Search results for "vector"
showing 10 items of 2660 documents
Treatment of Anderson-Fabry Disease
2020
Fabry disease is an X-linked disorder of glycosphingolipid metabolism that results in progressive accumulation of neutral glycosphingolipids, predominantly globotriaosylsphingosine (Gb3) in lysosomes, as well as other cellular compartments of several tissues, causing multi-organ manifestations (acroparesthesias, hypohidrosis, angiokeratomas, signs and symptoms of cardiac, renal, cerebrovascular involvement). Pathogenic mutations lead to a deficiency of the lysosomal enzyme alpha-galactosidase A (GLA). In the presence of high clinical suspicion, a careful physical examination and specific laboratory tests are required. Finally, the diagnosis of Fabry’s disease is confirmed by the demonstrat…
A Comparative Study of Nonlinear Machine Learning for the "In Silico" Depiction of Tyrosinase Inhibitory Activity from Molecular Structure.
2011
In the preset report, for the first time, support vector machine (SVM), artificial neural network (ANN), Baye- sian networks (BNs), k-nearest neighbor (k-NN) are applied and compared on two "in-house" datasets to describe the tyrosinase inhibitory activity from the molecular structure. The data set Data I is used for the identification of tyrosi- nase inhibitors (TIs) including 701 active and 728 inactive compounds. Data II consists of active chemicals for potency estimation of TIs. The 2D TOMOCOMD-CARDD atom-based quadratic indices are used as molecular descriptors. The de- rived models show rather encouraging results with the areas under the Receiver Operating Characteristic (AURC) curve …
Visual acuity with computer simulated and lens-induced astigmatism
2014
[EN] The relationship between spherical and astigmatic refractive errors and their associated visual acuity is investigated in this work by means of two different approaches. In the first one, different refractive errors were induced in normal subjects by trial lenses. In the second one, defocused images were simulated numerically by the optical transfer function of a model eye and then judged by the same subjects. The amount of defocus (measured in terms of the modulus of the dioptric power vector) necessary to reduce the visual acuity to 0.1 logMAR and to 0.4 logMAR was computed with each method and then compared. We found that the visual system is clearly more tolerant to lens-induced de…
CheS-Mapper 2.0 for visual validation of (Q)SAR models
2014
Abstract Background Sound statistical validation is important to evaluate and compare the overall performance of (Q)SAR models. However, classical validation does not support the user in better understanding the properties of the model or the underlying data. Even though, a number of visualization tools for analyzing (Q)SAR information in small molecule datasets exist, integrated visualization methods that allow the investigation of model validation results are still lacking. Results We propose visual validation, as an approach for the graphical inspection of (Q)SAR model validation results. The approach applies the 3D viewer CheS-Mapper, an open-source application for the exploration of sm…
Constraining the spin-dependent WIMP-nucleon cross sections with XENON1T
2019
We report the first experimental results on spin-dependent elastic weakly interacting massive particle (WIMP) nucleon scattering from the XENON1T dark matter search experiment. The analysis uses the full ton year exposure of XENON1T to constrain the spin-dependent proton-only and neutron-only cases. No significant signal excess is observed, and a profile likelihood ratio analysis is used to set exclusion limits on the WIMP-nucleon interactions. This includes the most stringent constraint to date on the WIMP-neutron cross section, with a minimum of 6.3 × 10−42 cm2 at 30 GeV/c2 and 90% confidence level. The results are compared with those from collider searches and used to exclude new paramet…
Combination of Searches for Invisible Higgs Boson Decays with the ATLAS Experiment
2019
Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination of searches for H → invisible decays where H is produced according to the standard model via vector boson fusion, Z(ℓℓ)H, and W/Z(had)H, all performed with the ATLAS detector using 36.1 fb⁻¹ of pp collisions at a center-of-mass energy of √s = 13 TeV at the LHC. In combination with the results at √s = 7 and 8 TeV, an exclusion limit on the H → invisible branching ratio of 0.26(0.17-0.05+0.07) at 95% confidence level is observed (expected).
ELM Regularized Method for Classification Problems
2016
Extreme Learning Machine (ELM) is a recently proposed algorithm, efficient and fast for learning the parameters of single layer neural structures. One of the main problems of this algorithm is to choose the optimal architecture for a given problem solution. To solve this limitation several solutions have been proposed in the literature, including the regularization of the structure. However, to the best of our knowledge, there are no works where such adjustment is applied to classification problems in the presence of a non-linearity in the output; all published works tackle modelling or regression problems. Our proposal has been applied to a series of standard databases for the evaluation o…
Fast relaxation phenomena and slow mode in extended thermodynamics of superfluids
2003
A macroscopic monofluid model of liquid helium II which is based on extended thermodynamics was formulated in previous works, both in the presence and in the absence of dissipative phenomena. In all these studies, the time evolution of the nonequilibrium stress tensor was neglected, putting the relaxation times @t"0 and @t"2 of the nonequilibrium pressure and of the stress deviator equal to zero. In this work, the time evolution of these fields is not neglected and the complete model with 14 fields is studied, in the linear approximation. The propagation of waves is studied and a dispersion relation of degree 14 is obtained. The solutions of this equation are carried out, perturbing the sol…
Elastic waves in random-fibre networks
1997
The propagation of the first displacement maximum of a semi-infinite wavetrain in a two-dimensional random-fibre network is analysed. Model calculations and numerical simulations are used for demonstrating that two qualitatively different wavefront velocities appear in the network. A transient wave, which travels fast and whose amplitude decreases exponentially, dominates the short-time behaviour when the bending stiffness of the fibres is small and the driving frequency is high. This mode can be described by a one-dimensional model. The transient-wave mode propagates even if the bending stiffness of the fibres vanishes, in which case the normal sound velocity is zero. The usual, and slower…
Considerations on the electromagnetic flow in Airy beams based on the Gouy phase
2012
We reexamine the Gouy phase in ballistic Airy beams (AiBs). A physical interpretation of our analysis is derived in terms of the local phase velocity and the Poynting vector streamlines. Recent experiments employing AiBs are consistent with our results. We provide an approach which potentially applies to any finite-energy paraxial wave field that lacks a beam axis. This research was funded by the Spanish Ministry of Economy and Competitiveness under the project TEC2009-11635.