Search results for "value"
showing 10 items of 5321 documents
PValues for Composite Null Models
2000
Abstract The problem of investigating compatibility of an assumed model with the data is investigated in the situation when the assumed model has unknown parameters. The most frequently used measures of compatibility are p values, based on statistics T for which large values are deemed to indicate incompatibility of the data and the model. When the null model has unknown parameters, p values are not uniquely defined. The proposals for computing a p value in such a situation include the plug-in and similar p values on the frequentist side, and the predictive and posterior predictive p values on the Bayesian side. We propose two alternatives, the conditional predictive p value and the partial…
Tests for Differentiation in Gene Expression Using a Data-Driven Order or Weights for Hypotheses
2005
In the analysis of gene expression by microarrays there are usually few subjects, but high-dimensional data. By means of techniques, such as the theory of spherical tests or with suitable permutation tests, it is possible to sort the endpoints or to give weights to them according to specific criteria determined by the data while controlling the multiple type I error rate. The procedures developed so far are based on a sequential analysis of weighted p-values (corresponding to the endpoints), including the most extreme situation of weighting leading to a complete order of p-values. When the data for the endpoints have approximately equal variances, these procedures show good power properties…
A matrix-valued Bernoulli distribution
2006
AbstractMatrix-valued distributions are used in continuous multivariate analysis to model sample data matrices of continuous measurements; their use seems to be neglected for binary, or more generally categorical, data. In this paper we propose a matrix-valued Bernoulli distribution, based on the log-linear representation introduced by Cox [The analysis of multivariate binary data, Appl. Statist. 21 (1972) 113–120] for the Multivariate Bernoulli distribution with correlated components.
Asymptotics for pooled marginal slicing estimator based on SIRα approach
2005
Pooled marginal slicing (PMS) is a semiparametric method, based on sliced inverse regression (SIR) approach, for achieving dimension reduction in regression problems when the outcome variable y and the regressor x are both assumed to be multidimensional. In this paper, we consider the SIR"@a version (combining the SIR-I and SIR-II approaches) of the PMS estimator and we establish the asymptotic distribution of the estimated matrix of interest. Then the asymptotic normality of the eigenprojector on the estimated effective dimension reduction (e.d.r.) space is derived as well as the asymptotic distributions of each estimated e.d.r. direction and its corresponding eigenvalue.
A critical evaluation of the current “p-value controversy”
2017
This article has been triggered by the initiative launched in March 2016 by the Board of Directors of the American Statistical Association (ASA) to counteract the current p-value focus of statistical research practices that allegedly "have contributed to a reproducibility crisis in science." It is pointed out that in the very wide field of statistics applied to medicine, many of the problems raised in the ASA statement are not as severe as in the areas the authors may have primarily in mind, although several of them are well-known experts in biostatistics and epidemiology. This is mainly due to the fact that a large proportion of medical research falls under the realm of a well developed bo…
Optimal designs for a one-way layout with covariates
2000
Abstract For the general class of Φ q -criteria optimal designs are characterized which reflect the inherent symmetry in a one-way layout with covariates. In particular, the eigenvalues of the covariance matrices are related to those in suitably chosen marginal models depending on the underlying interaction structure.
A non-linear optimization procedure to estimate distances and instantaneous substitution rate matrices under the GTR model.
2006
Abstract Motivation: The general-time-reversible (GTR) model is one of the most popular models of nucleotide substitution because it constitutes a good trade-off between mathematical tractability and biological reality. However, when it is applied for inferring evolutionary distances and/or instantaneous rate matrices, the GTR model seems more prone to inapplicability than more restrictive time-reversible models. Although it has been previously noted that the causes for intractability are caused by the impossibility of computing the logarithm of a matrix characterised by negative eigenvalues, the issue has not been investigated further. Results: Here, we formally characterize the mathematic…
The Concept of Duality and Applications to Markov Processes Arising in Neutral Population Genetics Models
1999
One possible and widely used definition of the duality of Markov processes employs functions H relating one process to another in a certain way. For given processes X and Y the space U of all such functions H, called the duality space of X and Y, is studied in this paper. The algebraic structure of U is closely related to the eigenvalues and eigenvectors of the transition matrices of X and Y. Often as for example in physics (interacting particle systems) and in biology (population genetics models) dual processes arise naturally by looking forwards and backwards in time. In particular, time-reversible Markov processes are self-dual. In this paper, results on the duality space are presented f…
Casimir-Polder forces, boundary conditions and fluctuations
2008
We review different aspects of the atom-atom and atom-wall Casimir-Polder forces. We first discuss the role of a boundary condition on the interatomic Casimir-Polder potential between two ground-state atoms, and give a physically transparent interpretation of the results in terms of vacuum fluctuations and image atomic dipoles. We then discuss the known atom-wall Casimir-Polder force for ground- and excited-state atoms, using a different method which is also suited for extension to time-dependent situations. Finally, we consider the fluctuation of the Casimir-Polder force between a ground-state atom and a conducting wall, and discuss possible observation of this force fluctuation.
Complete spectrum and scalar products for the open spin-1/2 XXZ quantum chains with non-diagonal boundary terms
2013
We use the quantum separation of variable (SOV) method to construct the eigenstates of the open XXZ chain with the most general boundary terms. The eigenstates in the inhomogeneous case are constructed in terms of solutions of a system of quadratic equations. This SOV representation permits us to compute scalar products and can be used to calculate form factors and correlation functions.