Search results for "upe"

Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

2021

Cancer theranostics is a new concept of medical approach that attempts to combine in a unique nanoplatform diagnosis, monitoring and therapy so as to provide eradication of a solid tumor in a non-invasive fashion. There are many available solutions to tackle cancer using theranostic agents such as photothermal therapy (PTT) and photodynamic therapy (PDT) under the guidance of imaging techniques (e.g., magnetic resonance—MRI, photoacoustic—PA or computed tomography—CT imaging). Additionally, there are several potential theranostic nanoplatforms able to combine diagnosis and therapy at once, such as gold nanoparticles (GNPs), graphene oxide (GO), superparamagnetic iron oxide nanoparticles (SP…

Analysis of Possible Mechanisms Accounting for Raf-1 Kinase Inhibitor Protein Downregulation in Hepatocellular Carcinoma

2012

Abstract Raf-1 kinase inhibitor protein (RKIP) is a tumor and metastasis suppressor that promotes drug-induced apoptosis in cancer cells. It is frequently downregulated, both at the mRNA and protein level, in hepatocellular carcinoma (HCC), but the mechanisms leading to this reduction are obscure. We sequenced the whole RKIP gene in three human HCC cell lines (HA22T/VGH, HepG2, and Hep3B), and in five clinical HCC samples, but could not find any gene variant that might account for their low RKIP levels. We also examined whether gene methylation may be responsible for the altered RKIP expression. No methylation of the RKIP gene was found in the tumor samples, while among the cell lines only …

Mechanisms of Increased Vascular Superoxide Production in an Experimental Model of Idiopathic Dilated Cardiomyopathy

2005

Objective— In the present study, we sought to identify mechanisms underlying increased oxidative stress in vascular tissue in an experimental animal model of chronic congestive heart failure (CHF). Methods and Results— Superoxide and nitric oxide (NO) was measured in vessels from cardiomyopathic hamsters (CHF hamsters) and golden Syrian hamsters. We also determined expression of endothelial nitric oxide synthase (NOSIII), the soluble guanylyl cyclase, the cGMP-dependent kinase, and the NADPH oxidase. To analyze the contribution of the renin-angiotensin system to oxidative stress, CHF hamsters were treated with the angiotensin-converting enzyme inhibitor captopril for 200 days (120 mg · kg …

Substrat i superstrat en l'evolució del català

1999

Reflections on the significance of substratum and superstratum in the genesis and evolution of Catalan. The author considers how the recourse to the pre-Roman susbtratum in the etymological interpretation or in the historical and critical grammar has been carried to excess both by those absolutely against it and by those who take it as an all-explaining panacea. He also points out that, conversely to the interest in substratum, the Germanic superstratum has not received the attention it deserves in the genesis of Catalan because of various prejudices, some of them of an ideological kind.

Particularismes i populismes als països de llengua catalana

2020

[cat] L'article analitza breument l'ampla varietat de conceptes de populisme en la política actual. Aquesta anàlisi intenta mostrar com el populisme ha donat suport als particularismes lingüístics a València i a Mallorca. Aquests particularismes (anomenats blaverisme a València, i gonellisme a Mallorca) no reconeixen la unitat de la comunitat lingüística catalana, i per tant amenacen la recuperació social (normalització) de la llengua catalana.

Synthesis, In Vitro and In Silico Analysis of New Oleanolic Acid and Lupeol Derivatives against Leukemia Cell Lines: Involvement of the NF-κB Pathway

2022

Oleanolic acid (OA) and Lupeol (LU) belong to the class of natural triterpenes and are endowed with a wide range of biological activities, including cytotoxicity toward several cancer cell lines. In this context, we investigated a set of compounds obtained from the two natural precursors for the cytotoxicity against leukemia HL60 cells and the multidrug-resistant (MDR) variant HL60R. Six new semi-synthetic triterpenes have been synthetized, fully characterized, and were investigated together with other triterpenes compounds for their pharmacological mechanism of action. The interaction of the more cytotoxic compounds with the nuclear factor kappa B (NF-κB) pathway has been also evalua…

AD ERUDIENDAM FIDELIUM PLEBEM ESEGESI DEI PRIMI SUNTI SCRITTURALI PALEOSLAVI (ss. IX-XI)

2010

Il sito georgiano di Uplistsikhe e le città rupestri del mondo antico

2015

Rock-cut towns are poorly attested in the Greek-Roman antiquity. One of the most outstanding testimonies is Uplistsikhe, located in the ancient Iberia (today central Georgia), a territory culturally influenced by the classical civilization. This town, after a significant phase already in the Hellenistic period, continued its life until the Middle Ages. In the eyes of a Greek or Roman man, rock-cut settlements could hardly look like real towns. They did not actually follow some urban planning rule and did not impose themselves on the surrounding environment with theirs structures, but effaced themselves in the landscape, without modifying it. As we can also draw from the literary sources, an…

Stellar hydrodynamics with glaister's riemann solver: An approach to the stellar collapse

1990

La resolution de Remann approximee de la solution des equations d'Euler de la dynamique des gaz 1 D, developpee par Glaister P. (1988, J. Comput. Phys., 74) est introduite dans un code hydrodynamique lagrangien et appliquee a l'effondrement stellaire a symetrie spherique

Cryopreservation of Escherichia coli K12TG1: Protection from the damaging effects of supercooling by freezing

2015

Injuries in living cells caused by water freezing during a freeze-thaw process have been extensively reported. In particular, intracellular water freezing has long been incriminated in cell death caused by a high cooling rate, but this supposition could not always be demonstrated. This work aims to discriminate the role of water freezing, dehydration and cold-induced injuries in cellular damage occuring during cryopreservation. For this purpose, Escherichia coli K12TG1 suspensions were maintained in a supercooled or frozen state at -20°C for times ranging from 10 min to 5 h. The supercooled state was maintained for a long period at -20°C by applying a non-injurious isostatic pressure (P<40 …