Search results for "version"
showing 10 items of 1591 documents
Transdiferenciación de fibroblastos a hepatocitos mediante reprogramación celular : papel de Gata4 en el bloqueo de la reprogramación de células somá…
2013
En esta tesis doctoral se muestra la conversión directa de fibroblastos embrionarios de ratón a células con morfología y fenotipo similares al hepatocito mediante la expresión retroviral de seis factores de transcripción hepáticos, Hhex, Gata4, Foxa2, HNF4α HNF1α y HNF6. Los fibroblastos infectados mantenidos durante 3-4 semanas en cultivo adquieren una morfología epitelial y expresan genes típicamente hepáticos como Albumina, Cyp7a1, Tat o Slc10a1 a niveles próximos al hepatocito. Durante la manipulación de los fibroblastos mediante la expresión de los factores de transcripción ya mencionados, observamos que el factor de transcripción Gata4 es capaz de bloquear la reprogramación a células …
Morfina, alkohol, kokaina, czyli pomieszanie z poplątaniem w "Matce" Witkacego
2016
Tematem mojego artykułu jest problem używek przedstawiony w Matce Stanisława Ignacego Witkiewicza. Nadużywanie alkoholu i narkotyków, służące złagodzeniu bólu istnienia to - w kontekście omawianego utworu - zagłuszanie metafizycznych lęków nie tylko prezentowanych w nim postaci, ale także samego autora. Na przykładzie inscenizacji Jerzego Jarockiego z Teatru Starego w Krakowie opisuję złożoność relacji postaci, które dławiąc się własnym cierpieniem, popadają w nałogi. Zarówno dramat, jak i jego teatralna konkretyzacja stanowią laboratorium udręki wzajemnego bytowania, studium destrukcyjnej siły rodzinnych związków. Tutaj wszystko może się zdarzyć i na pewno będzie na „nie".
The contribution of the pre-existing structures in mountain belt evolution: the example of the negative inversion in the Northen Sicily
2004
Syn-orogenic extension has been recognised in Northern Sicily. Mesoscopic analysis has been carried out in three key areas, where folded-and-thrust Mesozoic-to-Tertiary rocks crop-out. The three examples are inherent to Portions Of tectonic Units Which occupy progressively more internal positions in the Sicilian chain from west to east. The extensional deformation is mainly represented by low-angle normal faults and shear bands. A common kinematic process seems to affect the other sector of the chain during the extension and is represented by a generalized negative inversion of previous layer-parallel shear bands and detachments related to the thrusting. The extensional deformation occurred…
EVALUATING THE RISK OF HEPATITIS B REACTIVATION IN PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES: IS THE SERUM HEPATITIS B PROFILE RELIABLE?
2009
Background/Aim: Patients with an occult hepatitis B virus (HBV) infection undergoing deep immunosuppression are potentially at risk of HBV reactivation. In order to assess whether a polymerase chain reaction (PCR) assay for HBV DNA in serum could be used to predict the reactivation of an occult HBV infection, we performed a retrospective study in a cohort of Sicilian patients with oncohaematological diseases. Methods: We studied by a highly sensitive ad hoc nested PCR for serum HBV DNA 75 HBsAg-negative oncohaematological patients requiring chemotherapy. Results: Thirty-three patients (44%) were HBV seronegative (anti-HBc and anti-HBs negative) and 42 patients (56%) were HBV seropositive (a…
Translanguaging as Playful Subversion of a Monolingual Norm in the Classroom
2018
A large part of the literature on translanguaging as a pedagogical theory has explored how an inclusive multilingual pedagogy can support students from diverse linguistic and cultural backgrounds to actively participate in the classroom. While much of this literature approaches classroom translanguaging as an instructional strategy designed to promote multilingual interactional practices, we analyse how multilingual practices can also take place as subversive language play in an educational context that is driven by a monolingual norm. Our data are video-recorded lessons from secondary-level Content and Language Integrated Learning (CLIL) classrooms in Finland in which students whose L1 is …
Towards Dynamic Ontology - Integrating Tools of Evolution and Versionning in Ontology
2010
6; International audience; Since Gruber's definition, a lot of works focused on evolution or versioning issues. Not much attention has been paid to integrated solutions which resolve both these two purposes. In this paper we present a new semantic architecture that combines versioning tools with the evolution process. This architecture called VersionGraph is integrated in the source ontology since its creation in order to make it possible to evolve and to be versioned.
Internal conversion from excited electronic states of 229Th ions
2017
The process of internal conversion from excited electronic states is investigated theoretically for the case of the vacuum-ultraviolet nuclear transition of 229 Th . Due to the very low transition energy, the 229 Th nucleus offers the unique possibility to open the otherwise forbidden internal conversion nuclear decay channel for thorium ions via optical laser excitation of the electronic shell. We show that this feature can be exploited to investigate the isomeric state properties via observation of internal conversion from excited electronic configurations of Th + and Th 2 + ions. A possible experimental realization of the proposed scenario at the nuclear laser spectroscopy facility IGISO…
Net currents obtained from zero-average potentials in single amphoteric nanopores
2013
We have studied experimentally and theoretically the rectifying properties of a single asymmetric nanopore functionalized with amphoteric lysine groups and characterized the net current obtained with zero-average time dependent potentials. The pH-controlled rectification phenomena may be relevant to bio-electrochemistry, pH sensing and regulation, and energy conversion. (C) 2013 Elsevier B.V. All rights reserved.
Dziecko w roli rodzica – pomylone role rodzinne. O parentyfikacji w doniesieniach światowych i polskich
2018
Cel. Celem artykułu, o charakterze przeglądowym, jest wyjaśnienie zjawiska parentyfikacji, jej uwarunkowań i konsekwencji z nią związanych. Parentyfikacja najczęściej określana jest jako odwrócona rola w rodzinie i dotyczy zamiany roli między rodzicem a dzieckiem. Dochodzi do niej wówczas gdy rodzic, częściowo lub całkowicie rezygnuje ze swoich zadań i obowiązków rodzicielskich. Abdykacja rodzica uruchamia proces parentyfikacji, w którym zwykle jedno, najczęściej najstarsze dziecko w rodzinie, czuje się oddelegowane do przejęcia roli rodzicielskiej, w różnych sferach życia rodzinnego. Świadoma pomoc i obowiązki mogą mieć charakter instrumentalny lub emocjonalny. Dziecko poddane procesowi pa…
Gravity-derived Moho map for Latvia
2020
A precise understanding of crustal structure is essential to the fields of geodynamics, seismology and certain branches of geophysics. A boundary between the crust and the mantle is known as the MohoroviÄiÄ discontinuity, simply referred to as the âMohoâ. Moho geometry and depth have been extensively studied in Europe, but there are still regions with little information about it. One such area is the northern Baltics, Latvia in particular. So far, only one seismic refraction profile, spanning from Sovetsk (Kaliningrad) to Kohtla-Järve (Estonia), has been used to study the deep structure of the Earth in Latvia. We propose gravity inversion (ParkerâOldenburg algorithm) to gain more insight i…