Search results for "virtual"
showing 10 items of 1485 documents
Ten Words About Morphogenetic Images
2018
This chapter describes how the repertoire of images derived from morphogenetic shaping processes is widely studied in every scientific and humanistic field. These are from the pioneering experiences of cinematic, programmed and generative arts of the 1960s and 1970s, the utopian digital space spells in the ‘90s, the morphogenetic architectural projects in the early 2000s, to the latest experiences. It is possible to look at these currents with a critical look detached from the time distance that has developed. Many denominations indicate processes and experiences in different fields but result from a common intellectual matrix. This is used to generate shapes, figures, spaces or images from…
Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening
2013
The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50 confirmed its specific influence on the cellular pathways involving Hsp90.
Development of a test station for accurate in situ I-V curve measurements of photovoltaic modules in Southern Norway
2011
The development of an outdoor test station for accurate in situ I-V curve measurements of photovoltaic (PV) modules is described. The modules are installed in an open-rack configuration at the University of Agder in Southern Norway. Seven new and three aged PV modules of different type and make are being tested, including mono-and multicrystalline silicon from differing manufacturing routes, triple-junction amorphous silicon, and CIS. Data acquisition is controlled with a multichannel electronic load system and LabVIEW software, recording high-resolution I-V curves at one-minute intervals. Between I-V curve sweeps, each module is operated at the maximum power point. Characteristic electrica…
I modelli digitali come strumento per lo studio dell'architettura antica: l'anastilosi virtuale
2017
The contribution concerns the methodology for the reconstructive study of ancient monuments with particular reference to the concept of Virtual Anastylosis. This contribution illustrates the work carried out within the project of the exhibition "Living in Selinunte, from the origins to the Middle Ages", with particular reference to the virtual reconstruction of the North Gate and the FF1 block.
Ipotesi di ricostruzione virtuale della piazza maggiore a Noto Antica
2019
Today ancient Noto is a medieval archaeological site, yet to be discovered. After the 1693 earthquake, the ancient city of Noto, in the middle of the Baroque period, was rebuilt in another place and the ancient city was abandoned. The first excavation campaign in ancient Noto by Paolo Orsi dates back to the period between 1894 and 1896. In the following years there will be other excavation campaigns, in which other architectural and sculptural relics will be found. They are today part of the collection of the Civic Museum. The contribution focuses on the study of the piazza Maggiore (Main Square) site, the center of the ancient city and on the surrounding buildings. After analyzing the limi…
Generalized power-angle control for grid-forming converters: A structural analysis
2022
Several control schemes have been recently proposed and studied as grid-forming controls for power converters. In all these schemes, the power-angle control loop is the part which defines the fundamental capabilities of the grid-forming control: that control loop governs in fact the inherent synchronization mechanism of the power converter, the power sharing with the other generation sources in the system and the oscillatory characteristics of the converter-based resource. This article introduces a general formulation for the power-angle control characterizing the grid-forming concept for power converters. The generalized power-angle control is based on a polynomial fraction formulation, an…
A gradient elasticity theory for second-grade materials and higher order inertia
2012
Abstract Second-grade elastic materials featured by a free energy depending on the strain and the strain gradient, and a kinetic energy depending on the velocity and the velocity gradient, are addressed. An inertial energy balance principle and a virtual work principle for inertial actions are envisioned to enrich the set of traditional theoretical tools of thermodynamics and continuum mechanics. The state variables include the body momentum and the surface momentum, related to the velocity in a nonstandard way, as well as the concomitant mass-accelerations and inertial forces, which do intervene into the motion equations and into the force boundary conditions. The boundary traction is the …
Atom, atom-type and total molecular linear indices as a promising approach for bioorganic and medicinal chemistry: theoretical and experimental asses…
2004
Abstract Helminth infections are a medical problem in the world nowadays. In this paper a novel atom-level chemical descriptor has been applied to estimate the anthelmintic activity. Total and local linear indices and linear discriminant analysis were used to obtain a quantitative model that discriminates between anthelmintic and non-anthelmintic drug-like compounds. The discriminant model has an accuracy of 90.11% in the training set, with a high Matthews’ correlation coefficient (MCC = 0.80). To assess the robustness and predictive power of the obtained model, internal (leave-n-out) and external validation process was performed. The QSAR model correctly classified 88.55% of compounds in t…
Recent advances in computational design of potent aromatase inhibitors: open-eye on endocrine-resistant breast cancers.
2019
Introduction: The vast majority of breast cancers (BC) are estrogen receptor positive (ER+). The most effective treatments to fight this BC type rely on estrogen deprivation therapy, by inhibiting the aromatase enzyme, which performs estrogen biosynthesis, or on blocking the estrogens signaling path via modulating/degrading the estrogen's specific nuclear receptor (estrogen receptor-?, ER?). While being effective at early disease stage, patients treated with aromatase inhibitors (AIs) may acquire resistance and often relapse after prolonged therapies. Areas covered: In this compendium, after an overview of the historical development of the AIs currently in clinical use, and of the computati…
Anàlisi de les interaccions en fòrums de discussió a través del Campus Andalús Virtual
2012
En el presente trabajo se expone un análisis de las interacciones que se producen en una experiencia formativa a través del Campus Andaluz Virtual. Para ello, se han analizado un total de 284 cuestionarios de evaluación, así como 1538 mensajes que se han intercambiado en los foros de discusión destinados al trabajo colaborativo para resolver tareas académicas. Los resultados nos indican cuáles son los factores más importantes de una comunidad de aprendizaje y cuáles han sido las intervenciones más frecuentes en la realización de tareas de aprendizaje cooperativo en red.