Search results for "vectors"

The Sea Urchin sns5 Insulator Protects Retroviral Vectors From Chromosomal Position Effects by Maintaining Active Chromatin Structure

2009

Silencing and position-effect (PE) variegation (PEV), which is due to integration of viral vectors in heterochromatin regions, are considered significant obstacles to obtaining a consistent level of transgene expression in gene therapy. The inclusion of chromatin insulators into vectors has been proposed to counteract this position-dependent variegation of transgene expression. Here, we show that the sea urchin chromatin insulator, sns5, protects a recombinant gamma-retroviral vector from the negative influence of chromatin in erythroid milieu. This element increases the probability of vector expression at different chromosomal integration sites, which reduces both silencing and PEV. By chr…

Musical pitch quantization as an eigenvalue problem

2020

How can discrete pitches and chords emerge from the continuum of sound? Using a quantum cognition model of tonal music, we prove that the associated Schrödinger equation in Fourier space is invariant under continuous pitch transpositions. However, this symmetry is broken in the case of transpositions of chords, entailing a discrete cyclic group as transposition symmetry. Our research relates quantum mechanics with music and is consistent with music theory and seminal insights by Hermann von Helmholtz.

Incidence and epidemiology of Citrus tristeza virus in the Valencian Community of Spain

2000

Abstract The first outbreak of citrus tristeza disease in Spain caused by Citrus tristeza virus (CTV) was recorded in 1957 in the Valencian Community (VC). In total c. 40 million trees, mainly of sweet orange and mandarin grafted on sour orange rootstocks, declined due to CTV. Large-scale surveys in different municipalities of the VC indicated that the disease spread very fast. Incidence increased from 11% in 1989 to 53% in 1998. Toxoptera aurantii and Aphis spiraecola (inefficient aphid vectors of CTV) predominated before 1985–87. Since then the relatively efficient vector Aphis gossypii has become dominant and induced an epidemic that has been modelled. The large number of A.gossypii that…

PT Symmetry and Weyl Asymptotics

2012

For a class of PT-symmetric operators with small random perturbations, the eigenvalues obey Weyl asymptotics with probability close to 1. Consequently, when the principal symbol is nonreal, there are many nonreal eigenvalues.

Complex powers and non-compact manifolds

2002

We study the complex powers $A^{z}$ of an elliptic, strictly positive pseudodifferential operator $A$ using an axiomatic method that combines the approaches of Guillemin and Seeley. In particular, we introduce a class of algebras, ``extended Weyl algebras,'' whose definition was inspired by Guillemin's paper on the subject. An extended Weyl algebra can be thought of as an algebra of ``abstract pseudodifferential operators.'' Many algebras of pseudodifferential operators are extended Weyl algebras. Several results typical for algebras of pseudodifferential operators (asymptotic completeness, construction of Sobolev spaces, boundedness between apropriate Sobolev spaces, >...) generalize to…

On a class of languages with holonomic generating functions

2017

We define a class of languages (RCM) obtained by considering Regular languages, linear Constraints on the number of occurrences of symbols and Morphisms. The class RCM presents some interesting closure properties, and contains languages with holonomic generating functions. As a matter of fact, RCM is related to one-way 1-reversal bounded k-counter machines and also to Parikh automata on letters. Indeed, RCM is contained in L-NFCM but not in L-DFCM, and strictly includes L-CPA. We conjecture that L-DFCM subset of RCM

Corrigendum to “Imaginary time propagation code for large-scale two-dimensional eigenvalue problems in magnetic fields” [Comput. Phys. Comm. 184(3) (…

2016

Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure

1999

BACKGROUND/AIMSReplication deficient recombinant adenoviruses represent an efficient means of transferring genes in vivo into a wide variety of dividing and quiescent cells from many different organs. Although the gastrointestinal tract is a potentially attractive target for gene therapy approaches, only a few studies on the use of viral gene transfer vehicles in the gut have been reported. The prospects of using recombinant adenoviruses for gene delivery into epithelial and subepithelial cells of the normal and inflamed colon are here analysed.METHODSAn E1/E3 deleted recombinant adenovirus (denoted AdCMVβGal) and an adenovirus with modified fibre structure (denoted AdZ.F(pk7)) both express…

Zur Existenz von Lösungen gewisser Randwertaufgaben

1971

With the aid of some known results about integral equations of the Hammerstein type there is proofed an existence theorem for the following class of boundary value problems−y″−l 2 y′=f(x,y),y(a)=y(b)=0,l 2>0 mit|f(x, y)|=0,l 3 (x)>0. The existence range is determined by the greatest eigenvalue of some linear problem.

Weak commutation relations of unbounded operators and applications

2011

Four possible definitions of the commutation relation $[S,T]=\Id$ of two closable unbounded operators $S,T$ are compared. The {\em weak} sense of this commutator is given in terms of the inner product of the Hilbert space $\H$ where the operators act. Some consequences on the existence of eigenvectors of two number-like operators are derived and the partial O*-algebra generated by $S,T$ is studied. Some applications are also considered.