Search results for "wound"

Production of VEGF and b-FGF in the drainage fluid from patients undergoing incisional hernia repair

2005

Wound healing is a complex process involving interaction between different cell types, such as growth factors. Among these, vascular endothelial growth factors (VEGF) and basic fibroblast growth factors (b-FGF) are the most important. The aim of this study was to assess the production of VEGF and b-FGF in wound drainage fluid from patients undergoing incisional abdominal hernia repair. Ten female patients with abdominal midline incisional hernia undergoing surgical repair were included in this study. In all cases a closed suction drain was placed in the wound below the fascia and removed on postoperative day 4. Wound fluid was collected on the I, II, III and IV day and its amount at each ti…

Characteristics of new patient referrals to specialised diabetic foot units across Europe and factors influencing delays

2021

Objective: Foot ulcers are a common complication of diabetes and are associated with an increase in lower limb amputation and death. Early referral to a specialised unit is recommended. The aim of this study was to assess the characteristics of new-patient referrals to specialised diabetes foot care units across Europe and to determine the factors involved in delayed referral. Method: In this prospective observational study, consecutive patients with a new foot ulcer presenting to nine diabetic foot centres in five European countries (France, Germany, Italy, Spain and the UK) were included. Results: Some 25% of the 332 patients included had presented with a foot ulcer >3 months before re…

EVALUATION OF THE EFFECTS OF CONTI- NUOUS PREPERITONEAL WOUND INFILTRATION ON POSTOPERATIVE RESPIRATORY PERFORMANCE IN PATIENTS WHO UNDERWENT MAJOR A…

2013

Aim. According to the recent literature, continuous pre-perito- neal wound infiltration with local anaesthetics (CPWI) is an effective analgesic therapy in patients who undergo major abdominal surgery 1. Although it is not inferior to other com- monly used techniques in postoperative analgesia, many studies report conflictive results about its efficacy compared to them 2. The aim of our study was to evaluate the effects of CPWI on the postoperative respiratory performance in patients after major abdominal surgery. Materials and methods. From June 2011 to July 2012, a total of 14 patients have been evaluated. All patients were treated using the protocol generally used in our Department for t…

Spheroids of adipose derived stem cells show their potential in differentiating towards the angiogenic lineage

2023

Introduction: Adipose derived stem cells (ASCs) are a mesenchymal stem cell population of great scientific interest due to their abundance and easiness in obtaining them from adipose tissue. Recently, several techniques for three dimensional (3D) ASCs cultivation have been developed to obtain spheroids of adipose stem cells (SASCs). It was already proved that ASCs are able to differentiate towards the endothelial lineage thus, for the first time, we investigated the ability of our 3D SASCs to differentiate endothelially and the effects of not differentiated SASC secreted factors on specific cultured cells. Materials and methods: SASCs were differentiated with a specific medium towards endot…

How was the Turin Shroud Man crucified?

2014

As the literature is not exhaustive with reference to the way the Turin Shroud (TS) Man was crucified, and it is not easy to draw significant information from only a "photograph" of a man on a linen sheet, this study tries to add some detail on this issue based on both image processing of high resolution photos of the TS and on experimental tests on arms and legs of human cadavers. With regard to the TS Man hands, a first hypothesis states that the left hand of the TS Man was nailed twice at two different anatomical sites: the midcarpal joint medially to the pisiform between the lunate/pyramidal and capitate/uncinate bones (Destot's space) and the radiocarpal joint between the radio, lunate…

Mangiferin nanoemulsions in treatment of inflammatory disorders and skin regeneration

2018

Abstract In this paper mangiferin nanoemulsions were developed using hyaluronic acid of different molecular weight, in absence or presence of Transcutol-P. An extensive study was carried out on the physico-chemical properties of nanoemulsions. Nanosizer and transmission electron microscopy showed oil droplets average size 296 nm with monodisperses distribution (PI ≤ 0.30). The zeta potential was highly negative (−30 mV). FTIR analysis confirms the existence of physical interactions among compounds. Rheological measurements allowed to conclude that all formulations present a pseudoplastic behavior (s ∼ 0.4) in presence of the biopolymer. Moreover, mangiferin release depends on the molecular …

Xyloglucan-based hydrogels: A biomaterials chemistry contribution towards advanced wound healing

The last two decades have witnessed the introduction of several new wound dressings, with many of them being hydrogels for the advantages that these materials can offer in the application. However, despite the advancements and the wide range of dressings available, wound management is still an extremely challenging task due to its subjectivity, complexity and scarce knowledge of the wound healing process itself, and patient variability. For this reason, an interdisciplinary approach to wound care that can help reducing the incidence and prevalence of wounds is needed. One important goal would be to develop “smart” wound dressings that are easy to apply, wear and be removed, that are able to…

Volatile Organic Compounds of Malignant Breast Cancer Wounds: Identification and Odors.

2018

International audience; Introduction. During the metabolic processes of malignant wounds, bacteria produce a large amount of volatile organic compounds (VOCs) that are responsible for malodors and may have a major impact on the patient's quality of life with a risk of isolation. Objective. A translational study was conducted on 32 malignant breast wounds by combining the identification of bacterial strains present on wounds, the identification of VOCs produced by these bacterial strains, and sensory evaluation to assess odor intensity and quality of odorous bacteria. Materials and Methods. Thirty-two patients with malignant breast cancer wounds > 10 cm(2) at various stages of the disease (c…

Modelling Keloids Dynamics: A Brief Review and New Mathematical Perspectives

2022

The keloids are fibroproliferative disorders described by an excessive growth of fibrotic tissue, which also invades adjacent areas (beyond the original wound borders). Since these disorders are specific to humans (no other animal species naturally develop keloid-like tissue), the experimental in vivo/in vitro research has not lead to significant advances in this field. One possible approach could be to combine in vitro human models with calibrated in silico mathematical approaches (i.e., models and simulations) to generate new testable biological hypotheses related to biological mechanisms and improved treatments. Since these combined approaches do not really exist for keloid disorders, in…

Validation of a Portuguese version of the Groningen radiotherapy-induced xerostomia questionnaire

2022

The aim of this study was to validate and determine at pretest level the reliability of the Portuguese version of the Groningen radiotherapy-induced xerostomia questionnaire. This study employed 37 head and neck cancer patients. Each patient signed an informed consent and responded to the Portuguese version of the questionnaire in the form of an interview. This was repeated again after 2 weeks. A standard single question provided a validity check. Data were analyzed using Cronbach?s ? to test its reliability and total and interitem correlation, and intraclass correlation to determine its internal consistency and test-retest reliability. Construct validity supported by objective measurements…