Search results for "vault"
showing 10 items of 44 documents
Monitoring of rheologic variables during postoperative high-dose brachytherapy for uterine cancer.
2004
Oxygenation of tumor tissue has recently been assed an important prerequisite for the effectiveness of radiotherapy in cervical cancer. Hyperviscosity is a common phenomenon in malignancy and a cause of reduced oxygen transport capacity that would favour tissue hypoxia. Hemorheological variables were serially tested preoperatively, during four cycles of fractionated adjuvant IR192 HDR after loading radiation (HDR-AL) of the vaginal vault (weekly intervals), and 6 months postoperatively in patients with cervical (n=12) and endometrial cancer (n=26). Women who were scheduled for benign tumor surgery served as controls (n=29). Preoperatively, in cervical and endometrial cancer patients, mean …
Sagittal suture morphological variation in human archaeological populations
2021
Cranial sutures join the many bones of the skull. They are therefore points of weakness and consequently subjected to the many mechanical stresses affecting the cranium. However, the way in which this impacts their morphological complexity remains unclear. We examine the intrinsic and extrinsic mechanisms of human sagittal sutures by quantifying the morphology from 107 individuals from archaeological populations spanning the Mesolithic to Middle ages, using standardized two-dimensional photographs. Results show that the most important factor determining sutural complexity appears to be the position along the cranial vault from the junction with the coronal suture at its anterior-most point …
Genesi geometrica delle volte centriche
1996
Un'analisi completa degli organismi voltati comporta lo studio delle molteplici componenti necessarie alla loro definizione: configurazione geometrica, sistema costruttivo, area storico-geografica di appartenenza, interpretazioni Stilistiche. L’obiettivo di questo studio è indirizzato all' analisi delle volte continue su pianta centrica definibili attraverso le leggi della geometria euclidea. L’indagine si pone all'interno dei confini relativi alla loro configurazione geometrica e il criterio adottato, svincolato da classificazioni di carattere tipologico o stilistico, propone l'identificazione di famiglie geometriche in base alla figura del poligono di base dell'impianto. Si può identifica…
Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer.
2014
Cancer is as much an epigenetic disease as a genetic one; however, the interplay between these two processes is unclear. Recently, it has been shown that a large proportion of DNA methylation variability can be explained by allele-specific methylation (ASM), either at classical imprinted loci or those regulated by underlying genetic variants. During a recent screen for imprinted differentially methylated regions, we identified the genomic interval overlapping the non-coding nc886 RNA (previously known as vtRNA2-1) as an atypical ASM that shows variable levels of methylation, predominantly on the maternal allele in many tissues. Here we show that the nc886 interval is the first example of a …
Alteration of major vault protein in human glioblastoma and its relation with EGFR and PTEN status.
2014
Glioblastoma (GBM) is the most frequent and malignant primary brain tumor. Conventional therapy of surgical removal, radiation and chemotherapy is largely palliative. Major vault protein (MVP), the main component of the vault organelle has been associated with multidrug resistance by reducing cellular accumulation of chemotherapeutic agents. With regard to cancer, MVP has been shown to be overexpressed in drug resistance development and malignant progression. The aim of the present study was to evaluate the MVP gene dosage levels in 113 archival samples from GBM and its correlation with patients' survival and epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog (PTEN) …
Objective vs Subjective Vault Measurement After Myopic Implantable Collamer Lens Implantation
2009
PURPOSE: To evaluate the relationship between subjective measurements of vault and objective values measured with Visante optical coherence tomography (OCT) in eyes receiving an implantable contact lens (ICL) for myopia correction. DESIGN: Observational cross-sectional study. METHODS: SETTING: Fernández-Vega Ophthalmological Institute, Oviedo, Spain. PATIENTS: Four hundred and fifty-two eyes from 246 patients were elected to be implanted with a Visian ICL V4 (STAAR Surgical Inc, Monrovia, California, USA). OBSERVATION PROCEDURES: Subjective and objective measurements of vault after implantation of ICL. MAIN OUTCOME MEASURES: Subjective vault classified in 5 levels assessed using an optical …
Antonio Belguardo. Un maestro nella Palermo tra XV e XVI secolo: il regesto documentario
2016
Le informazioni documentarie emerse in questi ultimi anni sulla figura di Antonio Belguardo permettono di tracciare con maggiore compiutezza il profilo biografico e la parabola professionale di uno dei più prolifici protagonisti della stagione tardogotica dell’architettura siciliana; la sua attività, per quanto sinora noto, si concentra prevalentemente a Palermo tra l’ultimo quarto del XV secolo e i primi decenni del XVI. New documents that have come to light on Antonio Belguardo allow us to draw a more complete biographic profile of one of the most prolific protagonists of Late Gothic Sicilian architecture; His activity, as far as we know, was mainly carried out in Palermo, between the las…
I Barrai, picapedrers cagliaritani della seconda metà del Cinquecento. Stato degli studi e nuove ipotesi
2014
This essay is focused on the Barrai family, a group of stonecutters operating in Cagliari between 15th and 16th centuries. The family played a leading role in the construction and diffusion of star-shaped rib vaults in the late Sardinian 16th centuries religious architecture. The study attempts to systematize available evidence and information about the Barrai family in order to provide a starting point for further investigation. New hypotheses about the family’s genealogy and activity during the second half of the 16th century are also explored.
Ricostruzione virtuale delle crociere dell'aula della chiesa di San Domenico a Cagliari (XVI sec.)
2016
Il saggio affronta la ricostruzione virtuale delle crociere dell’aula della chiesa di San Domenico a Cagliari, distrutta nel 1943 dai bombardamenti alleati che colpirono la città. La ricostruzione virtuale, combinando gli strumenti dell’indagine storica e della rappresentazione digitale, è stata impiegata per comprendere il processo costruttivo della copertura dell’aula. Lo studio ha inoltre permesso di elaborare una più corretta interpretazione dei dettagli linguistici e delle caratteristiche costruttive delle crociere, consentendo di elaborare nuove ipotesi sulla fabbrica, attraverso la comparazione con architetture coeve. This paper focuses on the 3D virtual reconstruction of the star-sh…
Crociere e lunette in Sicilia e in Italia meridionale nel XVI secolo. Dalla costruzione gotica all'affermazione di un modello peninsulare
2016
Se gli studi di storia dell’architettura privilegiano spesso le “avanguardie” e i casi eccezionali, in alcuni contesti aspetti altrettanto importanti per le valutazioni storiografiche emergono da una riflessione su continuità, ripetizioni, serialità. Le ragioni della persistenza o della riproposizione di certe soluzioni non sono infatti sempre le più ovvie o possono risultare meritevoli di ulteriori valutazioni sul peso di alcune componenti piuttosto che di altre. Un ripensamento dei parametri di lettura e del contesto di riferimento può svelare l’infondatezza di alcuni presunti anacronismi; mentre dietro la ripetizione apparentemente inerte si celano non di rado, a un’osservazione più appr…