Search results for "wt"
showing 10 items of 5424 documents
Beyond GDP: an analysis of the socio-economic diversity of European regions
2019
International audience; This paper aims to analyze the socioeconomic diversity of the European Union (EU-28) regions from a dynamic perspective. For that purpose, we combine a series of exploratory space-time analysis approaches to multiple Factor Analysis (MFA) applied to a large range of indicators collected at the NUTS-2 level for the period 2000–2015 for the EU-28. First, we find that the first factor of MFA, interpreted as economic development (ECO-DEV), is spatially clustered and that a moderate convergence process is at work between European regions from 2000 to 2015. Second, when comparing these results with those obtained for Gross Domestic Product (GDP) per capita, we show that th…
Oxygenation Status of Rhabdomyosarcoma Spheroids with Different Stages of Differentiation
1994
Multicellular tumor spheroids with regional heterogeneities of proliferation and substrate concentrations have been investigated recently to study the biological properties of small tumor nodules prior to onset of vascularization (for reviews see: Mueller-Klieser, 1987; Sutherland, 1988).
Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)
2016
Background & Aims: A novel family of proton-sensing G-proteinâcoupled receptors, including ovarian cancer G-proteinâcoupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a result of anaerobic glucose metabolism through the stabilization of hypoxia-inducible factor-1α. We investigated how hypoxia regulates the expression of OGR1 in the intestinal mucosa and associated cells. Methods: OGR1 expression in murine tumors, human colonic tissue, and myeloid cells was determined by quantitative reverse-transcription polymerase chain reaction. The influence of hypoxia on OGR1 expression was studied in monocytes/macrophages and…
Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase
2015
Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …
Mosaic activating mutations in GNA11 and GNAQ are associated with phakomatosis pigmentovascularis and extensive dermal melanocytosis
2016
Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were det…
Motivisk symbolikk i Bach's tonespråk
2006
Masteroppgave i utøvende musikk 2006 - Høgskolen i Agder, Kristiansand Motivisk symbolikk i Bach’s tonespråk er emnet for min mastergradsoppgave. Emnet sorterer under fordypningsområdet Interpretasjonsstudier i mastergradsstudiet i utøvende musikk, ved Høgskolen i Agder, 2006. Oppgaven består av 81 sider og inneholder bl.a. noteeksempler og en CD innspilling av to preludier og to fuger av J.S. Bach. Målet med å skrive oppgaven har vært å vise at det finnes et religiøst innhold i Bach’s instrumental-komposisjoner, som vanligvis betraktes som ”abstrakt” musikk. Den skriftlige delen består av tre deler: I den første delen har jeg drøftet et religiøst innhold i forskjellige kunstretninger i bar…
EC Practice in the WTO: How Wide is the "Scope for Manouvre"?
2004
The EC’s implementation record in the WTO seems to reflect an attitude that, in accordance with the view traditionally maintained by the European Court of Justice from International Fruit to Portugal, finds its cornerstone in the principle of negotiations with a view to achieving mutually satisfactory solutions, even beyond the limits set by the DSU. Following these premises, the purpose of this paper is to analyse the impact that has been exercised on the EC’s contentious practice by interpretations of the WTO system given by the EC courts, in fine tuning with the stand taken by the EC’s political bodies. After having considered the legal and political reasons behind the case-law of the Co…
Effects of the Blair/Brown NHS Reforms on Socioeconomic Equity in Health Care
2012
The central objectives of the ‘Blair/Brown’ reforms of the English NHS in the 2000s were to reduce hospital waiting times and improve the quality of care. However, critics raised concerns that the choice and competition elements of reform might undermine socioeconomic equity in health care. By contrast, the architects of reform predicted that accelerated growth in NHS spending combined with increased patient choice of hospital would enhance equity for poorer patients. This paper draws together and discusses the findings of three large-scale national studies designed to shed empirical light on this issue. Study one developed methods for monitoring change in neighbourhood level socioeconomic…
Health and the war. Changing schemes and health conditions during the Spanish civil war
2008
This paper focuses on the health reforms during the republican Spain (1931-1939) and the crisis derived from the three-year of civil war. It considers how the war affected the health system and the impairment of health conditions of the population during the late 1930s, considering the changing conditions caused by the conflict. Some of the specific topics analysed are the changing healthcare system, the adaptation of health organization after the outbreak of the war, the impact of the war on the health of the population and epidemiological changes, the problem of the refugees and the clinical studies by experts, mainly on undernourishment.
Hsp60 in embryonic and adult submandibular salivary gland: quantitative distribution patterns in normal tissue and comparison with benign and maligna…
2019
Introduction: Heat Shock Protein 60 (Hsp60) is a member of the chaperoning system that assists protein folding inside mitochondria and plays other roles beyond these organelles. It is implicated in the carcinogenic processes in various types of cancer. In human salivary glands, Hsp60 has not yet been measured or mapped in detail and its role in gland development and functioning is virtually unknown. Consequently, its potential as biomarker for gland diseases, including malignancies cannot be assessed. The S-100 protein, a known marker for schwannomas, has been found also in myoepithelial-cell carcinomas of the salivary glands. Here, we present our initial findings on the anatomic-histologic…