study, the immune-stimulatory effect of two levels of honey bee pollen (5 and 10%, P5 and P10 treatment, respectively) and its supercritical fluid extract (0. 5 and 1%, E0.5 and E1, respectively) included in the diet, was tested in gilthead seabream (Sparus aurata). The in vivo trial was preceded by the evaluation of antioxidant properties of three different bee pollen extracts obtained by water, ethanol 80%, and Supercritic Fluids Extraction (SFE). The preliminary evaluation attested that the SFE showed the lowest extraction yield (10.47%) compared to ethanol 80% (48.61%) and water (45.99%). SFE extract showed good antioxidant properties with high polyphenol content (13.06 m…
Efficient transfer of positrons from a buffer-gas-cooled accumulator into an orthogonally oriented superconducting solenoid for antihydrogen studies
2012
Positrons accumulated in a room-temperature buffer-gas-cooled positron accumulator are efficiently transferred into a superconducting solenoid which houses the ATRAP cryogenic Penning trap used in antihydrogen research. The positrons are guided along a 9 m long magnetic guide that connects the central field lines of the 0.15 T field in the positron accumulator to the central magnetic field lines of the superconducting solenoid. Seventy independently controllable electromagnets are required to overcome the fringing field of the large-bore superconducting solenoid. The guide includes both a 15° upward bend and a 105° downward bend to account for the orthogonal orientation of the positron accu…
Entorn de l'origen de la teoria sociocultural: la zona de desenrotllament pròxim en la vida de Vigotsky
2015
Aquest treball presenta la Zona de Desenvolupament Pròxim (ZDP) en la vida de Lev Vigostky, com el punt d'inflexió en l'origen de l'explicació sociocultural sobre l'origen dels processos psicològics superiors. La ZDP té la capacitat d'entendre aquest salt qualitatiu, en la vida d'aquest autor, ja que rescata el context social i cultural com a part la pròpia explicació del desenvolupament personal que, en el cas de Vigostky, discorre des de l'estètica a la Psicologia emprant la dialèctica com a mètode. Per tant, el paper instrumental de la dialèctica, una formació profundament humanística i la necessitat una resposta nova al problema de la consciència en un moment conceptual i polític crític…
Lensless object scanning holography for two-dimensional mirror-like and diffuse reflective objects
2013
Recently proposed lensless object scanning holography (LOSH) [Opt. Express 20, 9382 (2012)] is a fully lensless method capable of improving the image quality in digital Fourier holography applied to one-dimensional (1D) reflective objects and it involves a very simplified experimental setup. LOSH is based on the recording and digital postprocessing of a set of digital lensless Fourier transform holograms, which finally results in a synthetic image with improved resolution, field-of-view (FOV), signal-to-noise ratio (SNR), and depth of field. In this paper, LOSH is extended to the cases of two-dimensional (2D) mirror-like and 1D diffuse-based objects. For 2D mirror-like objects, the experime…
Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice
2013
The role of endocannabinoids such as anandamide during atherogenesis remains largely unknown. Fatty acid amide hydrolase (FAAH) represents the key enzyme in anandamide degradation, and its inhibition is associated with subsequent higher levels of anandamide. Here, we tested whether selective inhibition of FAAH influences the progression of atherosclerosis in mice. Selective inhibition of FAAH using URB597 resulted in significantly increased plasma levels of anandamide compared to control, as assessed by mass spectrometry experiments in mice. Apolipoprotein E-deficient (ApoE(-/-)) mice were fed a high-fat, cholesterol-rich diet to induce atherosclerotic conditions. Simultaneously, mice recei…