Search results for "world"
showing 10 items of 1612 documents
Polatuzumab Vedotin in Relapsed and Refractory (r/r) Large B-Cell Lymphoma (LBCL): Real-World Data of the German National Compassionate Use Program (…
2020
Introduction The antibody-drug conjugate polatuzumab vedotin (Pola) has recently been approved in combination with bendamustine and rituximab (Pola-BR) for patients with r/r diffuse LBCL (DLBCL). Methods To characterize the efficacy of Pola-BR in a real-world setting, we retrospectively analyzed data from 97 patients with r/r LBCL who were treated with Pola in 24 German centers within the national CUP. Clinical baseline and follow-up (FU) data were collected by chart review and summarized descriptively. Progression-free survival (PFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox regression methods. Fisher's exact test was used to compare categorical factors between gro…
Population Pharmacokinetics of Palbociclib in aReal-World Situation
2021
Palbociclib is an oral cyclin-dependent kinase inhibitor that is used in combination with aromatase inhibitors in the treatment of postmenopausal women with metastatic breast cancer. Its metabolism profile is associated with an important interpatient variability. We performed a population pharmacokinetics study of palbociclib in women routinely followed in a cancer center. One hundred and fifty-one samples were analyzed. The sampling times after administration ranged from 0.9 to 75 h and the samples were taken between 1 and 21 days after the beginning of the palbociclib cycle. Palbociclib was determined using a validated mass spectrometry method. The best model that described the concentrat…
Synchronicity matters: defining the characteristics of digital generations
2015
This paper investigates whether or not the proposition that the second digital generation (or so-called digital natives) is more engaged in social use of the Internet than older generations is tenable. By analysing nationally representative questionnaire-based survey data collected from Finland in 2011 (N = 612), the study shows that rather than social use of the Internet in general, it is the synchronicity of online communication that distinguishes user generations. Results show that, in contrast to asynchronous modes of online communication (e.g. social networking sites, blogs and online discussion forums), synchronous modes (e.g. instant messaging and Internet calls) are clearly generati…
Semi-automatic Derivation of Specific-Domain Ontologies for the Semantic Web
2006
This paper describes an approach for helping in the semi-automatic construction of specific-domain ontology components contained in a digital archive. This proposal for extracting knowledge from digital sources allows users to have a view of this knowledge and visualize specific-domain ontology components that with further processing can be shared with software agents by embedding it into digital archives themselves in the context of the Semantic Web. In particular, we deal with the issue of not constructing the ontology from scratch, our approach helps us to speed up the ontology creation process.
Open government data portal usability: A user-centred usability analysis of 41 open government data portals
2021
Abstract Open government data, as a phenomena, may be considered an important and influential innovation that has the potential to drive the creation of public value via enabling the prevention of corruption, increase in accountability and transparency, and driving the co-creation of new and innovative services. However, in order for open government data to be fully taken advantage of, it must be found, understood, and used. Though many countries maintain open government data portals, the usability of said portals can vary greatly; this is important to understand as the usability of a portal likely impacts the eventual reuse of the data made available there. Acknowledging the importance of …
OWL Orthogonal Extension
2012
It is critical for knowledge bases to capture the reality in direct and intuitive way. OWL ontology language was designed for this goal. In this paper we study the limitations of the OWL open world semantics for the task of knowledge capture and retrieval. We propose a new mechanism based on the closed world semantics that alleviates part of the limitations. Further we describe a system where both OWL and the new mechanisms interoperate together. Finally, we outline some immediate applications and further research directions.
Sirene nell'Ade. L'aulo, la lira e il lutto
2016
Although music might seem to have nothing to do with death and the grief caused by it (to ban any music making from one’s house is a distinctive feature of mourning), yet dirges (threnoi) bestow upon the deceased both praise and the possibility to be remembered, and soothe the grief of his family and friends, and of the community as a whole. Thus the living accompany the soul of the dead in its descent to the Underworld by means of music, that seems to be the last connection with life. On a mythical-religious level, such an accompaniment is brought about by the Sirens, prayed by Helen so that they could join her in mourning the loss of the many warriors who have died because of her (Eur. He…
Dental caries experience, tooth surface distribution and associated factors in 6- and 13- year- old school children from Davangere, India
2012
Objectives: The objective of the present study was to investigate the caries experience and patterns in a sample of 6- and 13- year old school children and to estimate the contributing roles of the likely risk indicators. Study design: Data were obtained from 400 (196, 6-year old and 204, 13-year old) school children. A questionnaire was sent to the children parents to measure socioeconomic, socio-demographic, and behavioral variables. Dental caries detection was performed according to the World Health Organization criteria (dmft and DMFT). The mean dmft/DMFT scores were analysed either as a continuous (calculating means and standard deviations) or as a categorical variable (providing propo…
From World3 to the Social Assessment of Technology: Remarks on Science, Technology, and Society
1993
From a well-known point of view, science is thought to constitute a world of objective entities (World3) different from the objective world of material things (World 1) and the subjective world of minds or mental states (World2). This is an old trichotomy, of which Popper is the leading contemporary proponent.
DiDuSoNet: A P2P architecture for Ditributed Dunbar-based Social Networks,
2015
Online Social Networks (OSNs) are becoming more and more popular on the Web. Distributed Online Social Networks (DOSNs) are OSNs which do not exploit a central server for storing users data and enable users to have more control on their profile content, ensuring a higher level of privacy. In a DOSN there are some technical challenges to face. One of the most important challenges is the data availability problem when a user is offline. In this paper we propose DiDuSoNet, a novel P2P Distributed Online Social Network where users can exercise full access control on their data. Our system exploits trust relationships for providing a set of important social services, such as trustness, informati…