Search results for "variance"
showing 10 items of 2030 documents
Adaptive linear rank tests for eQTL studies
2012
Expression quantitative trait loci (eQTL) studies are performed to identify single-nucleotide polymorphisms that modify average expression values of genes, proteins, or metabolites, depending on the genotype. As expression values are often not normally distributed, statistical methods for eQTL studies should be valid and powerful in these situations. Adaptive tests are promising alternatives to standard approaches, such as the analysis of variance or the Kruskal-Wallis test. In a two-stage procedure, skewness and tail length of the distributions are estimated and used to select one of several linear rank tests. In this study, we compare two adaptive tests that were proposed in the literatur…
Premature conclusions about the signal‐to‐noise ratio in structural equation modeling research : A commentary on Yuan and Fang (2023)
2023
In a recent article published in this journal, Yuan and Fang (British Journal of Mathematical and Statistical Psychology, 2023) suggest comparing structural equation modeling (SEM), also known as covariance-based SEM (CB-SEM), estimated by normal-distribution-based maximum likelihood (NML), to regression analysis with (weighted) composites estimated by least squares (LS) in terms of their signal-to-noise ratio (SNR). They summarize their findings in the statement that “[c]ontrary to the common belief that CB-SEM is the preferred method for the analysis of observational data, this article shows that regression analysis via weighted composites yields parameter estimates with much smaller stan…
Robust estimation and inference for bivariate line-fitting in allometry.
2011
In allometry, bivariate techniques related to principal component analysis are often used in place of linear regression, and primary interest is in making inferences about the slope. We demonstrate that the current inferential methods are not robust to bivariate contamination, and consider four robust alternatives to the current methods -- a novel sandwich estimator approach, using robust covariance matrices derived via an influence function approach, Huber's M-estimator and the fast-and-robust bootstrap. Simulations demonstrate that Huber's M-estimators are highly efficient and robust against bivariate contamination, and when combined with the fast-and-robust bootstrap, we can make accurat…
Sample-size calculation and reestimation for a semiparametric analysis of recurrent event data taking robust standard errors into account
2014
In some clinical trials, the repeated occurrence of the same type of event is of primary interest and the Andersen-Gill model has been proposed to analyze recurrent event data. Existing methods to determine the required sample size for an Andersen-Gill analysis rely on the strong assumption that all heterogeneity in the individuals' risk to experience events can be explained by known covariates. In practice, however, this assumption might be violated due to unknown or unmeasured covariates affecting the time to events. In these situations, the use of a robust variance estimate in calculating the test statistic is highly recommended to assure the type I error rate, but this will in turn decr…
k-Step shape estimators based on spatial signs and ranks
2010
In this paper, the shape matrix estimators based on spatial sign and rank vectors are considered. The estimators considered here are slight modifications of the estimators introduced in Dümbgen (1998) and Oja and Randles (2004) and further studied for example in Sirkiä et al. (2009). The shape estimators are computed using pairwise differences of the observed data, therefore there is no need to estimate the location center of the data. When the estimator is based on signs, the use of differences also implies that the estimators have the so called independence property if the estimator, that is used as an initial estimator, has it. The influence functions and limiting distributions of the es…
Tests of multinormality based on location vectors and scatter matrices
2007
Classical univariate measures of asymmetry such as Pearson’s (mean-median)/σ or (mean-mode)/σ often measure the standardized distance between two separate location parameters and have been widely used in assessing univariate normality. Similarly, measures of univariate kurtosis are often just ratios of two scale measures. The classical standardized fourth moment and the ratio of the mean deviation to the standard deviation serve as examples. In this paper we consider tests of multinormality which are based on the Mahalanobis distance between two multivariate location vector estimates or on the (matrix) distance between two scatter matrix estimates, respectively. Asymptotic theory is develop…
Exponential and bayesian conjugate families: Review and extensions
1997
The notion of a conjugate family of distributions plays a very important role in the Bayesian approach to parametric inference. One of the main features of such a family is that it is closed under sampling, but a conjugate family often provides prior distributions which are tractable in various other respects. This paper is concerned with the properties of conjugate families for exponential family models. Special attention is given to the class of natural exponential families having a quadratic variance function, for which the theory is particularly fruitful. Several classes of conjugate families have been considered in the literature and here we describe some of their most interesting feat…
SPECTRAL ANALYSIS WITH TAPERED DATA
1983
. A new method based on an upper bound for spectral windows is presented for investigating the cumulants of time series statistics. Using this method two classical results are proved for tapered data. In particular, the asymptotic normality for a class of spectral estimates including estimates for the spectral function and the covariance function is proved under integrability conditions on the spectra using the method of cumulants.
Model comparison and selection for stationary space–time models
2007
An intensive simulation study to compare the spatio-temporal prediction performances among various space-time models is presented. The models having separable spatio-temporal covariance functions and nonseparable ones, under various scenarios, are also considered. The computational performance among the various selected models are compared. The issue of how to select an appropriate space-time model by accounting for the tradeoff between goodness-of-fit and model complexity is addressed. Performances of the two commonly used model-selection criteria, Akaike information criterion and Bayesian information criterion are examined. Furthermore, a practical application based on the statistical ana…
Adaptive Metropolis algorithm using variational Bayesian adaptive Kalman filter
2013
Markov chain Monte Carlo (MCMC) methods are powerful computational tools for analysis of complex statistical problems. However, their computational efficiency is highly dependent on the chosen proposal distribution, which is generally difficult to find. One way to solve this problem is to use adaptive MCMC algorithms which automatically tune the statistics of a proposal distribution during the MCMC run. A new adaptive MCMC algorithm, called the variational Bayesian adaptive Metropolis (VBAM) algorithm, is developed. The VBAM algorithm updates the proposal covariance matrix using the variational Bayesian adaptive Kalman filter (VB-AKF). A strong law of large numbers for the VBAM algorithm is…