Search results for "upe"
showing 10 items of 7447 documents
Rapid identification and sorting of viable virus-reactive CD4+ and CD8+ T cells based on antigen-triggered CD137 expression
2008
Abstract Current methods for the detection and isolation of antigen-specific CD4 + and CD8 + T cells require the availability of peptide/MHC multimers or are restricted to cells that produce cytokines after antigen contact. Here we show that de novo cell surface expression of the TNF-receptor family member CD137 (4-1BB) identifies recently activated, but not resting, human CD4 + and CD8 + memory T cells. Maximum CD137 expression level is uniformly observed in both T-cell subsets at 24h after stimulation with antigen. In experiments with CMV and EBV-reactive T cells, we confirmed the specificity of CD137 expression by co-staining with peptide/HLA tetramers. Substantial proportions of CD137 +…
Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines.
2006
AbstractIn HLA-incompatible hematopoietic stem cell transplantation, alloreactive donor T cells recognizing recipient mismatch HLA cause severe graft-versus-host disease (GVHD). Strategies allowing the selective depletion of alloreactive T cells as well as the enhancement of graft-versus-malignancy immunity would be beneficial. We generated donor CD8 T-cell lines in vitro using allogeneic recipient cells mismatched at a single HLA class I allele or haplotype as stimulators. Recipient cells were obtained from acute myeloid leukemias, renal-cell carcinomas, and CD40L-induced B lymphoblasts. Resulting alloreactive T cells were activated by incubating day 21 T-cell cultures with HLA-mismatch tr…
CARS spectroscopy of CH4 for implication of temperature measurements in supercritical LOX/CH4 combustion
2007
International audience; Experimental and theoretical investigations of coherent anti-Stokes Raman spectroscopy of CH4 have been carried out. Experimental spectra were measured in a heated high-pressure test cell and compared with numerical simulations. Good agreement was obtained for the temperature and the pressure dependence of CARS spectra in the ranges 300-1100 K and 0.1-5.0 MPa. The observed dependencies provide useful guidance for CARS thermometry, allowing quantitative measurements of temperature in high-pressure combustors. Application of multiplex CH4 CARS thermometry for single-shot measurements in a LOX/CH4 combustion at high pressure was demonstrated at supercritical conditions …
ALMA spectral survey of Supernova 1987A – molecular inventory, chemistry, dynamics and explosive nucleosynthesis
2017
We report the first molecular line survey of Supernova 1987A in the millimetre wavelength range. In the ALMA 210--300 and 340--360 GHz spectra, we detected cold (20--170 K) CO, 28SiO, HCO+ and SO, with weaker lines of 29SiO from ejecta. This is the first identification of HCO+ and SO in a young supernova remnant. We find a dip in the J=6--5 and 5--4 SiO line profiles, suggesting that the ejecta morphology is likely elongated. The difference of the CO and SiO line profiles is consistent with hydrodynamic simulations, which show that Rayleigh-Taylor instabilities cause mixing of gas, with heavier elements much more disturbed, making more elongated structure. We obtained isotopologue ratios of…
CULTURE CITIES
2008
Il volume approfondisce le metodologie e le tecnologie per la realizzazione dei distretti culturali. La valorizzazione dei distretti culturali è finalizzata alla creazione di un ambiente favorevole al mantenimento e all’attrazione di attività economiche compatibili e a basso impatto ambientale (e-business) e alla diffusione della conoscenza del territorio e delle sue valenze (e-tourism). Il volume è dunque il risultato di una sperimentazione attiva sul territorio, in cui si elaborano le linee guida per il risanamento delle aree degradate ed il recupero delle cortine storiche dell’area di Piazza Garraffello (l’antico mercato della Vucciria) a Palermo Il volume è il risultato della ricerca CI…
Brevi considerazioni su piogge intense e potenzialità di produzione del deflusso superficiale in Sicilia
2013
Vengono presentati i metodi aggiornati per la stima delle precipitazioni intense massime annue di fissato tempo di ritorno in Sicilia. Dall‟osservazione della distribuzione spaziale dei parametri assunti nei modelli di stima emergono aree a maggior rischio riguardo l‟intensità di pioggia, qui commentate. Il richiamo a recenti studi che riguardano la produzione del deflusso superficiale a scala media annua o a scala di evento, consente di avanzare alcune considerazioni di tipo spaziale, con particolare attenzione all‟area del messinese, su questa importante propensione idrologica notoriamente fonte di dissesto idrogeologico e di pericolo alluvionale. The updated methods for the estimation of…
Dabas vielu ietekme uz peļu uzvedības reakcijām
2014
Elektroniskā versija nesatur pielikumus
Quantifying carbon dioxide flux from dormant volcanoes with low-temperature fumarolic activity: demonstration from measurements at La Soufrière, Guad…
2013
Quantifying the flux of magma derived CO2 dissipated by fumarolic fields at dormant volcanoes is fundamental to assess their current state of hydrothermal activity and, therefore, the likelihood of a future phreatic/magmatic eruption. There is, in fact, documented evidence that gas fluxes, and CO2 flux in particular, can increase substantially during volcanic unrests and prior to eruption, due to either degassing of new ascending magma or changes in the hydrothermal system physical regime. Quantifying CO2 emissions is relatively straightforward at open-conduit volcanoes with high-temperature gas venting, which release high enough quantities of SO2 remotely measurable with UV spectroscopy an…
Search for anomalous production of events with two photons and additional energetic objects at CDF
2010
27 páginas, 17 figuras, 5 tablas.-- CDF Collaboration: et al.
(no title)
1999
We propose hereafter that the signature of the Space-Time metric (+++-) is not anymore frozen at the Planck scale and presents quantum fluctuations (+++±) untill 0 scale where it becomes Euclidean (++++). (i) At the albraic level we suggest an oscillation path (3,1) (4,0) exluding (2,2). We built the quotient topological space describing the superposition of the Lorentzian and the Riemanian metrics. In terms of quantum groups we evidence a relation between q-deformation and deformation of the signature. We have obtained a new algebraic construction ( a new cocycle bicross products by twisting) which allowed us to unify the Lorentzian and the Euclidean signatures within a unique quantum grou…