Search results for "work analysis"
showing 10 items of 232 documents
Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity
2017
Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages. We identified multiple signaling pathways that trigger distinct downstream transcriptional networks to regulate the diversity of neural cells …
Redes, complejidad y Arqueología: otra forma de ver el pasado
2018
La ciencia moderna se ha benefi ciado de los intentos del positivismo y neopositivismo por explicar el mundo sensible, que han generando grandes avances en el mundo de la ciencia, pero que han tenido problemas a la hora de plantear una “Teoría del Todo”. Hay que destacar el hecho de que toda explicación de la realidad es siempre un modelo simplifi cado, que se basa en alguna teoría. Durante los años 90, con el fi n de avanzar en la comprensión de la realidad empírica, comenzaron su andadura lo que se conoce co mo Ciencias de la Complejidad. A través de ellas se pretende explicar una serie de fenómenos comúnes a todos los sistemas formados por elementos interrelacionados, que como un conjunt…
Experimental evaluation of topological-based fitness functions to detect complexes in PPI networks
2012
The detection of groups of proteins sharing common biological features is an important research issue, intensively investigated in the last few years, because of the insights it can give in understanding cell behavior. In this paper we present an extensive experimental evaluation campaign aiming at exploring the capability of Genetic Algorithms (GAs) to find clusters in protein-protein interaction networks, when different topological-based fitness functions are employed. A complete experimentation on the yeast protein-protein interaction network, along with a comparative evaluation of the effectiveness in detecting true complexes on the yeast and human networks, reveals GAs as a feasible an…
Multi-functional Protein Clustering in PPI Networks
2008
Protein-Protein Interaction (PPI) networks contain valuable information for the isolation of groups of proteins that participate in the same biological function. Many proteins play different roles in the cell by taking part in several processes, but isolating the different processes in which a protein is involved is often a difficult task. In this paper we present a method based on a greedy local search technique to detect functional modules in PPI graphs. The approach is conceived as a generalization of the algorithm PINCoC to generate overlapping clusters of the interaction graph in input. Due to this peculiarity, multi-facets proteins are allowed to belong to different groups correspondi…
Correcting for the study bias associated with protein-protein interaction measurements reveals differences between protein degree distributions from …
2015
Protein–protein interaction (PPI) networks are associated with multiple types of biases partly rooted in technical limitations of the experimental techniques. Another source of bias are the different frequencies with which proteins have been studied for interaction partners. It is generally believed that proteins with a large number of interaction partners tend to be essential, evolutionarily conserved, and involved in disease. It has been repeatedly reported that proteins driving tumor formation have a higher number of PPI partners. However, it has been noticed before that the degree distribution of PPI networks is biased toward disease proteins, which tend to have been studied more often …
Structural and Gelation Characteristics of Metallo-Supramolecular Polymer Model-Network Hydrogels Probed by Static and Dynamic Light Scattering
2021
Supramolecular polymer gels are a promising class of materials whose polymer components are connected by transient bonds such as metal–ligand interactions, thereby spanning a dynamic network throug...
Analysis of network rumor dissemination and control mechanisms on Chinese social network : Sina Weibo
2016
The social network has become a major source of information. The openness and swiftness of the network bring instant accessing to both true and false information. Sometimes the false information such as network rumors can mislead people from obtaining the true information and even create chaos. The social network platforms and the governments in different countries are making effort on enacting their own mechanisms to strive on eliminating the rumors. The aim of this thesis is to investigate the spreading of rumors on the Chinese social networking website Sina Weibo. The censorship policy of the Chinese government and the methods used to control the spreading of rumors are discussed. The la…
Exploring learning analytics on YouTube: a tool to support students interactions analysis
2021
YouTube is a free online video-sharing platform that is often used by students for their learning activities. The interactions of the students when using the platform to shape new concepts, are worth to be investigated to better understand and to optimize the learning opportunities that take place in this platform. In this paper, we investigate which types of data are relevant to analyse the interactions of students with content on YouTube, and we introduce a new tool that emulates students’ interactions with the platform in order to provide data to be used in supporting Learning Analytics approaches. Our preliminary study inspects the tool effectiveness in data collection and analyses the …
Non-elected Political Elites in the EU
2017
With globalization and Europeanization, profound changes have taken place in the composition and structure of elites. Once solidly tied to the nation state, elites have, following processes of differentiation and specialization, become more transnational than ever before. Their development has been conditioned by the evolving relationship between international, transnational, and national powers. In the European context, key institutional players today include the European Commission, the European Ombudsman and the European Court of Justice as aspiring representatives of the general European interest and the Council of Ministers and member states as representing national interests in the EU…
Deconstructing and reconstructing resilience: a dynamic network approach
2019
Resilience is still often viewed as a unitary personality construct that, as a kind of anti-nosological entity, protects individuals against stress-related mental problems. However, increasing evidence indicates that the maintenance of mental health in the face of adversity results from complex and dynamic processes of adaptation to stressors that involve the activation of several separable protective factors. Such resilience factors can reside at biological, psychological and social levels and may include stable predispositions (such as genotype or personality traits) and malleable properties, skills, capacities or external circumstances (such as gene expression patterns, emotion regulatio…