Search results for "wt"
showing 10 items of 5424 documents
Bone, fat and muscle gain in pubertal girls : effects of physical activity
2010
Public Libraries – Facilitators of Information Society and e- Inclusion in Latvia
2014
Abstract The economic growth and national competitiveness is closely correlated with the development of information society. In the last few years the role of public libraries has significantly increased and libraries have greatly contributed to the improvement of information society in Latvia. The usage of library services had never been as high as they were in 2011 – 42% of the population were active library users and 90% of them used the Internet. Nowadays, the public library network in Latvia provides a powerful network of information, knowledge and community centres and they are highly demanded by society.
Non-crossing quantile regression via monotone B-spline varying coefficients
2019
Quantile regression can be used to obtain a nonparametric estimate of a conditional quantile function. The presence of quantile crossing, however, leads to an invalid distribution of the response and makes it dicult to use the tted model for prediction. In this work, we show that crossing can be alleviated or completely eliminated by explicit modeling of the regression coecients as a function of the percentile values in (0,1). We illustrate the approach via a wellknown dataset by emphasizing dierences with respect to the competitors.
The reactivity of neonatal rabbits to the mammary pheromone as a probe for viability
2012
International audience; Newborn rabbits depend on a daily nursing interaction with the mother to gain milk and to survive. During this interaction, they localise and seize the nipples displaying a typical behaviour triggered by maternal odour cues. The mammary pheromone constitutes such a signal in domestic rabbits: it elicits sucking-related movements in more than 90% of the pups. However, some newborns remain unresponsive to the presentation of the pheromone, even pups apparently healthy and highly motivated to suck. The main goal of the present study was therefore to explore the link between the unresponsiveness of rabbit pups to the mammary pheromone and their growth and survival in bre…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
2010
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…
Raakaöljymarkkinoiden rakennemuutokset ja futuurimarkkinoiden tehokkuus
2017
Tutkimuksessa tutkittiin raakaöljymarkkinoiden rakennemuutoksia ja futuurimarkkinoiden tehokkuutta ja pyrittiin selvittämään, ovatko raakaöljyn futuurimarkkinat tehokkaat, onko raakaöljymarkkinoilla havaittavia rakennemuutoksia ja onko raakaöljymarkkinoiden rakennemuutoksilla vaikutusta futuurimarkkinoiden tehokkuuteen. Aineistona käytettiin Brent- ja WTI-raakaöljylaatujen spot- ja futuurihintasarjoja ajanjaksolta 24.6.1988 – 19.1.2017. Rakennemuutosta tutkittiin Zivot-Andrews –testillä ja futuurimarkkinoiden tehokkuutta lineaarisella regressiolla sekä GJR-tyyppisellä epäsymmetrisyysmuuttujalla täydennetyllä GARCH-in-Mean –mallilla. Havaitut rakennemuutokset ajoittuivat WTI:n spot- ja futuu…
Trait-specific tracking and determinants of body composition: a 7-year follow-up study of pubertal growth in girls
2009
BACKGROUND: Understanding how bone (BM), lean (LM) and fat mass (FM) develop through childhood, puberty and adolescence is vital since it holds key information regarding current and future health. Our study aimed to determine how BM, LM and FM track from prepuberty to early adulthood in girls and what factors are associated with intra- and inter-individual variation in these three tissues. METHODS: The study was a 7-year longitudinal cohort study. BM, LM and FM measured using dual-energy X-ray absorptiometry, self-reported dietary information, leisure time physical activity (LTPA) and other factors were assessed one to eight times in 396 girls aged 10 to 13 years (baseline), and in 255 moth…
Growth-associated variation in body size, hormonal status, physical performance characteristics and perceptual-motor skills in Finnish young soccer p…
2013
The territorial dimension in the EU programming and the New Framework for Public Policies: Territorial Tural Development, CAP Reform and new LEADER
2012
Lo que venimos denominando como perspectiva territorial del desarrollo es un fenómeno bastante reciente en el contexto de la Unión Europea, de apenas dos décadas. En esencia esta perspectiva territorial del desarrollo se ha centrado en un enfoque local de los procesos de desarrollo en las áreas rurales, de la mano, principalmente, de instrumentos como LEADER. La necesidad de incorporar la dimensión territorial a los procesos de desarrollo proviene no solo del éxito global de estos instrumentos, sino también por el convencimiento de que puede constituir un elemento fundamental de cara a la cohesión económica y social en el seno de la UE. Avances recientes, como el Libro Verde de la Cohesión …