Search results for "urea"
showing 10 items of 888 documents
A new species of Centaurea (Asteraceae) from Calabria(S Italy)
2013
A new species is described here from the Presila in Calabria (S Italy) and named Centaurea calabra. It belongs to Centaurea sect. Phalolepis and is related to the C. deusta group, namely to C. sarfattiana. Taxonomical characteristics, distribution, and ecology of the new Centaurea are also provided.
Centaurea heywoodiana (Asteraceae), a new species from the Nebrodi Mountains (NE-Sicily)
2020
A new endemic species of Centaurea is here described from the Nebrodi Mountains, in Sicily, and named Centaurea heywoodiana. Information on its morphology, distribution, ecology and taxonomic relationship is also provided.
Laboratory parameters in centenarians of Italian ancestry
2008
Studies aimed at collecting reference parameters for haematochemical analysis in the elderly are scarce and for the oldest old subjects even more rare. In order to establish the reference values for the most common laboratory text in long living individuals, we measured haematochemical parameters in >100 years old subjects and in aged subjects as control. Six hundred and two centenarians accepted to be enrolled in the study. A case history containing the complete anamnesis, clinical examinations, evaluation of the clinical cognitive and functional tests, was prepared for each centenarian. Blood samples from 120 > 100 years old subjects free of chronic or acute Illness (i.e. Alzheimer’s dise…
Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.
2011
BackgroundPrevious studies have shown that prenatal exposure to the mutagen N-ethyl-N-nitrosourea (ENU), a N-nitroso compound (NOC) found in the environment, disrupts developmental neurogenesis and alters memory formation. Previously, we showed that postnatal ENU treatment induced lasting deficits in proliferation of neural progenitors in the subventricular zone (SVZ), the main neurogenic region in the adult mouse brain. The present study is aimed to examine, in mice exposed to ENU, both the structural features of adult neurogenic sites, incorporating the dentate gyrus (DG), and the behavioral performance in tasks sensitive to manipulations of adult neurogenesis.Methodology/principal findin…
Il valore della pubblicazione della tesi di laurea di Giovanni Falcone
2021
Questo volume è dato alle stampe a sessant’anni dalla laurea in giurisprudenza di Giovanni Falcone, conseguita con lode il 21 giugno 1961 presso l’Università di Palermo, e a quasi trent’anni dalla strage di Capaci1. 93. L’alto magistrato, come noto, fu ucciso nell’attentato del 23 maggio 1992, nel quale perì insieme alla moglie Francesca Morvillo, anch’essa giudice, e agli agenti della scorta, Rocco Dicillo, Vito Schifani e Antonio Montinaro. L’accertamento delle responsabilità penali a carico dei vertici di Cosa nostra, nell’ambito della strategia dell’eccidio di Capaci, si è concluso con la sentenza della Corte di Cassazione, sez. I, del 18 sett. 2008, nr. 1157, che ha confermato la sente…
(R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors
2015
Purpose The present study aims at developing and evaluating an urea-based prostate specific membrane antigen (PSMA) inhibitor suitable for labeling with 111In for SPECT and intraoperative applications as well as 68Ga and 64Cu for PET imaging. Methods The PSMA-based inhibitor-lysine-urea-glutamate-coupled to the spacer Phe-Phe-D-Lys(suberoyl) and functionalized with the enantiomerically pure prochelator (R)-1-(1-carboxy-3-carbotertbutoxypropyl)-4,7-carbotartbutoxymethyl)-1,4,7-triazacyclononane ((R)-NODAGA(tBu)3), to obtain (R)-NODAGA-Phe-Phe-D-Lys(suberoyl)-Lys-urea-Glu (CC34). CC34 was labeled with 111In, 68Ga and 64Cu. The radioconjugates were further evaluated in vitro and in vivo in LNC…
Synthesis and evaluation of a glibenclamide glucose-conjugate: a potential new lead compound for substituted glibenclamide derivatives as islet imagi…
2007
The search for novel SUR1-ligands originates from the idea to influence the in vivo behaviour by adding new structural moieties to the glibenclamide structure while preserving its binding affinity. Important application of novel conjugates might be their use as radioactively labelled tracer probes in the non-invasive investigation of the islet mass. It is known that the imaging quality of a tracer could be improved by increasing its hydrophilicity, which leads to a reduced plasma protein binding and diminished the unspecific uptake by various organs. In this study the glucose molecule was chosen as a substitute of glibenclamide to enhance hydrophilicity. As expected glucose conjugation lead…
Parliamentary Actors as Politicians
2018
The chapter discusses the horizon of chances of elected parliamentarians as politicians. Parliamentary representation is based on the freedom from dependence with its four classical faces: free speech, free mandate, freedom from arrest as well as free and fair elections. Special attention is given to the dualism between the partisan commitment as the basis of electing members and the freedom from dependence as the basic of parliamentary operations of members. The professionalisation of parliamentarians provides a condition to master the rules of procedure and rhetoric of debate in order to control government and bureaucracy.
Exploring Public Sector’s Roles in Collaborative Consumption – A Research Agenda
2018
Part 2: Digital Collaboration and Social Media; International audience; Motivated by the growing significance of sharing economy within our society, we here discuss which role the public sector may have within collaborative consumption (CC). CC refers to a business model grounded on peer-to-peer based sharing of goods and services through community-based online services. While public sector to a large extent has transformed from formalised bureaucratic structures into more hybrid organisations, focusing on the co-creation between public and private stakeholders, public sector’s role within the sharing economy is still in need for further investigation. We reflect on the need for studying ho…
Representative bureaucracy and seconded national government officials in the European Commission
2015
The bureaucratic arms of modern international organizations increasingly consist of staff with ambiguous organizational affiliations. This article analyses the implications of this trend from the perspective of representative bureaucracy – using seconded national experts (SNEs) in the European Commission (Commission) as the empirical laboratory. Using a variety of datasets, we unveil Commission SNEs' profiles (to assess their passive representativeness) and link these profiles to their role perceptions (to evaluate their potential for active representation). This illustrates that Commission SNEs' background characteristics do not match those of their constituent population (i.e. the EU27 po…