Search results for "wt"
showing 10 items of 5424 documents
Appropriate management of growth hormone deficiency during the age of transition: an Italian Delphi consensus statement
2022
Growth hormone deficiency (GHD) describes the impairment of growth hormone (GH) secretion by the pituitary somatotroph cells. GHD may be congenital, with causes, including genetic alterations and structural brain malformations, or acquired, including midline tumours, cranial irradiation, traumatic brain injury, central nervous system infections and inflammatory conditions. GHD in children is characterised by short stature, delayed bone maturation and abnormalities in substrate metabolism, body composition, physical and psychosocial functioning, all of which improve with recombinant human GH (rhGH) therapy. The diagnosis of GHD is based on clinical signs and symptoms, biochemistry and imagin…
Revaluation of the clinical and metabolic behavior of GHD children during GH treatment according to newly proposed note 39 of the Italian Medicines A…
2015
Background The newly proposed note 39 of the Italian Medicines Agency (AIFA) revisited the diagnostic criteria of growth hormone deficiency (GHD) in children and, applying it, a percentage of children previously diagnosed as GHD may have received a wrong diagnosis and a unnecessary treatment, with potential clinical implications. Aim To evaluate the clinical and metabolic behavior of GH-treated children according to the new criteria of GHD diagnosis. Subjects and Methods: We retrospectively analyzed clinical and metabolic data of 310 prepubertal children (220 M, 90 F, age 10.8 ± 2.9 yrs) with short stature admitted to our section of Endocrinology during the years 2005-2014, having at least …
Lipoprotein alterations and reduced growth hormone secretion: relationships with obesity and cardiovascular risk
2012
Clinical and metabolic impact of three-times-weekly versus daily growth hormone (GH) treatment in naïve GH-deficient children
2017
OBJECTIVE: Growth hormone treatment (GHT) is commonly administered daily, although pulsatile GH secretion is unlikely to be achieved. The auxological effect of a three-injections-per-week (TIW) regimen is controversial, while the metabolic effects have been never evaluated in children. The objective was to evaluate whether two different regimens of weekly injections could lead to similar auxological and metabolic effects in children with GH deficiency (GHD). DESIGN: 32 GHD children (25 males, mean age 10.5 ± 2.2 yr) were randomly assigned to receive daily (group A, No 16) or TIW (group B, No 16) GHT for 12 months. METHODS: Auxological parameters, insulin-like growth factor-I (IGF-I), glucos…
Citronellal and citronellol as growth inhibitors of freshwater cyanobacteria
2014
Cyanobacteria possess a very high tolerance relative to environmental factors, so they can be found in almost every aquatic habitat: oceans, freshwaters, hot springs, soils and bare rocks. Nowadays these microorganisms are thought to cause the formation of intensive blooms which result from water eutrophication. In order to suppress blooms in aquatic ecosystems, it is important to limit the growth of blue-green algae, preferably using environment-friendly procedures. In this article we present how two aliphatic, natural monoterpenes: citronellal and citronellol, influence the growth of cyanobacteria. Three species of freshwater cyanobacteria: Anabaena sp., Nodularia moravica and Chroococcus…
Behind the curtain of international diversification: An agency theory perspective
2018
This paper dissects the antecedents of international diversification through the lens of the agency cost of free cash flow arguments. It explores whether the partial convergence of interests among managers, majority shareholders, and minority shareholders affects a firm's choice to diversify internationally. Using a sample panel of 60 Italian firms evaluated longitudinally from 2004 to 2014, the study tests whether a firm's international diversification is affected by its free cash flow (as the ultimate source of managerial discretion) and debt (as the main constraint to managerial discretion), especially in firm contexts that exacerbate agency problems. We find that the effects on internat…
Exogenous Growth Regulators and Water Stress Enhance Long-Term Storage Quality Characteristics of Onion
2023
Exogenous growth regulators (GRs) play a crucial role in alleviating water stress and sustaining crop yields in water-stressed areas. However, their effects on onions post-harvest quality, particularly post-monsoon onion—often preferred for long-term storage—were never studied. Therefore, this led us to investigate the interaction between water stress and GRs on the physiochemical and functional quality attributes of onions during long-term storage (9 months, at 25 ± 1 °C and 65 ± 5% RH). Onion crop was raised under four water stress levels i.e., 1.00–0.85, 0.84–0.70, 0.69–0.40, and 0.39–0.10 IW: CPE, designated as no, low, medium, and s…
Increasing the effectiveness of aggregates for planting sugar beet stecklings to receive elite seeds
2019
Article Planting sugar beet stecklings with planting machine is one of the stages in the technological process of producing elite seeds. The analysis of the experience of using planting units for planting stecklings showed a number of disadvantages: poor quality of planting stecklings without spacing stability and the absence of parameter control; unregulated applying nutrients and granules of water preservation to the roots negatively affect the development of plants. The aggregate having openers of the planting device was designed, and the system of supplying the spray of nutrients and growth stimulator is envisaged. The technological process is conducted in the following way: during the …
Chemical Composition of the Essential Oil of the New Cultivars of Lavandula angustifolia Mill. Bred in Ukraine
2021
Lavender, otherwise known as Lavandula angustifolia Mill., is widely used in landscaping, and its oil is a valuable raw material used in many industries. Therefore, new varieties of this plant are bred. The essential oil composition obtained from fresh flowers of thirteen new Ukrainian cultivars of L. angustifolia were analysed by GC-MS, and eighty-two components were identified. Linalool and linalyl acetate were principal constituents of all of the samples, and ranged from 11.4% to 46.7% and 7.4% to 44.2%, respectively. None of the studied samples fulfilled the requirements of Ph. Eur. and ISO 3515:2002. The main reason was a high content of α-terpineol (0.5–4.5%) and/or terpinene-4-ol (1.…