Search results for "value"

Sequenze di diffusione (DWI) nello studio del carcinoma prostatico: confronto tra b700 e b1400. Nostra esperienza

2014

Materiali e metodi: e' stato analizzato retrospettivamente un campione di 24 pazienti nei quali è stato posto il sospetto RM di CaP confermato all'esame istologico in 20 pazienti. Questi, di età compresa tra 47 e 76 anni (media 64+/- 10), hanno costituito la nostra popolazione. L'esame RM è stato eseguito con un'apparecchiatura da 1.5 T mediante l'ausilio di bobina endorettale. Oltre al protocollo (T2, T1), la valutazione spettroscopica e dinamica postcontrastografica sono state acquisite sequenze DWI sul piano assiale con valori di b pari a 700 e 1400 s/mm2. Le immagini morfologiche e di diffusione sono state analizzate da due radiologi in consenso. E' stato calcolato il coefficiente di di…

Folding energetics and oligomerization of polytopic α-helical transmembrane proteins

2014

While interactions of single-span transmembrane helices have been studied to a significant extent in the past years, the folding of polytopic α-helical transmembrane proteins as well as their oligomerization, are far less analyzed and understood. The goal of the few thus far performed thermodynamic studies, in which unfolding of polytopic TM proteins was described, was to achieve a mild, potentially reversible unfolding process, to finally derive thermodynamic parameters for the reverse folding pathway. In the first part of this review, we summarize the studies analyzing the thermodynamic stability and folding pathways of polytopic transmembrane proteins. Based on these studies, we deduce s…

Template-Directed Protein Folding into a Metastable State of Increased Activity

1995

The principal objective of this work was to distinguish between kinetic and thermodynamic reaction control in protein folding. The deleterious effects of a specific mutation on spontaneous refolding competence were analyzed for this purpose. A Bowman-Birk-type proteinase inhibitor of trypsin and chymotrypsin was selected as a double-headed model protein to facilitate the detection of functional irregularities by the use of functional assays. The parent protein spontaneously folds into a single, fully active and thermodynamically stable state in a redox buffer after reduction/denaturation. By contrast, the properties of a P'1Ser--Pro variant in the trypsin-reactive subdomain differ before an…

Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer

2009

Abstract Purpose: We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling. Experimental Design: The expression levels of cyclins B1, D1, and E1 were quantified in 779 breast tumors and 53 cell lines using reverse phase protein arrays and/or transcriptional profiling. Results: Whereas cyclin E1 overexpression was a specific marker of triple-negative and basal-like tumors, cyclin B1 overexpression occurred in poor prognosis hormone receptor–positive, luminal B and basal-like breast cancers. Cyclin D1 overexpression occurred in lum…

Comparison of classification methods that combine clinical data and high-dimensional mass spectrometry data

2013

Background The identification of new diagnostic or prognostic biomarkers is one of the main aims of clinical cancer research. Technologies like mass spectrometry are commonly being used in proteomic research. Mass spectrometry signals show the proteomic profiles of the individuals under study at a given time. These profiles correspond to the recording of a large number of proteins, much larger than the number of individuals. These variables come in addition to or to complete classical clinical variables. The objective of this study is to evaluate and compare the predictive ability of new and existing models combining mass spectrometry data and classical clinical variables. This study was co…

Missing value imputation in proximity extension assay-based targeted proteomics data

2020

Targeted proteomics utilizing antibody-based proximity extension assays provides sensitive and highly specific quantifications of plasma protein levels. Multivariate analysis of this data is hampered by frequent missing values (random or left censored), calling for imputation approaches. While appropriate missing-value imputation methods exist, benchmarks of their performance in targeted proteomics data are lacking. Here, we assessed the performance of two methods for imputation of values missing completely at random, the previously top-benchmarked ‘missForest’ and the recently published ‘GSimp’ method. Evaluation was accomplished by comparing imputed with remeasured relative concentrations…

The diagnostic protocol of congenital uterine anomalies

2008

Deformed quons and bi-coherent states

2017

We discuss how a q-mutation relation can be deformed replacing a pair of conjugate operators with two other and unrelated operators, as it is done in the construction of pseudo-fermions, pseudo-bosons and truncated pseudo-bosons. This deformation involves interesting mathematical problems and suggests possible applications to pseudo-hermitian quantum mechanics. We construct bi-coherent states associated to $\D$-pseudo-quons, and we show that they share many of their properties with ordinary coherent states. In particular, we find conditions for these states to exist, to be eigenstates of suitable annihilation operators and to give rise to a resolution of the identity. Two examples are discu…

Finite-dimensional pseudo-bosons: a non-Hermitian version of the truncated harmonic oscillator

2018

We propose a deformed version of the commutation rule introduced in 1967 by Buchdahl to describe a particular model of the truncated harmonic oscillator. The rule we consider is defined on a $N$-dimensional Hilbert space $\Hil_N$, and produces two biorhogonal bases of $\Hil_N$ which are eigenstates of the Hamiltonians $h=\frac{1}{2}(q^2+p^2)$, and of its adjoint $h^\dagger$. Here $q$ and $p$ are non-Hermitian operators obeying $[q,p]=i(\1-Nk)$, where $k$ is a suitable orthogonal projection operator. These eigenstates are connected by ladder operators constructed out of $q$, $p$, $q^\dagger$ and $p^\dagger$. Some examples are discussed.

Two-dimensional Noncommutative Swanson Model and Its Bicoherent States

2019

We introduce an extended version of the Swanson model, defined on a two-dimensional noncommutative space, which can be diagonalized exactly by making use of pseudo-bosonic operators. Its eigenvalues are explicitly computed and the biorthogonal sets of eigenstates of the Hamiltonian and of its adjoint are explicitly constructed.We also show that it is possible to construct two displacement-like operators from which a family of bi-coherent states can be obtained. These states are shown to be eigenstates of the deformed lowering operators, and their projector allows to produce a suitable resolution of the identity in a dense subspace of \(\mathcal{L}^\mathrm{2}\, (\mathbb{R}^\mathrm{2})\).