Search results for "uva"
showing 10 items of 2916 documents
German Adjuvant Intergroup Node Positive (GAIN) study: A phase III trial to compare IDD-ETC versus EC-TX in patients with node-positive primary breas…
2014
1009 Background: Intense dose-dense (idd) epirubicin (E), paclitaxel (T), cyclophosphamide (C) (idd-ETC) resulted in a superior disease-free (DFS) and overall survival (OS) compared to conventional...
The effect of obesity on prognosis in operable breast cancer patients treated with adjuvant anthracyclines and taxanes according to pathologic subtyp…
2013
1031 Background: According to observational studies, obesity is an unfavourable prognostic factor in breast cancer (BC), regardless of menopausal status and treatment received. Information collected in clinical trials should confirm this effect and serves to test its homogeneity by pathologic subtype. Methods: We retrospectively analysed 5,683 operable BC patients enrolled in four randomized clinical trials (GEICAM/9906, 9805, 2003–02, and BCIRG 001) evaluating adjuvant anthracyclines and taxanes. Our primary aim was to assess the prognostic effect of body mass index (BMI) on disease recurrence, breast cancer mortality (BCM), and overall mortality (OM). A secondary aim was to detect differ…
Outcome Prediction in Node-Negative Breast Cancer Based on ASCO-Recommended Biomarkers uPA/PAI-1 Using the Final 10-Year Analysis of the Randomized M…
2009
Abstract Background: Based on interim analysis of Chemo N0, the first prospective multicenter randomized clinical trial using biomarkers uPA/PAI-1 for risk stratification and chemotherapy selection in N0 breast cancer, uPA/PAI-1 are now recommended for routine use by ASCO and AGO guidelines. Final 10-year follow-up of Chemo N0 has validated the clinically relevant long-term prognostic and predictive impact of uPA/PAI-1 in N0 breast cancer. To quantify the clinical utility of this impact, outcomes in subgroups defined by these biomarkers were compared to predictions of Adjuvant Online™, the leading validated tool based on established clinical factors. Methods: In Chemo N0, patients (n=647, 1…
Target Therapy in Platinum-Refractory/Resistant Ovarian Cancer: From Preclinical Findings to Current Clinical Practice
2013
Epithelial ovarian cancer (EOC) is the sixth most common malignancy in women. Ovarian tumors consist of several clinical and pathological entities that share an anatomic site. The gold standard treatment, both in front-line and in adjuvant setting, is represented by carboplatin/paclitaxel combination. Conversely, the second-line treatment is not well defined. The response to platinum is the major prognostic factor for survival. In this review we discuss the current views on platinum-refractory/resistant patient treatment only, which includes patients progressing or relapsing within 6 months from the last platinum-based course. Concerning this subgroup, the activity of several conventional d…
In breast cancer, are treatments and survival the same whatever a patient's age? A population-based study over the period 1998-2009
2014
Aim The present study aimed to describe treatments, relative survival and prognostic factors in breast cancer patients according to age. Methods All women with primary invasive breast cancer, diagnosed from 1998 to 2009 in the department of Cote d'Or, were retrospectively selected. Variations in treatments administered according to age ( 74 years) and period were assessed using Cochran–Armitage trend tests and χ2-tests, respectively. Prognostic factors according to age were estimated using a generalized linear model with a Poisson error structure. Results Overall, 4305 women were included. The oldest women (aged >74 years) were more likely than the youngest women to have comorbidities, adva…
Chirurgische Radikalität und Indikation zur adjuvanten Therapie bei malignen Weichteiltumoren — Ergebnisse einer Registerstudie / The Extent of Radic…
2001
Ziel dieser Studie der Chirurgischen Arbeitsgemeinschaft Onkologie (CAO) der Deutschen Gesellschaft fur Chirurgie war die Erfassung eines aktuellen Status des chirurgisch-onkologischen Vorgehens bei malignen Weichteiltumoren des Erwachsenen. In 19 Monaten wurden die Daten von 292 Patienten aus 99 Kliniken prospektiv erfast. 39% wurden an Uni-Kliniken, 36% in Schwerpunkt- und 24% in Krankenhausern der Grundversorgung therapiert. An den Extremitaten konnte in 96% ein extremitatenerhaltender Eingriff durchgefuhrt werden. Die Haufigkeit einer RO-Resektion unterschied sich in den einzelnen Kliniken nicht signifikant, jedoch kamen lokal ausgedehntere Verfahren und additive Masnahmen an Uni-Klinik…
Physical activity of adolescents with long term illnesses or disabilities in reference to ICF personal factors
2016
Participation and activities are important for adolescents’ functioning and health. This is in line with the World Health Organisation’s International Classification of Functioning, Disability and Health (ICF). Main areas of functioning include physical activities (PA) and participation in organised sport clubs. To ensure adolescents with long term illnesses or disabilities (LTID) can participate fully in society, functional abilities interact with contextual environmental and personal factors. Because habits and attitudes of adolescents can carry through to adulthood, it is important to assess the personal factors in relation to activities and participation. Therefore, the aims of this stu…
Health care spending structures in Poland, Latvia, Lithuania and Estonia over the years as compared to other EU countries
2018
Abstract After joining the European Union in 2004, the post-communist countries have dramatically changed their structure of expenditure for medical services. The cause of this is legislative and ownership changes in the new economy. The study analyzed the expenditure on medical services in the European Union with a special focus on Poland, Latvia, Lithuania and Estonia. The European Union countries were divided into clusters using different methods, that is, Ward’s, Two Step and Centroid Clustering. In the paper, the structure and changes in health expenses were presented according to the types of expenditures over the years 2004-2015. Countries were assigned to clusters based on three var…
UV/VIS spectroscopy as a method to characterize well water quality. [UV/VIS-spektroskopi som metod att karakterisera brunnsvattenkvalité]
2016
The applicability of UV/VIS spectroscopy for the characterization of well water quality was studied by analyzing 219 private wells from sparsely populated areas of Finland. In addition to conventional water quality indicators, such as conductivity, nitrate and DOC, a series of UV/VIS spectroscopic parameters were determined: A-224, A-254, A-280, A-365, A-436, the area under 250–350 nm, the area under 250–500 nm, SUVA-254, Molar Absorbance-280, Specific Color, A2/A3 and A2/A4, in order to find the most proper surrogate for the organic matter amount and the best indicator of organic matter quality. Three parameters, A-254, A-280 and the area under 250–350 nm were found to be applicable as sur…
Hardy spaces and quasiconformal maps in the Heisenberg group
2023
We define Hardy spaces $H^p$, $00$ such that every $K$-quasiconformal map $f:B \to f(B) \subset \mathbb{H}^1$ belongs to $H^p$ for all $0<p<p_0(K)$. Second, we give two equivalent conditions for the $H^p$ membership of a quasiconformal map $f$, one in terms of the radial limits of $f$, and one using a nontangential maximal function of $f$. As an application, we characterize Carleson measures on $B$ via integral inequalities for quasiconformal mappings on $B$ and their radial limits. Our paper thus extends results by Astala and Koskela, Jerison and Weitsman, Nolder, and Zinsmeister, from $\mathbb{R}^n$ to $\mathbb{H}^1$. A crucial difference between the proofs in $\mathbb{R}^n$ and $\mathbb{…