Search results for "vaccine."
showing 9 items of 789 documents
Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial
2020
Funding: Transgène; International audience; Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection. TG1050 is an adenovirus 5-based vaccine that expresses HBV polymerase and domains of core and surface antigen and has shown immunogenicity and antiviral effects in mice. We performed a phase 1 clinical trial to assess safety and explore immunogenicity and early efficacy of TG1050 in CHB patients. This randomized, double blind, placebo-controlled study included two sequential phases: one single dose cohort (SD, n = 12) and one …
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrix™ hexa: T…
2014
Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11–12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use in 2000 and has been the only pediatric hexavalent vaccine available since 2005. We reviewed available clinical trial data describing the immunogenicity of DTPa-HBV-IPV/Hib when administered at 3, 5, and 11 mo of age, and conducted an analysis of safety using global and Italian post-marketing surveillance data. In Italy, DTPa-HBV-IPV/Hib has a demonstrated safety record extending over a decade of use, it has been a…
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…
Algunos aspectos de la asimilación de la teoría del contagio animado en la España del siglo XIX
1999
La aceptación de la teoría del contagio animado en España durante el siglo XIX llevó a la superación de la teoría miasmática como explicación del origen de las enfermedades infecciosas y a la integración de las explicaciones parasitológicas de la sarna, la helmintiasis y la tiña, con la vacunación antivariólica y los datos aportados por la nueva microbiología. Ello permitió la resolución de problemas como la infección quirúrgica y la fabricación de sueros y vacunas. El último cuarto de siglo vio la consolidación definitiva de esta teoría, con la aparición de una legislación y unas instituciones específicas dedicadas a la microbiología, así como las primeras exposiciones sistemáticas de la n…
The Role of Existential Concerns in the Individual’s Decisions regarding COVID-19 Vaccine Uptake: A Survey among Non-Vaccinated Italian Adults during…
2022
Recent studies have suggested that health constructs embraced by the Terror Management Theory (TMT) and the Basic Psychological Needs Theory (BPNT) may drive individuals’ COVID-19 health-related decisions. This study examines the relationships between existential concerns (ECs; within the TMT), basic psychological needs (BPNs; within the BPNT) and COVID-19 vaccine hesitancy (VH), as well as the mediating role of negative attitudes toward COVID-19 vaccines. A cross-sectional survey was carried out from April to May 2021 on a sample of two hundred and eighty-seven adults (Mage = 36.04 ± 12.07; 59.9% females). Participants provided information regarding existential concerns, basic psychologica…
Obbligo vaccinale e discrezionalità legislativa a proposito delle ordinanze CGARS nn.38 e 351 del 2022
2022
The paper deals with two ordinances of the CGARS on the subject of vaccination obligation, retracing the events that first led to the preliminary order no. 38/2022 and then to the reasoned order for referral to the constitutional court.
Note a margine dell'ordinanza del Consiglio di giustizia amministrativa della regione siciliana del 17 gennaio 2022 n. 38 in tema di obbligo vaccinal…
2022
This is a comment on the ordinance of the CGA of the Sicilian region on the subject of vaccination obligation in relation to certain categories of subjects.
Obbligo vaccinale e limiti: una recente decisione del Consiglio di Giustizia Amministrativa della Regione Siciliana
2022
This brief paper analyses the obligation of Covid-19 vaccine provided by Italian legislation for workers of the National Health Service. In the order n. 38 of 2022, the Council of Sicilian Administrative Justice decided to verify the possibility to impose mandatory Covid-19 vaccine in relation to Art. 32nd of the Italian Constitution, which provides freedom of self-determination in health choices. Moreover, this principle has to be connected to the general principle of solidarity , enshrined in the Art. 2nd of the Italian Constitution.
The linguistic construction of confirmation niches in online comment sequences
2018
This study starts from the consideration that new media are platforms where communication and language are re-negotiated to adapt new frames (e.g. new politeness, multimodal exchanges) and, in particular, that fora are participatory frameworks, that represent a mined engagement in writing practices (Stommel and Koole, 2010). Discussions are organised as multiparty conversations on several topics, written by participants (i.e website users accessing a parenting forum) at different levels of expertise about health issues (mostly earned through their experience of parenthood; Kata, 2010). the challenge in this paper is : 1) to study asynchronous forum as a talk-in -interaction venue, where seq…