Search results for "well"
showing 10 items of 2241 documents
Subjective well-being key elements of Successful Aging: A study with Lifelong Learners older adults from Costa Rica and Spain.
2019
Abstract Subjective well-being is a major psychological construct in the research tradition. Along with literature, authors have distinguished between hedonic and eudaimonic well-being. The aim of this study is to determine the role of some psychosocial variables plays in the perceived well-being is conceived from a hedonic or a eudaimonic perspective. The sample consisted of 1016 people of 55 years and older in a Spanish sample and 277 people of 55 years old or older from a Costa Rican sample. Both samples were part of the Longitudinal Older Learners (LOL) study. A structural model with latent variables was estimated with Mplus. The results point out that, the traditional variables include…
Frailty and incident depression in community-dwelling older people: results from the ELSA study
2016
Objective: Frailty and pre-frailty are two common conditions in the older people, but whether these conditions could predict depression is still limited to a few longitudinal studies. In this paper, we aimed to investigate whether frailty and pre-frailty are associated with an increased risk of depression in a prospective cohort of community-dwelling older people. Methods: Four thousand seventy-seven community-dwelling men and women over 60 years without depression at baseline were included from the English Longitudinal Study of Ageing. Frailty status was defined according to modified Fried's criteria (weakness, weight loss, slow gait speed, low physical activity and exhaustion) and categor…
Multidimensional Sexual Well-being Scale for Older Adults: Validity Evidence from a Polish Sample
2021
Here, we report the results of a Polish adaptation of the Multidimensional Sexual Well-being Scale (MSWBS) for older adults. The MSWBS is a short self-report scale for assessing the five dimensions of an individual's sexual well-being: frequency of caressing, sexual intimacy, sexual compliance, sexual satisfaction, and sexual distress. The aim of our adaptation was to examine the utility of the scale in a country with conservative views on the sexuality of older people, which will help health care providers and researchers to better understand the sexual needs of older people. The study included 507 participants, aged 60-92. We found the reliability of the scale to be satisfactory (Cronbach…
Happiness in advanced adulthood and elderly: The role of positive emotions, flourishing and mindfulness as wellbeing factors for successful ageing
2019
This study critically analyses the role of Happiness among the Portuguese elderly. The term is understood as a grouping of variables including Subjective Well-being, defined by satisfaction with life, positive and negative affects, flourishing, optimism and pessimism, positive and negative emotions, meaning of life, religiosity, Spirituality, and mindfulness. The qualities of Happiness are explored as they contribute to successful ageing and higher levels of Happiness in the elderly. We conducted a correlational study of 329 participants, aged 55 to 98 years. We used several questionnaires to gather data as a socio-demographic questionnaire, Satisfaction with Life Scale (SWLS), Positive and…
Do aging employees benefit from self-regulative strategies? : A follow-up study
2020
SOC-strategies (selection, optimization, and compensation) are crucial for well-being and adaptation throughout the life course. The workforce is aging rapidly, thus the age-conditional premises of SOC theory require attention. This study explored (1) whether older employees used SOC strategies more often (compared to younger employees), and (2) whether older employees benefited more from SOC strategies in relation to occupational well-being (job burnout, work engagement). The study was based on follow-up data including three occupational subsamples of different age (N = 1,020). There were no significant age-conditional differences in the take-up of SOC strategies. However, older (white-col…
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness…
2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions a…
Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults
2020
Abstract Background In 2016, an expert working group was convened under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and formulated consensus recommendations for the conduct of clinical trials for drugs to prevent or treat sarcopenia. Aims The objective of the current paper is to provide a 2020 update of the previous recommendations in accordance with the evidence that has become available since our original recommendations. Methods This paper is based on literature reviews performed by members of the ESCEO working group and followed up with face to face meetings organized for the whole group to make amendments and discuss…
The age and well-being “paradox”: a longitudinal and multidimensional reconsideration
2022
This paper explores qualifcations to the much-discussed paradox that although aging is associated with multiple physical and social losses, subjective well-being (SWB) is stable or increasing in later life. We explore age-related changes in cognitive, afective, and eudaimonic dimensions in three waves of data spanning up to 15 years from the Norwegian NorLAG study (N=4,944, age 40−95). We employ fxed-efect models to examine the nature and predictors of aging efects on SWB. Results indicate a general pattern of stability well into older age, but negative changes in advanced age across well-being measures. Declines in SWB are less pronounced and with a later onset for the cognitive compared w…
Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines
2021
Abstract Background Next Generation Sequencing (NGS) is the fundament of various studies, providing insights into questions from biology and medicine. Nevertheless, integrating data from different experimental backgrounds can introduce strong biases. In order to methodically investigate the magnitude of systematic errors in single nucleotide variant calls, we performed a cross-sectional observational study on a genomic cohort of 99 subjects each sequenced via (i) Illumina HiSeq X, (ii) Illumina HiSeq, and (iii) Complete Genomics and processed with the respective bioinformatic pipeline. We also repeated variant calling for the Illumina cohorts with GATK, which allowed us to investigate the e…