Search results for "world"

The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?

2022

Abstract This overview of the fifth edition of the WHO classification of thymic epithelial tumors (including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]), mediastinal germ cell tumors, and mesenchymal neoplasms aims to (1) list established and new tumor entities and subtypes and (2) focus on diagnostic, molecular, and conceptual advances since publication of the fourth edition in 2015. Diagnostic advances are best exemplified by the immunohistochemical characterization of adenocarcinomas and the recognition of genetic translocations in metaplastic thymomas, rare B2 and B3 thymomas, and hyalinizing clear cell carcinomas. Advancements at the molecular and tumor biolog…

The Autoimmune Regulator AIRE in Thymoma Biology: Autoimmunity and Beyond

2010

Thymomas are tumors of thymic epithelial cells. They associate more often than any other human tumors with various autoimmune diseases; myasthenia gravis is the commonest, occurring in 10-50% of thymoma patients, depending on the World Health Organization-defined histologic subtype. Most thymomas generate many polyclonal maturing T lymphocytes but in disorganized microenvironments Failure to induce self-tolerance may be a key factor leading to the export of potentially autoreactive CD4 progeny, thus predisposing to autoimmune diseases. Normally, the master Autoimmune Regulator promotes expression of peripheral tissue-restricted antigens such as insulin by medullary thymic epithelial cells a…

Real World Evidence data – pharmacy base survey on different patient profils characterisation and therapeutic responses for ambroxol in the OTC setti…

2018

Retrospective screening for SARS-CoV-2 among influenza-like illness hospitalizations: 2018-2019 and 2019-2020 seasons, Valencia region, Spain

2021

Este artículo se encuentra disponible en la siguiente URL: https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.12899 En este artículo de investigación también participan: Juan Mollar-Maseres, Germán Schwarz-Chavarri, Sandra García-Esteban, Joan Puig-Barberà, Javier Díez-Domingo y F. Xavier López-Labrador. On 9 March 2020, the World Health Organization (WHO) Global Influenza Programme (GIP) asked participant sites on the Global Influenza Hospital Surveillance Network (GIHSN) to contribute to data collection concerning severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We re-analysed 5833 viral RNA archived samples collected prospectively from hospital admissions for influenza-lik…

Global functorial hypergestures over general skeleta for musical performance

2016

Musical performance theory using Lagrangian formalism, inspired by physical string theory, has been described in previous research. That approach was restricted to zero-addressed hypergestures of local character, and also to digraph skeleta of simple arrow type. In this article, we extend the theory to hypergestures that are defined functorially over general topological categories as addresses, are global, and are also defined for general skeleta. We also prove several versions of the important Escher Theorem for this general setup. This extension is highly motivated by theoretical and practical musical performance requirements of which we give concrete examples.

Hypergestures in Complex Time: Creative Performance Between Symbolic and Physical Reality

2015

Musical performance and composition imply hypergestural transformation from symbolic to physical reality and vice versa. But most scores require movements at infinite physical speed that can only be performed approximately by trained musicians. To formally solve this divide between symbolic notation and physical realization, we introduce complex time (\(\mathbb {C}\)-time) in music. In this way, infinite physical speed is “absorbed” by a finite imaginary speed. Gestures thus comprise thought (in imaginary time) and physical realization (in real time) as a world-sheet motion in space-time, corresponding to ideas from physical string theory. Transformation from imaginary to real time gives us…

Quantifying the health impacts of outdoor air pollution: useful estimations for public health action

2013

According to WHO,1 health impact assessment (HIA) is A combination of procedures, methods and tools used to evaluate the potential health effects of a policy, programme or project. Using qualitative, quantitative and participatory techniques, HIA aims to produce recommendations that will help decision makers and other stakeholders make choices about alternatives and improvements to prevent disease/injury, and to actively promote health. The typical procedural steps in HIA include screening, scoping, assessment of health effects, recommending alternatives and mitigations, reporting and monitoring.2 Each step helps predict or foresee potential effects of policy decisions on a population's hea…

Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000-2018

2021

Exclusive breastfeeding (EBF)—giving infants only breast-milk for the first 6 months of life—is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (LMICs) are required for planning policy and interventions. Here we present a geospatial analysis of EBF prevalence estimates from 2000 to 2018 across 94 LMICs mapped to policy-relevant administrative units (for example, districts), quantify subnational inequalities and their changes over time, and estimate probabilities of meeting the World Health …

Real-World Evidence of Tisagenlecleucel for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

2020

Introduction Tisagenlecleucel (tisa-cel) is a second generation, CD19-targeted Chimeric Antigen Receptor (CAR) T-cell therapy for relapsed or refractory (R/R) large B-cell lymphoma (LBCL). The pivotal phase 2 trial JULIET included 93 patients and reported an overall response rate (ORR) of 52% and a complete response rate of 40% among treated patients. However, very little is known regarding its safety and efficacy in the commercial or real-world setting as well as from an intention-to-treat perspective. In our study, we report clinical outcomes of patients with R/R LBCL treated with commercial tisa-cel in 10 Spanish institutions. Methods Data were collected retrospectively from all consecut…

Dimensionality and factorial invariance of religiosity among Christians and the religiously unaffiliated: A cross-cultural analysis based on the Inte…

2019

We present a study of the dimensionality and factorial invariance of religiosity for 26 countries with a Christian heritage, based on the 1998 and 2008 rounds of the International Social Survey Programme (ISSP) Religion survey, using both exploratory and multi-group confirmatory factor analyses. The results of the exploratory factor analysis showed that three factors, common to Christian and religiously unaffiliated respondents, could be extracted from our initially selected items and suggested the testing of four different three-factor models using multi-group confirmatory factor analysis. For the model with the best fit and measurement invariance properties, we labeled the three resulting…