Search results for "work"

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

2021

AbstractGeneration of oligodendrocytes in the adult brain enables both adaptive changes in neural circuits and regeneration of myelin sheaths destroyed by injury, disease, and normal aging. This transformation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes requires processing of distinct mRNAs at different stages of cell maturation. Although mislocalization and aggregation of the RNA binding protein TDP-43 occur in both neurons and glia in neurodegenerative diseases, the consequences of TDP-43 loss within different stages of the oligodendrocyte lineage are not well understood. By performing stage-specific genetic inactivation of Tardbp in vivo, we show that olig…

Unlock ways to share data on peer review

2020

Peer review is the defining feature of scholarly communication. In a 2018 survey of more than 11, 000 researchers, 98% said that they considered peer review important or extremely important for ensuring the quality and integrity of scholarly communication.

Main Steps in Image Processing and Quantification: The Analysis Workflow

2019

In the last decades, the variety of programs, algorithms, and strategies that researchers have at their disposal to process and analyze image files has grown extensively. However, these are only pointless tools if not applied with the careful planning required to achieve a succesful image analysis. In order to do so, the analyst must establish a meaningful and effective sequence of orderly operations that is able to (1) overcome all the problems derived from the image manipulation and (2) successfully resolve the question that was originally posed. In this chapter, the authors suggest a set of strategies and present a reflection on the main milestones that compose the image processing workf…

Betweenness Centrality for Networks with Non-Overlapping Community Structure

2018

Evaluating the centrality of nodes in complex networks is one of the major research topics being explored due to its wide range of applications. Among the various measures that have been developed over the years, Betweenness centrality is one of the most popular. Indeed, it has proved to be efficient in many real-world situations. In this paper, we propose an extension of the Betweenness centrality designed for networks with nonoverlapping community structure. It is a linear combination of the so-called “local” and “global” Betweenness measures. The Local measure takes into account the influence of a node at the community level while the global measure depends only on the interactions betwe…

2020

Hierarchy and centrality are two popular notions used to characterize the importance of entities in complex systems. Indeed, many complex systems exhibit a natural hierarchical structure, and centrality is a fundamental characteristic allowing to identify key constituents. Several measures based on various aspects of network topology have been proposed in order to quantify these concepts. While numerous studies have investigated whether centrality measures convey redundant information, how centrality and hierarchy measures are related is still an open issue. In this paper, we investigate the association between centrality and hierarchy using several correlation and similarity evaluation mea…

A comparison between nine laboratories performing triangle tests

2012

WOS: 000299451400001; International audience; Fifteen groups of participants in nine laboratories performed triangle tests with two pairs of soft drinks. Groups differed in practice level with triangle tests: eight groups of 60 consumers who were not used to triangle test, three groups of qualified assessors who have already performed a few triangle tests, and four groups of trained assessors with a more extensive practice of triangle tests; qualified and trained groups included 9 or 18 assessors. The soft drinks were made from syrups at two levels of dilution in order to achieve about 55% of correct responses to test for difference and about 40% of correct responses to test for similarity.…

The pre-Medical Emergency Team response: Nurses' decision-making escalating deterioration to treating teams using urgent review criteria.

2020

Aim To describe nurses' decision-making, experiences and perceptions of escalating deteriorating patients to the treating medical team using urgent clinical review criteria. Design A qualitative design comprising individual in-depth interviews with nurses from a major Australian metropolitan tertiary teaching hospital. Method A purposive sample of 30 Registered Nurses from nine surgical and medical wards were interviewed in April 2018 using semi-structured interviews. An inductive thematic analysis was conducted. Results Identified themes included: detecting the deterioration; countering the problem; getting a response; and challenges faced in the process of escalation. Nurses reported an i…

Associations of Trait Emotional Intelligence with Social Support, Work Engagement, and Creativity in Japanese Eldercare Nurses

2016

The psychological, psychotherapeutic and medical dimensions of the activities of social services in Poland

2018

Abstract The article is an attempt to look at the issue of functioning of social services in Poland from an interdisciplinary perspective, presenting common areas of activity of professionals with socio-pedagogical affiliation with representatives of psychological, psychotherapeutic and medical environments. The considerations relate not only to the literature of the subject, but also to the research of the authors in this regard. The purpose of the presented reflection is also to indicate the areas of interdisciplinary scientific cooperation, including research. Its effect could be generating new research problems and solving them in the course of the work of interdisciplinary teams.

A Review of the State-of-the-Art of Assistive Technology for People with ASD in the Workplace and in Everyday Life

2019

Part 8: Digital Divide and Social Inclusion; International audience; Autism, also known as autism spectrum disorder (ASD), is an incurable brain-based disorder that refers to a wide range of complex neurodevelopment disorders characterised by marked difficulties in communication and social skills, repetitive behaviour, highly focused interests and sensory sensitivity. Autism can present challenges for affected people at the work environment and in everyday life. The barrier for individuals with ASD increases further with changing environmental situations. Individuals with ASD have limited abilities to isolate their Five senses and often experience over- or under-sensitivity to sounds, touch…