Search results for "will"

showing 10 items of 546 documents

2014

AbstractAssays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi-parameter flow assay to characterize thrombus formation in whole blood from healthy subjects and patients with platelet function deficiencies. A systematic comparison is made of 52 adhesive surfaces with components activating the main platelet-adhesive receptors, and of eight output parameters reflecting distinct stages of thrombus formation. Three types of thrombus formation can be identified with a predicted hierarchy of the following receptors: glycoprotein (GP)VI, C-type lectin-like receptor-2 (CLEC-2)&g…

Pathologymedicine.medical_specialtyMultidisciplinarybiologybusiness.industryGeneral Physics and AstronomyGeneral ChemistryFibrinogenmedicine.diseaseThrombosisGeneral Biochemistry Genetics and Molecular BiologyThrombastheniaVon Willebrand factorImmunologybiology.proteinmedicinePlateletThrombusbusinessReceptormedicine.drugWhole bloodNature Communications
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Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke with and without metabolic syndrome.

2014

Objective: The aim of our study was to evaluate the associations between arterial stiffness indexes and immune-inflammatory markers in subjects with acute ischemic stroke with and without metabolic syndrome. Materials/Methods: We enrolled 130 patients with acute ischemic stroke and metabolic syndrome, 127 patients with acute ischemic stroke without metabolic syndrome and 120 control subjects without acute stroke. Applanation tonometry was used to record the augmentation index (Aix) and pulse wave velocity (PWV). We also evaluated plasma levels of C-reactive protein (CRP), Interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), Interleukin-6 (IL-6) and Interleukin-10 (IL-10), E-selec…

Pathologymedicine.medical_specialtySettore MED/09 - Medicina InternaEndocrinology Diabetes and MetabolismStroke arterial stiffness metabolic syndromeTissue plasminogen activatorVon Willebrand factorDiabetes mellitusInternal medicineInternal Medicinemedicinecardiovascular diseasesPulse wave velocityStrokePWVbiologyAixbusiness.industryResearchmedicine.diseaseArterial stiffnessStrokebiology.proteinArterial stiffnessCardiologyCytokinesMetabolic syndromebusinessPlasminogen activatormedicine.drug
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Half-width plots, a simple tool to predict peak shape, reveal column kinetics and characterise chromatographic columns in liquid chromatography: Stat…

2013

Peak profiles in chromatography are characterised by their height, position, width and asymmetry; the two latter depend on the values of the left and right peak half-widths. Simple correlations have been found between the peak half-widths and the retention times. The representation of such correlations has been called half-width plots. For isocratic elution, the plots are parabolic, although often, the parabolas can be approximated to straight-lines. The plots can be obtained with the half-widths/retention time data for a set of solutes experiencing the same kinetics, eluted with a mobile phase at fixed or varying composition. When the analysed solutes experience different resistance to mas…

Peak profiles in chromatography are characterised by their height position width and asymmetry; the two latter depend on the values of the left and right peak half-widths. Simple correlations have been found between the peak half-widths and the retention times. The representation of such correlations has been called half-width plots. For isocratic elution the plots are parabolic although often the parabolas can be approximated to straight-lines. The plots can be obtained with the half-widths/retention time data for a set of solutes experiencing the same kinetics eluted with a mobile phase at fixed or varying composition. When the analysed solutes experience different resistance to mass transfer the plots will be solute dependent and should be obtained with the data for each solute eluted with mobile phases at varying composition. The half-width plots approach is a simple tool that facilitates the prediction of peak shape (width and asymmetry) with optimisation purposes reveal the interaction kinetics of solutes in different columns and characterise chromatographic columns. This work shows half-width plots for different situations in isocratic elution including the use of different flows the effect of temperature the modification of the stationary phase surface by an additive the existence of specific interactions within the column and the comparison of columns. The adaptation to gradient elution is also described. Previous knowledge on half-width plots is structured and analysed to which new results are added.Work (thermodynamics)Column characterisationmedia_common.quotation_subjectKineticsLiquid chromatographyAnalytical chemistryHalf-widthsInteraction kineticsBiochemistryAsymmetryAnalytical ChemistryPeak shapeColumn (typography)Position (vector)Mass transferPhase (matter)media_commonChromatographyElutionChemistryOrganic ChemistryGeneral MedicineModels TheoreticalKineticsPredictionChromatography LiquidJournal of Chromatography A
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Landowners’ willingness to promote bioenergy production on wasteland − future impact on land use of cutaway peatlands

