Search results for "urea"
showing 10 items of 888 documents
Coming to Know Epicurus’ Truth: Distributed Cognition in Lucretius’ De Rerum Natura
2020
Until recently, Descartes' idea that the human mind is, by definition, a non-extended entity (res cogitans, non extensa), enclosed in the body but constitutionally different from common bodily and external realities, found wide acceptance among students of cognitive sciences. But in the past few years the barriers between outer and inner worlds have begun to blur, projecting the process of cognition as a complex distributed phenomenon. According to the so-called distributed cognition thesis (and its more “radical” version, the extended mind hypothesis), “the thinker in this world is a very special medium that can provide coordination among many structured media – some internal, some externa…
Scrittore epicureo anonimo, Opera incerta (PHerc. 1390/908). Edizione, introduzione e commentario, tavole
2019
Il singolare scritto adespoto e anepigrafo trasmesso da PHerc. 1390/908 e convenzionalmente definito ‘Sulla procreazione’ o ‘Sulla generazione’ rappresenta per il suo soggetto un unicum nella collezione ercolanese – dove, com’è noto, non trovano posto opere di natura medica o paramedica – e insieme alla sezione conclusiva del IV libro del De rerum natura di Lucrezio, l’unica trattazione epicurea di una certa estensione sul tema. Di esso, tradizionalmente assegnato a Epicuro e ora attribuito al filosofo epicureo Demetrio Lacone (II secolo a.C.), si propone in questa sede la prima edizione critica complessiva munita di introduzione e commento. The peculiar anonymous text handed down by PHerc.…
Seneca on the Nature of Things: Moral Concerns and Theories of Matter in Natural Questions 6
2017
It is generally recognized that Lucretius' treatment of earthquakes and pestilences (6.535-607; 1090-1286) exerted great influence on Book 6 of Seneca's Natural Questions. But while a large consensus exists that both authors tend to emphasize the moral value of scientific knowledge, further research is needed with respect to Seneca's “technical” re-use of Epicurean physics and meteorology. In the present paper, I shall address this issue in three stages. First, I will analyze the structure and intellectual goals of Seneca's “doxographic” review of seismological theories (6.5-20). Far from being a doxographic account sensu proprio, such a careful review constructs the inspiring image of an i…
Review of M. Beretta, La rivoluzione culturale di Lucrezio. Filosofia e scienza nell'antica Roma (Rome: Carocci, 2015)
2018
By reviewing Marco Beretta's recent book on Lucretius' "cultural revolution" and its intellectual foundations, the present article re-assesses several key issues of the current debate about the literary, philosophical, and scientific value of De Rerum Natura.
Phenoloxidase-dependent cytotoxic mechanism in ascidian (Styela plicata) hemocytes active against erythrocytes and K562 tumor cells.
1997
The cytotoxic activity against rabbit erythrocytes (RE) and human K562 tumor cells by Styela plicata hemocytes was significantly related to the phenoloxidase (PO) which converts phenols to quinone and initiates the melanogenic pathway. The effector hemocyte population, separated in a Percoll density gradient band, enriched in a granulocyte type named "morula cells", was examined with RE in a hemocyte cytotoxic assay and plaque forming cell assay. Inhibition experiments with the copper chelating agents 1-phenyl-2-thiourea and tropolone, the substrate analogue sodium benzoate and sodium ascorbate support the notion that hemocyte cytotoxic activity is a PO-dependent mechanism. Treatments of he…
Representative Bureaucracy and the Role of Expertise in Politics
2015
This is an open access journal from Cogitatio http://www.cogitatiopress.com The vast majority of existing studies on bureaucratic representation focus on bureaucracies’ permanent and internal staff. Yet, the rising sophistication of modern democracies and the technocratization of political life are gradually inducing an increased reliance on external experts to assist in the development and implementation of policy decisions. This trend, we argue, raises the need to extend studies of bureaucratic representation to such external and non-permanent experts in governmental affairs. In this article, we take a first step in this direction using seconded national experts (SNEs) in the European Com…
Control of Enzymic Hydrolysis of Polyadenylate Segment of Messenger RNA: Role of Polyadenylate-Associated Proteins
1978
The role of poly(A)-associated proteins in the breakdown of poly(A) sequences in both mammalian polyribosomes and in isolated poly(A) · protein complexes has been studied on an enzymic level. Two nucleases (alkaline exoribonuclease and endoribonuclease IV; both isolated from eukaryotic tissue), which preferentially hydrolyze poly(A) sequences, have been applied to determine the susceptibility of poly(A) in dependence on the presence of poly(A) · protein(s). Polysomes, isolated from L5178y mouse lymphoma cells, do not contain endogenous poly(A) nuclease activity. The poly(A) segment in polysomes is hydrolyzed by the exoribonuclease, irrespective of the preincubation conditions used. Pretreat…
Accounting for centralization in the European Union : Niskanen, Monnet or Thatcher ?
2002
Centralisation at the level of the European Union takes the form, not so much of increased, staff or budget, but of enlarged responsibilities and an increased share in regulation. The paper first reviews possible explanations of that trend that are based on a view of bureaucracy inspired by, or closely related, to William Niskanen's. It then turns to a discussion of the extent to which any characteristic of the EU machinery can develop without the acquiescenceor agency of a majority of the member-state governments, and of the discussion of whether centralisation as a process is not simply a way to implement, in the manner suggested by Jean Monnet, the "ever closer union" that was - and, to …
The Co‐mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion‐Driven Cholangiocarcinoma
2021
Background and aims Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and a highly lethal malignancy. Chemotherapeutic options are limited, but a considerable subset of patients harbors genetic lesions for which targeted agents exist. Fibroblast growth factor receptor 2 (FGFR2) fusions belong to the most frequent and therapeutically relevant alterations in ICC, and the first FGFR inhibitor was recently approved for the treatment of patients with progressed, fusion-positive ICC. Response rates of up to 35% indicate that FGFR-targeted therapies are beneficial in many but not all patients. Thus far, no established biomarkers exist that predict resistance or r…
Urea as a PCDD/F inhibitor in municipal waste incineration.
2001
Emissions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) from municipal waste incineration have been widely studied because of their extensive toxicity, and many efforts have been made to restrict their emissions. Although a number of chemical compounds have been shown in laboratory-scale tests to inhibit the formation of PCDD/Fs, few have been tested in pilot- or full-scale plants. This work evaluates the effect of urea as a PCDD/F inhibitor in a pilot-scale incinerator that uses refuse-derived fuel (RDF). The decomposition of urea under the test conditions was also studied using detailed kinetic modeling. An aqueous solution of urea was injected into the flue gas stream …