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showing 10 items of 16837 documents
Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk
2010
A strong link exists between low aerobic exercise capacity and complex metabolic diseases. To probe this linkage, we utilized rat models of low and high intrinsic aerobic endurance running capacity that differ also in the risk for metabolic syndrome. We investigated in skeletal muscle gene-phenotype relationships that connect aerobic endurance capacity with metabolic disease risk factors. The study compared 12 high capacity runners (HCRs) and 12 low capacity runners (LCRs) from generation 18 of selection that differed by 615% for maximal treadmill endurance running capacity. On average, LCRs were heavier and had increased blood glucose, insulin, and triglycerides compared with HCRs. HCRs we…
Interhemispheric inhibition during mental actions of different complexity.
2013
International audience; Several investigations suggest that actual and mental actions trigger similar neural substrates. Yet, neurophysiological evidences on the nature of interhemispheric interactions during mental movements are still meagre. Here, we asked whether the content of mental images, investigated by task complexity, is finely represented in the inhibitory interactions between the two primary motor cortices (M1s). Subjects' left M1 was stimulated by means of transcranial magnetic stimulation (TMS) while they were performing actual or mental movements of increasing complexity with their right hand and exerting a maximum isometric force with their left thumb and index. Thus, we sim…
Immunoglobulin E (IgE) and ischemic heart disease. Which came first, the chicken or the egg?
2014
Several lines of evidence demonstrate that the immune system plays a pivotal role in development and progression of ischemic heart disease (IHD). More recently, a series of biological and clinical investigations has generated new interest about the existence of a relationship between a specific class of immunoglobulin, that is immunoglobulin E (IgE), and IHD. Data obtained in several epidemiological studies have convincingly demonstrated that the concentration of total serum IgEs is significantly increased in patients with IHD and often correlates with the prognosis. The putative mechanisms are essentially mediated by a physiological interaction between IgEs and mast cells, which triggers t…
Optimized culture conditions for tissue explants of uterine leiomyoma
2012
Background Uterine leiomyomas are the most common benign tumours in women, which arise from smooth muscle cells of the uterine myometrium and usually are multicentric. In spite of their frequency pathogenesis is widely unknown, mainly due to the absence of a suitable model system. We describe the systematic optimization of culturing leiomyoma tissue explants in an economical and effective ex vivo system. Methods Different concentrations of oxygen, different media, sera, hormones, and growth factor supplements were tested. Immunohistochemical stainings with antibodies against hormone receptors as well as specifying proliferation and apoptotic indices and real-time PCR were performed. Results…
Cytokine expression profile in idiopathic inflammatory myopathies.
1996
Cytokines have been shown to be potent inducers of major histocompatibility complexes (MHC) class I and II as well as of cell adhesion molecules in muscle tissue cultures, indicating that cytokines may play a role in mediating muscle fiber damage in inflammatory myopathies. We found in 21 cases of autoimmune myositis various amounts of inflammatory cells expressing interleukin (IL)-1 alpha and -beta, IL-2, IL-4, tumor necrosis factor (TNF) -alpha and -beta, and interferon (IFN)-gamma and its receptor. Muscle fibers displayed enhanced expression of IL-1 alpha and -beta, IL-2, and TNF-alpha. Upregulation of cytokines was strongest at sites of cellular infiltration typical for the respective m…
Correction: One-pot synthesis of a new generation of hybrid bisphosphonate polyoxometalate gold nanoparticles as antibiofilm agents
2019
A reduced polyoxovanadate functionalized with bisphosphonate molecules was synthesized and used to prepare in one step hybrid organic–inorganic polyoxometalate decorated gold nanoparticles. These new composites were shown to strongly inhibit P. aeruginosa and S. epidermidis biofilm growth, with the three components constituting the nanoparticles (Au0 core, vanadium and alendronate) acting synergistically.
The Effect of 16-Minute Thermal Stress and 2-Minute Cold Water Immersion on the Physiological Parameters of Young Sedentary Men
2020
This study aimed to determine the effect of 16 minutes of thermal stress followed by 2 minutes of cold water immersion on the physiological parameters of fifty-five sedentary men (mean age 20.15±1.30 years), who were exposed to 16 minutes of sauna (temperature: 90-91℃; relative humidity: 14-16%) followed by 2 minutes of cold water immersion (12℃). The participants' somatic characteristics were determined before entering the sauna, and their body mass and blood pressure were measured before and after sauna treatment. Physiological parameters were monitored during the 16-minute sauna session and the 2-minute cold water immersion (CRIO) or shower. The subjects perspired 0.21-0.27 litres during…
Komunikācijas analīze platformas “YouTube” kanāliem “PewDiePie” un “Pyrocynical”
2020
Bakalaura darbs “Komunikācijas analīze platformas “YouTube” kanāliem “PewDiePie” un “Pyrocynical”” sastāv no teorētiskās, metodoloģiskās un empīriskās daļas. Bakalaura darba teorijas daļā tika izpētīti mūsdienu mediji, to saturs, jēga, funkcijas, ietekme uz auditoriju, platforma “YouTube”, tā attīstība un mijiedarbība ar citām platformām, apskatīts influencera termins, uzzināts, kā influenceri rada diskusiju tiešaistes vidē un kā viņi ietekmē auditoriju. Bakalaura darba empīriskajā daļā tika veikta konentanalīze, kur tika apskatīts “YouTube” kanālu “PewDiePie” un “Pyrocynical” videoklipu augšupielādes biežums un videoklipa skatījumi, komentāri utt, semiotiskā analīze, kur tika analizēti šo …
Mediju lietojuma paradumi un motivācija pusaudžu auditorijā Rīgas vidusskolās
2018
Bakalaura darba “Mediju lietojuma paradumi un motivācija pusaudžu auditorijā Rīgas vidusskolās” pētījuma mērķis ir noskaidrot un atspoguļot jauniešu, vecumā no 16 līdz 19 gadiem, mediju lietojumu, motivācijas iezīmes, salīdzinot jauno un tradicionālo mediju attīstību no respondentu patēriņu paradumu aspekta. Darbs balstīts uz četrām galvenajām nodaļām – teorētisko, metodoloģisko, empīrisko un secinājumu. Teorētiskā bāze tiek koncentrēta uz mediju vides un jauniešu auditorijas raksturojumu, kas izgūts no pēdējā laikā publicētās literatūras izkonspektētā, kā arī vairāku pētījumu apkopojumiem. Tāpat darbā tiek koplietoti zinātnieku, universitātes profesoru un mediju ekspertu pieņēmumi saistībā…
Rumor de pañuelo blanco: historia, memoria y representaciones literarias de Abuelas de Plaza de Mayo
2018
El 24 de marzo de 2016 se cumplieron 40 años del golpe de Estado del autodenominado Proceso de Reorganización Nacional que condujo a siete años de una sangrienta dictadura en Argentina. De entre las organizaciones de Derechos Humanos que surgieron como respuesta a las desapariciones ilegales de militantes y de civiles, las Madres y Abuelas de Plaza de Mayo se han constituido, tanto a nivel nacional como internacional, en evidencia de la historia de violencia y en símbolo de paz; como tales también han entrado en el plano de la ficción. Teniendo en cuenta estas líneas, en el presente trabajo se realiza, primero, un recorrido por la historia de las Abuelas de Plaza de Mayo y el cambio polític…