2017

Landowners are the key players in bioenergy production on wasteland; such as cutaway peatlands. In this study, the landowner's interest to use cutaway peatlands for bioenergy production was investigated using a survey and GIS (Geographic Information Systems) methods in an area in South Ostrobothnia, Finland. The focus was to identify which different bioenergy production chains are preferred by the respondents: combustion, gasification or biogas production from agriculture, energy-willow short-rotation forestry or forestry based energy crops. Also, the influence of personal environmental values on the selection was measured and the future impacts and barriers for the land use were assessed. …

Peat010504 meteorology & atmospheric sciences020209 energyta1172Geography Planning and DevelopmentgasificationBiomasspajutmaankäyttö02 engineering and technologyManagement Monitoring Policy and Law01 natural sciencesjoutomaaBioenergybiogas0202 electrical engineering electronic engineering information engineeringAfforestationbiopolttoaineetenergiakasvitLand tenureta2180105 earth and related environmental sciencesNature and Landscape ConservationwillowbiokaasuLand use218 Environmental engineeringAgroforestrybusiness.industrymaanomistajatForestryGISenergy cropEnergy crop214 Mechanical engineeringAgricultureEnvironmental sciencebusinesscombustionLand Use Policy
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Patients’ and physicians’ preferences for type 2 diabetes mellitus treatments in Spain and Portugal: a discrete choice e…

2015

Carlos Morillas,1 Rosa Feliciano,2 Pablo Fernández Catalina,3 Carla Ponte,4 Marta Botella,5 João Rodrigues,6 Enric Esmatjes,7 Javier Lafita,8 Luis Lizán,9 Ignacio Llorente,10 Cristóbal Morales,11 Jorge Navarro-Pérez,12 Domingo Orozco-Beltran,13 Silvia Paz,9 Antonio Ramirez de Arellano,14 Cristina Cardoso,15 Maribel Tribaldos Causadias9 1Hospital Universitario Dr Peset, Valencia, Spain; 2USF São Domingos, Santarém, Portugal; 3Hospital Montecelo de Pontevedra, Galicia, Spain; 4USF Porta do Sol, Matosinhos, Portugal; 5Hospital Universitario Principe de Asturias, Madrid, Spain; 6USF Serra da Lousã, Lous&…

Pediatricsmedicine.medical_specialtybusiness.industryHealth PolicyMedicine (miscellaneous)Hypoglycemiamedicine.diseaseLogistic regressionConfidence intervalchemistry.chemical_compoundPatient Preference and AdherencechemistryWillingness to payWeight lossMedicineOutpatient clinicGlycated hemoglobinmedicine.symptombusinessPharmacology Toxicology and Pharmaceutics (miscellaneous)Body mass indexSocial Sciences (miscellaneous)Patient Preference and Adherence
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Descriptive Evaluation of Age-Related Differences in Clinical Manifestation and Treatment of Von Willebrand's Disease in an Open-Label, Prospective, …

2012

Abstract Abstract 4630 Efficacy, tolerability and dosing of a VWF/FVIII concentrate may differ in paediatric, adults, and elderly patients. It is therefore reasonable to collect and evaluate clinical data of patients from different age groups and to look into differences in treatment and reason for treatment with VWF/FVIII concentrate. A cohort of 120 patients suffering from all types of von Willebrand's disease (VWD) from an on-going German post-marketing surveillance study was analysed for age-related differences in treatment with a high-purity, double virus inactivated VWF/FVIII concentrate (wilate®). Results: Thirteen children up to 12 years of age and 14 patients being 65 or older were…

Pediatricsmedicine.medical_specialtybusiness.operationDosebusiness.industryReason for TreatmentImmunologyCell BiologyHematologyDiseaseOctapharmaBiochemistryVon willebrandTolerabilityCohortmedicineDosingbusinessBlood
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Final Evaluation Of a Prospective, Non-Interventional Study On Efficacy and Tolerability Of a New Generation VWF/FVIII Concentrate In The Treatment O…

