Search results for "wound"

Does prehospital care by physicians result in a better outcome than resuscitation by other EMS personnel?

1993

The European trauma course – trauma teaching goes European

2014

The World Health Organization (WHO) has identified trauma as the major health care challenge of our century, claiming more productive life years worldwide than any other disease [1]. In the European Union (EU), injury accounts for 15 % of all deaths before the age of 60 years and is the fourth most common cause of death, with more than 235,000 deaths each year from injuries, equating to 600 injury fatalities per day [2]. In children, adolescents and young adults, accident and injury rates are even higher, being the leading cause of death in these age groups. Mortality from trauma in the EU has fallen 20 % in the past 20 years, to a rate of 63.7 per 100,000 in 2010 [3]. This reduction is par…

Histological effects of He-Ne laser on the healing of experimental colon anastomoses in the rat

1990

Despite technical advances, the incidence of anastomotic leaks in elective colorectal surgery remains around 14%, Recent studies suggest that the use of low energy lasers may enhance wound healing in different tissues in a selective, nondestructive manner. Based on these findings we have attempted to provide experimental background on the histological effects of He-Ne laser during the early stages of healing in 70 colonic anastornoses performed on rats, The irradiation of the anastomoses by two doses of 3.6 J/cm produces an increase in the populations of round cells and fibroblasts of the scar tissue, an increase in new vessel formation and a significant improvement in epithelialization. Th…

Propeller flap for treatment of a poststernotomy sternal fistula: A case report.

2014

Summary The treatment of post-operative deep sternal wound infections is a real challenge for surgeons. Conservative treatment with debridement and vacuum-assisted closure (VAC) therapy is not always successful. In the most severe and chronic cases, a surgical debridement and reconstruction of the defect is mandatory. In this report, the authors present a case of a 61-year-old female patient with a chronic cutaneous fistula in the sternal region following a median sternotomy after coronary artery bypass. The patient had already undergone treatment with antibiotics, drainage of an abscess and local debridement, but the infection continued to relapse periodically. The authors decided to treat…

A Direct Comparison of Seprafilm, Adept, Intercoat, and Spraygel for Adhesion Prophylaxis

2010

Background Commercially available agents for adhesion prophylaxis are legion but there is a lack of direct comparisons between them. Here we compare four of the most commonly used adhesion barriers against a control group in a clinically relevant rat model. Material and Methods Standardized lesions were created in Wistar rats using electrocautery and suturing. Subsequently, the experimental lesions were treated with Seprafilm (n = 30), Adept (n = 30), Intercoat (n = 30), Spraygel (n = 30), or no barrier (n = 30). The resulting adhesions were examined 14 d postoperatively. Results The mean area covered by adhesion was 77% in the control group, 46% in animals treated with Seprafilm, 54% in an…

The influence of the C1-inhibitor BERINERT® and the protein-free haemodialysate ACTIHAEMYL20%® on the evolution of the depth of scald burns in a porc…

1997

Standardized deep partial-thickness burns were inflicted on domestic pigs by scalding 30 per cent of the skin surface for 25 s with 75 degrees C hot water. The animals (n = 18; weight 25-35 kg) were divided into three groups: I, control group (n = 6), Ringer's lactate only; II, haemodialysate group (n = 6), Ringer's lactate and a protein-free haemodialysate of calf-blood (ACTIHAEMYL20%; AH) and III, C1-inhibitor group (n = 6), Ringer's lactate and C1-inhibitor (C1-INH; BERINERT). Skin biopsies were taken at defined time points (4, 28, 52 and 76 h) and investigated histologically. Depth of burn was determined morphometrically after coloration with a modified MTT-staining on frozen sections o…

La guarigione della ferita chirurgica nel cavo orale

2021

OBJECTIVES The aim of the study is to describe the physiological mechanism of healing of the surgical wound of the oral cavity and to present the systemic and local factors that can influence it. MATERIALS AND METHODS Hemostasis starts with the activation of the platelets and the coagulation cascade which carry out the vascular constriction and the formation of the fibrin clot which stops the blood loss and provides a temporary scaffold for the migration and anchoring of the cells that will reach the subsequent stages. The clot and surrounding injured tissue begin to release pro-inflammatory cytokines and growth factors such as tranforming growth factor-β (TGF-β), platelet-derived growth fa…

Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding

2001

Recently, we have discovered that neuropeptide Y (NPY), a sympathetic neurotransmitter, is also present in human umbilical endothelial cells (HUVECs), and is potently chemotactic and angiogenic by acting on one or several of Y1-Y5 receptors. In HUVECs, NPY is co-localized with dipeptidyl peptidase IV (DPPIV) which cleaves Tyr(1)-Pro(2) from NPY(1-36) to form NPY(3-36) resulting in the formation of a non-Y1 receptor agonist, which remains angiogenic. Presently we studied the effects of DPPIV's blockade using monoclonal antibodies (mAbs) on migration of HUVECs in response to NPY(1-36) or NPY(3-36) following cell wounding. Both peptides caused similar dose-dependent increases in cell migration…

Are we really seeing the total costs of surgical site infections? A Spanish study.

2007

To identify overall costs generated by surgical site infections (SSI) patients, including indirect costs. A prospective study of case series of patients who have undergone major surgical treatment was undertaken. Patients who suffered SSI were compared with controls (nested case-control design). Centers for Disease Control and Prevention definitions were followed and SSI established. Overall costs and indirect related morbidity/mortality costs were estimated. The study was performed in a general, tertiary hospital (Valencia, Spain) for 4.5 years. Surgical site infections patients were 9.02% of the total people who underwent surgery. Their stays were prolonging by 14 days, and resources were…

Long-Term Results of Buccal Mucosa Onlay Grafts in Hypospadias Repair

2010

Purpose Buccal mucosa onlay grafts are widely used in complex Hypospadias surgery. In a retrospective study we evaluated the long-term results in patients with a minimum follow-up of 5 years. Material and Methods All patients in who underwent buccal mucosa grafting for Hypospadias repair in our institution received a questionnaire and were invited for a follow-up visit. The questionnaire included two visual analogue scales (VAS) concerning the functional and cosmetic result (0 = very dissatisfied; 50 = satisfied; 100 = very satisfied). Results A total of 85 patients with a median age at the operation of 7.4 years (1 – 60 years) could be followed for a median of 8 years (5-16 years). In 36/8…