Search results for "vaccines."

Pneumococcal conjugate vaccine for acute otitis media—yes or no?

2003

Synthetic vaccines consisting of tumor-associated MUC1 glycopeptide antigens and a T-cell epitope for the induction of a highly specific humoral immu…

2008

Synthetic vaccines consisting of tumor-associated MUC1 glycopeptide antigens and bovine serum albumin.

2005

Synthetic vaccines of tumor-associated glycopeptide antigens by immune-compatible thioether linkage to bovine serum albumin.

2007

Early and Longitudinal Humoral Response to the SARS-CoV-2 mRNA BNT162b2 Vaccine in Healthcare Workers: Significance of BMI, Adipose Tissue and Muscle…

2022

Background: This study aimed to investigate the early and longitudinal humoral response in Healthcare Workers (HCWs) after two doses of the BNT162b2 vaccine and to assess the association between metabolic and anthropometric parameters and the humoral response after vaccination. Methods: The study included 243 fully vaccinated HCWs: 25.50% previously infected with SARS-CoV-2 (with prior history of COVID-19—PH) and 74.40%—uninfected, seronegative before the first vaccination (with no prior history of COVID-19—NPH). IgG antibodies were measured, and sera were collected: prior to the vaccination, 21 days after the first dose, and 14 days and 8 months after the second dose. Res…

Covid-19 in Philadelphia-negative myeloproliferative neoplasms: a GIMEMA survey on incidence, clinical management and vaccine

2022

Cutaneous Side Effects of Mask Wearing and from the COVID-19 Vaccines

2022

Priekšvēsture: 2019. gada nogalē Vuhānā, Ķīnā, uzliesmojis nezināma vīrusa uzliesmojums ātri izplatījās, un 2020. gada 11. martā PVO pasludināja COVID-19 par globālu pandēmiju. Tāpēc valstis visā pasaulē ieviesa jaunus valdības ierobežojumus. Šī iemesla dēļ sejas masku nēsāšana un vakcinācija pret koronavīrusu pagājušajā gadā kļuva par universālu tematu. Tas radīja jaunas dažādas nevēlamas ādas reakcijas un ādas izskata izmaiņas. Mērķis: Šī pētījuma mērķis bija novērtēt sejas masku un vakcinācijas izraisītās blakusparādības uz ādas un ieteikt profilaksi. Turklāt pētījumam būtu jāpalīdz izprast dažādu faktoru sakarības par to, kā tie ietekmē ādas reakciju iznākumu. Materiāli un metodes: Izma…

Heat shock protein-peptide complexes for use in vaccines

1996

Abstract The heat shock proteins gp96, HSP70, and HSP90 are complexed to a diverse array of cellular proteins and peptides as a consequence of their chaperone functions. There is good experimental evidence that vaccination with these heat shock protein-peptide complexes elicit immune responses against chaperoned peptide antigens. As shown with gp96, this requires internalization of the heat shock protein-peptide complexes by macrophages and processing of the chaperoned peptides for class I restricted presentation. Via this process, primarily CD8+ antigen-specific T cells are primed by gp96 vaccination. This might represent a general mechanism for priming of MHC-class I restricted T cells by…

Initiation of adaptive immune responses by transcutaneous immunization.

2007

The development of new, effective, easy-to-use and lower-cost vaccination approaches for the combat against malignant and infectious diseases is a pre-eminent need: cancer is a leading cause of morbidity in the Western World; there are numerous pathogenic diseases for which we still have no protective or therapeutic cure; and the financial limitations of developing countries to fight these diseases. In this mini-review we focus on transcutaneous immunization (TCI), a relatively new route for antigen delivery. TCI protocols appear to be particularly promising by gaining access to skin resident APC, which are highly efficient for the initiation of humoral and/or cellular immune responses. Con…

Vaccines Through Centuries: Major Cornerstones of Global Health

2015

Multiple cornerstones have shaped the history of vaccines, which may contain live-attenuated viruses, inactivated organisms/viruses, inactivated toxins, or merely segments of the pathogen that could elicit an immune response. The story began with Hippocrates 400 B.C. with his description of mumps and diphtheria. No further discoveries were recorded until 1100 A.D. when the smallpox vaccine was described. During the eighteenth century, vaccines for cholera and yellow fever were reported and Edward Jenner, the father of vaccination and immunology, published his work on smallpox. The nineteenth century was a major landmark, with the "Germ Theory of disease" of Louis Pasteur, the discovery of t…