2013

Background With marketing authorization in 2005, a non-interventional study (SET = Surveillance of Efficacy and Tolerability) with a double virus inactivated VWF/FVIII concentrate (Wilate®) was initiated in Germany. In 2012, the inclusion of patient documentation was terminated for final evaluation of the study data, representing the treatment of 170 patients suffering from von Willebrand’s disease (VWD). Aim The presented study was performed to assess the haemostatic efficacy and safety of a newly introduced VWF/FVIII product in the treatment of all types of VWD patients in every day clinical setting and to validate the results from pivotal clinical trials. Methods Patients of any age suf…

Pediatricsmedicine.medical_specialtybusiness.operationbusiness.industryImmunologyCell BiologyHematologyDiseasemedicine.diseaseOctapharmaBiochemistryClinical trialRegimenDisease severityTolerabilityNon interventionalVon Willebrand diseasemedicinebusinessBlood
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La vida cotidiana de los vecinos de Manila a través de sus testamentos e inventarios de bienes

2019

With the general objective indicated in its title, this work tries to highlight relevant aspects in the continuity of the Spanish domain in the Philippines, dependent on the maintenance of the Spanish capital. The inevitable selection of topics has lead the preferences of this work towards the residents collaboration to defend the city, the conversion of many of them into traders of exotic products and singular slaves owners, and their collaboration to an incredible miscegenation due to the ethnic variety. On the other hand, to follow the footsteps of the first generation of residents in Manila, at the end of the 16th century and during the 17th century, this work gives us some information …

PhilippinesRevista de historia moderna 529735 2019 45 7107712 La vida cotidiana de los vecinos de Manila a través de sus testamentos e inventarios de bienes García Abásolo [0210-9093 553 Estudis]and their collaboration to an incredible miscegenation due to the ethnic variety. On the other handAntonio With the general objective indicated in its titlesiglos xVI a xVIIIesclavitudfrom the 16th to the 18th centurywillsvida cotidianaat the end of the 16th century and during the 17th century:HISTORIA [UNESCO]vecinosdependent on the maintenance of the Spanish capital. The inevitable selection of topics has lead the preferences of this work towards the residents collaboration to defend the cityMexicothis work gives us some information about the flexibility of the Hispanic Monarchy to adapt to the social surroundings in Asia. FilipinasUNESCO::HISTORIA0210-9093 553 Estudis: Revista de historia moderna 529735 2019 45 7107712 La vida cotidiana de los vecinos de Manila a través de sus testamentos e inventarios de bienes García Abásoloto follow the footsteps of the first generation of residents in ManilaMéxicothe conversion of many of them into traders of exotic products and singular slaves ownersdaily lifeManilacommercethis work tries to highlight relevant aspects in the continuity of the Spanish domain in the Philippinesresidentscomerciotestamentosslavery 69 92
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Introduction: responsibility for action and belief

2009

Research on moral responsibility and the related problem of free will is among the liveliest areas in contemporary analytical philosophy. Traditionally, these problems have been dealt with in conne...

PhilosophyAnalytic philosophyAction (philosophy)media_common.quotation_subjectFree willMoral responsibilitySociologyEpistemologymedia_commonPhilosophical Explorations
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¿Tiene arraigo en el cerebro la libertad?

2017

El artículo se propone, en primer lugar, ofrecer un nuevo concepto de naturaleza humana, más allá de la metafísica tradicional y de la interpretación naturalista de las actuales neurociencias, superando así la unilateral apropiación cientificista del concepto de naturaleza humana y defendiendo una biohermenéutica, que cuenta con la pluralidad de perspectivas para comprender la realidad humana, como en el dualismo epistémico habermasiano. En segundo lugar, se indaga si en el cerebro tiene arraigo la libertad en el sentido de «libre albedrío» y de «autonomía», teniendo en cuenta la posición de acreditados neurólogos y el estudio de las disposiciones naturales en la concepción kantiana de la a…

PhilosophyAppropriationmedia_common.quotation_subjectInterpretation (philosophy)DualismFree willMetaphysicsNatural (music)SociologyAutonomyNaturalismmedia_commonEpistemologyPensamiento. Revista de Investigación e Información Filosófica
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