Search results for "β-defensin"

showing 3 items of 3 documents

Association study between beta-defensin gene polymorphisms and mastitis resistance in Valle del Belice dairy sheep breed

2016

Abstract Mastitis is generally caused by bacteria, and it is the most common disease in livestock species. Defensins are peptides with a broad spectrum of antimicrobial activity and β-defensin genes have been studied in several livestock species due to their important role in the innate immune response. The aim of this study was to establish an association between polymorphisms in the β-defensin 1 and 2 genes and mastitis resistance in the Valle del Belice dairy sheep. Data consisted of 1855 and 2804 observations for case and control group, respectively. Six single nucleotide polymorphisms and seven haplotypes were selected for association studies with mastitis. In particular, polymorphism …

0301 basic medicineCandidate geneMastitis resistanceSingle-nucleotide polymorphismBiologyβ-defensin genes; Mastitis resistance; Single Nucleotide Polymorphisms; Valle del Belice dairy sheep breed03 medical and health sciencessingle nucleotide polymorphismsSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoFood AnimalsPolymorphism (computer science)β-Defensin genes mastitis resistance single nucleotide polymorphisms Valle del Belice dairy sheep breedmedicineDefensinGenetic associationGeneticsValle del Belice dairy sheep breedHaplotypemedicine.diseaseBreedMastitis030104 developmental biologySingle Nucleotide PolymorphismAnimal Science and Zoologyβ-defensin geneβ-Defensin genes
researchProduct

Study of β-defensin polymorphisms in Valle del Belice dairy sheep

2009

The aim of this work was to sequence the exons of β-defensin 1 and 2 genes (SBD1 and SBD2) in Valle del Belice dairy sheep in order to identify polymorphisms. The study was conducted on 60 samples from three flocks. Six SNPs were identified: two in SBD1 and four in SBD2. Both genes consist of two exons and one intron. In SBD1 gene, SNPs were found only in the exon 2, whereas in SBD2, SNPs were detected in both exons. In both genes, SNPs were located in the coding regions and in the 3'-UTR. The SNP in SBD2 located at position 1659 determined a change in the protein sequence. Further studies will be necessary to investigate if the amino acid change modifies the biological function of the…

GeneticsUntranslated regionsheep040301 veterinary sciences0402 animal and dairy scienceIntronβ-defensin SNP Sheep.SNPSingle-nucleotide polymorphism04 agricultural and veterinary sciencesBiology040201 dairy & animal scienceMolecular biologyβ-defensinβ-defensin; SNP; sheep0403 veterinary scienceExonSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoSNPCoding regionAnimal Science and Zoologylcsh:Animal cultureDefensinGenelcsh:SF1-1100
researchProduct

Polymorphisms at β-defensin genes and mastitis in Valle del Belice dairy sheep: a case control study

2015

Mastitis is the most common and costly pathology affecting dairy animals. The identification of genetic markers that allow the inclusion of mastitis resistance in selection programs would help to reduce the costs due to the disease and the use of antibiotics. In recent years, β-defensin genes have been studied in several domestic species due to their important role in the innate immune response. The aim of this study was to determine whether β-defensin genes variability, β-defensin 1 (SBD1) and β-defensin 2 (SBD2), could distinguish between infected cases and healthy controls in Valle del Belice dairy sheep. Somatic cell count (SCC) is a powerful tool to identify animals with intramammary i…

β-defensin genes mastitis Valle del Belice dairy sheep breedSettore AGR/17 - Zootecnica Generale E Miglioramento Genetico
researchProduct